Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice

Neuroprotective Effect of Osthole on Neuron Synapses in an Alzheimer’s Disease Cell Model via Upregulation of MicroRNA-9

(2016) Shaoheng Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms

(2016) Ying Du et al.   NEUROPHARMACOLOGY

Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer’s disease

(2016) Yanan Jiao et al.   NEUROPHARMACOLOGY

Hippocampal neurogenesis in the APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease

(2016) Q. Zeng et al.   NEUROSCIENCE

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

Osthole Upregulates BDNF to Enhance Adult Hippocampal Neurogenesis in APP/PS1 Transgenic Mice

(2015) Hong Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Coumarin Derivative Osthole Stimulates Adult Neural Stem Cells, Promotes Neurogenesis in the Hippocampus, and Ameliorates Cognitive Impairment in APP/PS1 Transgenic Mice

(2015) Liang Kong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Neuronal Differentiation by Enhancing the Wnt Signaling Pathway in an Alzheimer's Disease Model

(2015) Se Hee Oh et al.   CELL TRANSPLANTATION

Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury

(2015) Yang Xia et al.   Journal of Neuroinflammation

Reduction of inflammatory responses by l-serine treatment leads to neuroprotection in mice after traumatic brain injury

(2015) Pei-Pei Zhai et al.   NEUROPHARMACOLOGY

Transplantation of NSC-derived cholinergic neuron-like cells improves cognitive function in APP/PS1 transgenic mice

(2015) G. Gu et al.   NEUROSCIENCE

Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model

(2015) Yingjia Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Expression of Amyloid-Associated miRNAs in Both the Forebrain Cortex and Hippocampus of Middle-Aged Rat

(2014) Hui Che et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Osthole Augments Therapeutic Efficiency of Neural Stem Cells–Based Therapy in Experimental Autoimmune Encephalomyelitis

(2014) Zhong Gao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

microRNA-9 attenuates amyloidβ-induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2

(2014) FEI CHANG et al.   Molecular Medicine Reports

Neural Stem Cell Transplants Improve Cognitive Function Without Altering Amyloid Pathology in an APP/PS1 Double Transgenic Model of Alzheimer’s Disease

(2014) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

(2014) Jia Ma et al.   TOXICOLOGY LETTERS

microRNAs: key triggers of neuronal cell fate

(2014) Karla F. Meza-Sosa et al.   Frontiers in Cellular Neuroscience

Osthole Reverses Beta-Amyloid Peptide Cytotoxicity on Neural Cells by Enhancing Cyclic AMP Response Element-Binding Protein Phosphorylation

(2013) Yu Hu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Propofol induces rat embryonic neural stem cell apoptosis by activating both extrinsic and intrinsic pathways

(2013) WEI-WEI ZOU et al.   Molecular Medicine Reports

Neurotrophin 3 Transduction Augments Remyelinating and Immunomodulatory Capacity of Neural Stem Cells

(2013) Jingxian Yang et al.   MOLECULAR THERAPY

miR-9: a versatile regulator of neurogenesis

(2013) Marion Coolen et al.   Frontiers in Cellular Neuroscience

Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells

(2013) L Yang et al.   Cell Death & Disease

Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis

(2012) Jingxian Yang et al.   ACTA NEUROPATHOLOGICA

Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells

(2012) Nan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction

(2012) Dongsun Park et al.   EXPERIMENTAL NEUROLOGY

MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain

(2012) Siok-Lay Tan et al.   GENES TO CELLS

MicroRNAs in Alzheimer's disease

(2012) Charlotte Delay et al.   NEUROBIOLOGY OF DISEASE

MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521

(2012) Rui Han et al.   NEUROSCIENCE LETTERS

MicroRNA-9 Modulates Hes1 Ultradian Oscillations by Forming a Double-Negative Feedback Loop

(2012) Boyan Bonev et al.   Cell Reports

Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats

(2011) Yalong He et al.   BRAIN RESEARCH

MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease

(2011) Nicole Schonrock et al.   EXPERIMENTAL NEUROLOGY

MicroRNA-9 promotes differentiation of mouse bone mesenchymal stem cells into neurons by Notch signaling

(2011) Lijun Jing et al.   NEUROREPORT

Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway

(2011) T. Chen et al.   NEUROSCIENCE

NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative auto-regulatory loop

(2011) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

Alzheimer's disease, a multifactorial disorder seeking multitherapies

(2010) Khalid Iqbal et al.   Alzheimers & Dementia

Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation

(2010) Young-Don Kwak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

(2010) I. Imayoshi et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production

(2010) Wen-Bo Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β

(2010) Nicole Schonrock et al.   PLoS One

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1

(2010) Richard D. Smrt et al.   STEM CELLS

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

(2009) Marco Bacigaluppi et al.   BRAIN

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

(2009) Jingxian Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

(2009) Andrew S. Yoo et al.   NATURE

A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination

(2009) Chunnian Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Notch: from neural development to neurological disorders

(2008) Justin D. Lathia et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA-9 Modulates Cajal-Retzius Cell Differentiation by Suppressing Foxg1 Expression in Mouse Medial Pallium

(2008) M. Shibata et al.   JOURNAL OF NEUROSCIENCE