Untangling the roles of RNA helicases in antiviral innate immunity

Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

(2021) Koji Onomoto et al.   Cellular & Molecular Immunology

Dicer represses the interferon response and the double-stranded RNA-activated protein kinase pathway in mouse embryonic stem cells

(2021) Chandan Gurung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

(2021) Taisho Yamada et al.   NATURE IMMUNOLOGY

Human DICER helicase domain recruits PKR and modulates its antiviral activity

(2021) Thomas C. Montavon et al.   PLoS Pathogens

An isoform of Dicer protects mammalian stem cells against multiple RNA viruses

(2021) Enzo Z. Poirier et al.   SCIENCE

DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense

(2020) Frances Taschuk et al.   Viruses-Basel

A Requirement for Argonaute 4 in Mammalian Antiviral Defense

(2020) Fatemeh Adiliaghdam et al.   Cell Reports

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

(2020) Yang Qiu et al.   Science Advances

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

(2020) Kenneth T Farabaugh et al.   eLife

Slicing and dicing viruses: antiviral RNA interference in mammals

(2019) Pierre V Maillard et al.   EMBO JOURNAL

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

(2019) Morgan Brisse et al.   Frontiers in Immunology

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

(2019) Karim Majzoub et al.   Viruses-Basel

No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells

(2019) Susan Schuster et al.   Scientific Reports

IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferons

(2018) Wen Dang et al.   ANTIVIRAL RESEARCH

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

(2018) Zhongmin Liu et al.   CELL

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects

(2018) Enzo Z. Poirier et al.   Cell Host & Microbe

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes

(2018) Zhenfeng Zhang et al.   JOURNAL OF HEPATOLOGY

RNAi-mediated antiviral immunity in mammals

(2018) Ben Berkhout   Current Opinion in Virology

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation

(2018) Antonio Gregorio Dias Junior et al.   TRENDS IN MICROBIOLOGY

Encephalomyocarditis virus 2C protein antagonizes interferon-β signaling pathway through interaction with MDA5

(2018) Liang Li et al.   ANTIVIRAL RESEARCH

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

(2018) Yang Zhao et al.   Nature Communications

Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals

(2017) Yang Qiu et al.   IMMUNITY

The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2

(2017) Suresh K. Kandasamy et al.   RNA

Dicer uses distinct modules for recognizing dsRNA termini

(2017) Niladri K. Sinha et al.   SCIENCE

The Evolution of Antiviral Defense Systems

(2016) Benjamin R. tenOever   Cell Host & Microbe

Inactivation of the type I interferon pathway reveals long double‐stranded RNA‐mediated RNA interference in mammalian cells

(2016) Pierre V Maillard et al.   EMBO JOURNAL

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

(2016) Emiko Uchikawa et al.   MOLECULAR CELL

Partial reconstitution of the RNAi response in human cells using Drosophila gene products

(2016) Edward M. Kennedy et al.   RNA

Development of Antiviral Innate Immunity During In Vitro Differentiation of Mouse Embryonic Stem Cells

(2016) William D'Angelo et al.   STEM CELLS AND DEVELOPMENT

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

(2016) Raul Y Sanchez David et al.   eLife

Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells

(2016) Yang Li et al.   Nature Microbiology

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Sensing viral RNAs by Dicer/RIG-I like ATPases across species

(2015) Simona Paro et al.   CURRENT OPINION IN IMMUNOLOGY

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

MDA5 plays a critical role in interferon response during hepatitis C virus infection

(2015) Xuezhi Cao et al.   JOURNAL OF HEPATOLOGY

ATP-Dependent Effector-like Functions of RIG-I-like Receptors

(2015) Hui Yao et al.   MOLECULAR CELL

Drosophila Dicer-2 Cleavage Is Mediated by Helicase- and dsRNA Termini-Dependent States that Are Modulated by Loquacious-PD

(2015) Niladri K. Sinha et al.   MOLECULAR CELL

Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer

(2015) Edward M. Kennedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors

(2015) Sadeem Ahmad et al.   TRENDS IN BIOCHEMICAL SCIENCES

The molecular basis for functional plasticity in type I interferon signaling

(2015) Gideon Schreiber et al.   TRENDS IN IMMUNOLOGY

Cross-species comparative analysis of Dicer proteins during Sindbis virus infection

(2015) Erika Girardi et al.   Scientific Reports

MDA5 and LGP2: Accomplices and Antagonists of Antiviral Signal Transduction

(2014) K. R. Rodriguez et al.   JOURNAL OF VIROLOGY

Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs

(2014) Hal P. Bogerd et al.   JOURNAL OF VIROLOGY

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

(2014) Yuan Tian et al.   MOLECULAR CELL

A Heritable Antiviral RNAi Response Limits Orsay Virus Infection in Caenorhabditis elegans N2

(2014) Mark G. Sterken et al.   PLoS One

Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens

(2014) Yuchen Nan et al.   Viruses-Basel

RNAi pathways in the recognition of foreign RNA: antiviral responses and host–parasite interactions in nematodes: Figure 1

(2013) Peter Sarkies et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

(2013) Matyas Flemr et al.   CELL

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

Dicer's role as an antiviral: still an enigma

(2013) Christopher R MacKay et al.   CURRENT OPINION IN IMMUNOLOGY

Melanoma Differentiation-Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus Replication

(2013) H.-L. Lu et al.   JOURNAL OF IMMUNOLOGY

RIG-I-Like Receptors Evolved Adaptively in Mammals, with Parallel Evolution at LGP2 and RIG-I

(2013) Rachele Cagliani et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9)

(2013) Qinqin Fu et al.   NUCLEIC ACIDS RESEARCH

The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication

(2013) Guerline Clerzius et al.   Retrovirology

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

(2013) Joao Trindade Marques et al.   PLoS Pathogens

A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

(2013) Alyson Ashe et al.   eLife

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

(2012) Ian C Berke et al.   EMBO JOURNAL

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

(2012) Christopher Wostenberg et al.   PLoS One

MDA5 assembles into a polar helical filament on dsRNA

(2012) I. C. Berke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Duplex RNA activated ATPases (DRAs)

(2012) Dahai Luo et al.   RNA Biology

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease

(2011) Elif Sarinay Cenik et al.   MOLECULAR CELL

Dicer's Helicase Domain Discriminates dsRNA Termini to Promote an Altered Reaction Mode

(2011) Noah C. Welker et al.   MOLECULAR CELL

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recognition of the pre-miRNA structure by Drosophila Dicer-1

(2011) Akihisa Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA interference in Caenorhabditis elegans: Uptake, mechanism, and regulation

(2011) JIMMY J. ZHUANG et al.   PARASITOLOGY

Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions

(2011) Ghislaine Laraki et al.   RNA Biology

RNA helicases

(2011) Arnaz Ranji et al.   RNA Biology

Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses

(2011) Marie-Anne Félix et al.   PLOS BIOLOGY

Biochemical Principles of Small RNA Pathways

(2010) Qinghua Liu et al.   Annual Review of Biochemistry

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing

(2010) Srinivas Chakravarthy et al.   JOURNAL OF MOLECULAR BIOLOGY

Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5/MAVS-Dependent and MDA5/MAVS/RNA Polymerase III-Independent Pathways

(2010) J. Melchjorsen et al.   JOURNAL OF VIROLOGY

Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs

(2010) N. C. Welker et al.   RNA

Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems

(2010) Poornima Parameswaran et al.   PLoS Pathogens

DEAD-box proteins as RNA helicases and chaperones

(2010) Inga Jarmoskaite et al.   Wiley Interdisciplinary Reviews-RNA

Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

(2009) Sylvanne M Daniels et al.   BMC MOLECULAR BIOLOGY

Antiviral immunity in drosophila

(2009) Cordula Kemp et al.   CURRENT OPINION IN IMMUNOLOGY

Requirement for the ERI/DICER Complex in Endogenous RNA Interference and Sperm Development in Caenorhabditis elegans

(2009) Derek M. Pavelec et al.   GENETICS

Multiple Dicer Genes in the Early-Diverging Metazoa

(2009) D. de Jong et al.   MOLECULAR BIOLOGY AND EVOLUTION

Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline

(2009) Weifeng Gu et al.   MOLECULAR CELL

Defective interfering viruses and their potential as antiviral agents

(2009) A. C. Marriott et al.   REVIEWS IN MEDICAL VIROLOGY

RNAi in Budding Yeast

(2009) I. A. Drinnenberg et al.   SCIENCE

Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA

(2009) S. Myong et al.   SCIENCE

RNA-based viral immunity initiated by the Dicer family of host immune receptors

(2008) Roghiyh Aliyari et al.   IMMUNOLOGICAL REVIEWS

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoinhibition of Human Dicer by Its Internal Helicase Domain

(2008) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

(2008) Safia Deddouche et al.   NATURE IMMUNOLOGY