The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2

Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production

(2016) Suresh K. Kandasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Dicer-2 Cleavage Is Mediated by Helicase- and dsRNA Termini-Dependent States that Are Modulated by Loquacious-PD

(2015) Niladri K. Sinha et al.   MOLECULAR CELL

Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer

(2015) Edward M. Kennedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production

(2015) B. W. Han et al.   SCIENCE

piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing

(2014) Bo W. Han et al.   BIOINFORMATICS

A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis

(2014) Ryuya Fukunaga et al.   CELL CYCLE

Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain

(2014) R. Fukunaga et al.   EMBO JOURNAL

Host Control of Insect Endogenous Retroviruses: Small RNA Silencing and Immune Response

(2014) Marie Fablet   Viruses-Basel

The long and short of antiviral defense: small RNA-based immunity in insects

(2014) Alfred W Bronkhorst et al.   Current Opinion in Virology

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

(2013) Matyas Flemr et al.   CELL

RNAi and antiviral defense in Drosophila: Setting up a systemic immune response

(2013) Margot Karlikow et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals

(2013) K. Okamura et al.   GENES & DEVELOPMENT

Roles of R2D2, a Cytoplasmic D2 Body Component, in the Endogenous siRNA Pathway in Drosophila

(2013) Kazumichi M. Nishida et al.   MOLECULAR CELL

Substrate-specific structural rearrangements of human Dicer

(2013) David W Taylor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo

(2012) Shuo Gu et al.   CELL

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(2012) Ryuya Fukunaga et al.   CELL

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

(2012) Christopher Wostenberg et al.   PLoS One

Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease

(2011) Elif Sarinay Cenik et al.   MOLECULAR CELL

Dicer's Helicase Domain Discriminates dsRNA Termini to Promote an Altered Reaction Mode

(2011) Noah C. Welker et al.   MOLECULAR CELL

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

Recognition of the pre-miRNA structure by Drosophila Dicer-1

(2011) Akihisa Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila

(2011) Julia V. Hartig et al.   NUCLEIC ACIDS RESEARCH

Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins

(2010) S. L. Ameres et al.   RNA

Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway

(2009) K. Miyoshi et al.   RNA

Autoinhibition of Human Dicer by Its Internal Helicase Domain

(2008) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

(2008) Yoshinori Kawamura et al.   NATURE

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

(2008) Katsutomo Okamura et al.   NATURE

An endogenous small interfering RNA pathway in Drosophila

(2008) Benjamin Czech et al.   NATURE

Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster

(2008) Katsutomo Okamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells

(2008) M. Ghildiyal et al.   SCIENCE