Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus
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Title
Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus
Authors
Keywords
Cytotoxic T cells, Respiratory infections, Mouse models, Systemic lupus erythematosus, Corticosteroid therapy, Immunopathology, Antiviral therapy, Opportunistic infections
Journal
PLoS Pathogens
Volume 17, Issue 10, Pages e1009858
Publisher
Public Library of Science (PLoS)
Online
2021-10-09
DOI
10.1371/journal.ppat.1009858
References
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Note: Only part of the references are listed.- Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.
- (2021) Laura Bergamaschi et al. IMMUNITY
- Potential of regulatory T cell-based therapies in the management of severe COVID-19
- (2020) Emmanuel Stephen-Victor et al. EUROPEAN RESPIRATORY JOURNAL
- Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
- (2020) Divij Mathew et al. SCIENCE
- Comprehensive mapping of immune perturbations associated with severe COVID-19
- (2020) Leticia Kuri-Cervantes et al. Science Immunology
- Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation
- (2020) Pengcheng Zhou et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Sepsis associated acute kidney injury
- (2019) Jason T Poston et al. BMJ-British Medical Journal
- Risk of Biologics and Glucocorticoids in Patients With Rheumatoid Arthritis Undergoing Arthroplasty
- (2019) Michael D. George et al. ANNALS OF INTERNAL MEDICINE
- CD8+ T cells induce cachexia during chronic viral infection
- (2019) Hatoon Baazim et al. NATURE IMMUNOLOGY
- Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial
- (2019) Jing He et al. ANNALS OF THE RHEUMATIC DISEASES
- Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer
- (2019) Pengcheng Zhou et al. Science Immunology
- Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells
- (2019) Amber Papillion et al. Science Immunology
- Short-term and low-dose IL-2 therapy restores the Th17/Treg balance in the peripheral blood of patients with primary Sjögren’s syndrome
- (2018) Miao Miao et al. ANNALS OF THE RHEUMATIC DISEASES
- Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies
- (2018) Suman Mitra et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
- (2018) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection
- (2018) Megan E. Schmidt et al. PLoS Pathogens
- Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial
- (2018) Michelle Rosenzwajg et al. ANNALS OF THE RHEUMATIC DISEASES
- Molecular mimicry and autoimmunity
- (2018) Manuel Rojas et al. JOURNAL OF AUTOIMMUNITY
- Glucocorticoid-Induced Osteoporosis
- (2018) Lenore Buckley et al. NEW ENGLAND JOURNAL OF MEDICINE
- CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production
- (2017) Fernanda O. Novais et al. PLoS Pathogens
- Risk of serious infections with immunosuppressive drugs and glucocorticoids for lupus nephritis: a systematic review and network meta-analysis
- (2016) Jasvinder A. Singh et al. BMC Medicine
- IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis
- (2016) Stéphanie Humblet-Baron et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus
- (2016) Jing He et al. NATURE MEDICINE
- Common Infections in Patients Prescribed Systemic Glucocorticoids in Primary Care: A Population-Based Cohort Study
- (2016) Laurence Fardet et al. PLOS MEDICINE
- Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
- (2015) Caroline von Spee-Mayer et al. ANNALS OF THE RHEUMATIC DISEASES
- Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes
- (2015) Aixin Yu et al. DIABETES
- Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
- (2015) Michelle Rosenzwajg et al. JOURNAL OF AUTOIMMUNITY
- Human autoimmune diseases: a comprehensive update
- (2015) Lifeng Wang et al. JOURNAL OF INTERNAL MEDICINE
- Serious Infections Among Adult Medicaid Beneficiaries With Systemic Lupus Erythematosus and Lupus Nephritis
- (2015) Candace H. Feldman et al. Arthritis & Rheumatology
- Glucocorticoid treatment in rheumatoid arthritis
- (2014) Rolf Rau EXPERT OPINION ON PHARMACOTHERAPY
- Virus infection, antiviral immunity, and autoimmunity
- (2013) Daniel R. Getts et al. IMMUNOLOGICAL REVIEWS
- IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
- (2013) Georg Gasteiger et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies
- (2013) A Danza et al. LUPUS
- Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
- (2013) Agnès Hartemann et al. Lancet Diabetes & Endocrinology
- Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response
- (2013) Markus Cornberg et al. Frontiers in Immunology
- Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry
- (2012) Sanne A A van Dartel et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation
- (2012) André Ballesteros-Tato et al. IMMUNITY
- Treating Human Autoimmunity: Current Practice and Future Prospects
- (2012) M. D. Rosenblum et al. Science Translational Medicine
- The influence of systemic glucocorticoid therapy upon the risk of non-serious infection in older patients with rheumatoid arthritis: a nested case-control study
- (2011) W. G. Dixon et al. ANNALS OF THE RHEUMATIC DISEASES
- Familial and Acquired Hemophagocytic Lymphohistiocytosis
- (2011) G.E. Janka Annual Review of Medicine
- Incidence and US Costs of Corticosteroid-Associated Adverse Events: A Systematic Literature Review
- (2011) Evelyn Sarnes et al. CLINICAL THERAPEUTICS
- Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction
- (2011) W. Kastenmuller et al. JOURNAL OF IMMUNOLOGY
- Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis
- (2011) David Saadoun et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
- (2011) John Koreth et al. NEW ENGLAND JOURNAL OF MEDICINE
- CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis
- (2011) A. McNally et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation of effector CD8+ T cells and their conversion to memory T cells
- (2010) Weiguo Cui et al. IMMUNOLOGICAL REVIEWS
- Foxp3+ CD4 Regulatory T Cells Limit Pulmonary Immunopathology by Modulating the CD8 T Cell Response during Respiratory Syncytial Virus Infection
- (2010) R. B. Fulton et al. JOURNAL OF IMMUNOLOGY
- Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
- (2010) Qingyong Ji et al. NATURE IMMUNOLOGY
- Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice
- (2009) Jana Pachlopnik Schmid et al. EMBO Molecular Medicine
- Infections and autoimmunity: the multifaceted relationship
- (2009) P. Sfriso et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Infections as triggers and complications of systemic lupus erythematosus
- (2008) A Doria et al. AUTOIMMUNITY REVIEWS
- Risk factors for opportunistic infections in infliximab-treated patients: the importance of screening in prevention
- (2008) C. Garcia-Vidal et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- Control of Virus-Specific CD8+ T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection
- (2008) R. Ou et al. JOURNAL OF VIROLOGY
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