Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer

T follicular helper cells and T follicular regulatory cells in rheumatic diseases

(2019) Jun Deng et al.   Nature Reviews Rheumatology

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells

(2019) Amber Papillion et al.   Science Immunology

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

(2011) J. A. Harker et al.   SCIENCE

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY