Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2

(2016) N. Arenas-Ramirez et al.   Science Translational Medicine

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

History of interleukin-4

(2015) William E. Paul   CYTOKINE

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

(2015) Aixin Yu et al.   DIABETES

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent

(2014) Linda J. Bendall et al.   CYTOKINE & GROWTH FACTOR REVIEWS

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

(2014) Wei Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

Human IL-2 Mutein with Higher Antitumor Efficacy Than Wild Type IL-2

(2013) T. Carmenate et al.   JOURNAL OF IMMUNOLOGY

T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein

(2013) Julien Laurent et al.   Journal of Translational Medicine

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

(2013) Agnès Hartemann et al.   Lancet Diabetes & Endocrinology

Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

(2012) Jian-Xin Lin et al.   IMMUNITY

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

A Brief History of IL-9

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

(2011) Sonia Feau et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

(2010) C. S. Hinrichs et al.   BLOOD

CD8+ Enriched "Young" Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma

(2010) M. E. Dudley et al.   CLINICAL CANCER RESEARCH

Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells

(2010) Federico Simonetta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor   subunit CD25

(2010) S. Letourneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

(2010) C. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia

(2010) Anna Martner et al.   Expert Review of Hematology

Adoptive T cell therapy of cancer

(2009) Ton NM Schumacher et al.   CURRENT OPINION IN IMMUNOLOGY

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets

(2009) Sven Létourneau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo Expansion of Activated Naive CD8+ T Cells and NK Cells Driven by Complexes of IL-2 and Anti-IL-2 Monoclonal Antibody As Novel Approach of Cancer Immunotherapy

(2009) J. Tomala et al.   JOURNAL OF IMMUNOLOGY

Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells

(2009) David V. Liu et al.   JOURNAL OF IMMUNOTHERAPY

High‐dose interleukin‐2 for the treatment of metastatic renal cell carcinoma

(2008) Jacob A. Klapper et al.   CANCER

Janus-Kinase-3-Dependent Signals Induce Chromatin Remodeling at the Ifng Locus during T Helper 1 Cell Differentiation

(2008) Min Shi et al.   IMMUNITY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Many cytokines are very useful therapeutic targets in disease

(2008) Marc Feldmann   JOURNAL OF CLINICAL INVESTIGATION

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity

(2008) Ilkka S. Junttila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blimp-1 directly repressesIl2and theIl2activatorFos, attenuating T cell proliferation and survival

(2008) Gislâine A. Martins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

(2008) Wei Liao et al.   NATURE IMMUNOLOGY

Overcoming obstacles to the effective immunotherapy of human cancer

(2008) S. A. Rosenberg   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology