Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

(2021) Mizuho Fukushige et al.   PLoS Neglected Tropical Diseases

The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species

(2021) J. Mark F. Gardner et al.   PLoS Neglected Tropical Diseases

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity

(2020) Emery Smith et al.   Scientific Reports

Schistosome TRP channels: An appraisal

(2020) Swarna Bais et al.   International Journal for Parasitology-Drugs and Drug Resistance

Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi

(2020) Saurabh Verma et al.   Communications Biology

Recent Progress in TRPM8 Modulation: An Update

(2019) Rosario González-Muñiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

(2019) Sang-Kyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

(2019) Martina Maccesi et al.   Parasites & Vectors

The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP

(2019) Sang-Kyu Park et al.   TRENDS IN PARASITOLOGY

Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers

(2018) Gihan S. Gunaratne et al.   PLoS Neglected Tropical Diseases

Atypical pharmacology of schistosome TRPA1-like ion channels

(2018) Swarna Bais et al.   PLoS Neglected Tropical Diseases

TRP channels as potential targets for antischistosomals

(2018) Swarna Bais et al.   International Journal for Parasitology-Drugs and Drug Resistance

Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception

(2017) Oscar M. Arenas et al.   NATURE NEUROSCIENCE

The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel

(2017) Ramona-Madalina Babes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni

(2016) Nuha R. Mansour et al.   PLoS Neglected Tropical Diseases

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

(2016) John D. Chan et al.   PLoS Pathogens

Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist

(2016) John D. Chan et al.   International Journal for Parasitology-Drugs and Drug Resistance

What is the mechanism of action of praziquantel and how might resistance strike?

(2015) Pauline M Cupit et al.   Future Medicinal Chemistry

Thermosensory Signaling by TRPM Is Processed by Brain Serotonergic Neurons to Produce Planarian Thermotaxis

(2014) T. Inoue et al.   JOURNAL OF NEUROSCIENCE

Ca2+ channels and praziquantel: A view from the free world

(2012) John D. Chan et al.   PARASITOLOGY INTERNATIONAL