What is the mechanism of action of praziquantel and how might resistance strike?

Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel

(2014) Lalit Kumar Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails

(2014) Flávia FB Couto et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

‘Death and Axes’: Unexpected Ca2+ Entry Phenologs Predict New Anti-schistosomal Agents

(2014) John D. Chan et al.   PLoS Pathogens

Praziquantel Treatment Decreases Schistosoma mansoni Genetic Diversity in Experimental Infections

(2013) Regina Coeli et al.   PLoS Neglected Tropical Diseases

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Transcriptional analysis of Schistosoma mansoni treated with praziquantel in vitro

(2012) Jarrett Hines-Kay et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium

(2012) Jean T. Coulibaly et al.   PLoS Neglected Tropical Diseases

Opposing Roles of Voltage-Gated Ca2+ Channels in Neuronal Control of Regenerative Patterning

(2011) D. Zhang et al.   JOURNAL OF NEUROSCIENCE

Resolution of Praziquantel

(2011) Michael Woelfle et al.   PLoS Neglected Tropical Diseases

Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel

(2010) Ravi S. Kasinathan et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum

(2009) Shu-hua Xiao et al.   PARASITOLOGY RESEARCH

A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca2+ Channel β Subunits: Subversion of Flatworm Regenerative Polarity

(2009) Taisaku Nogi et al.   PLoS Neglected Tropical Diseases

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

(2009) Sandra D. Melman et al.   PLoS Neglected Tropical Diseases

Taste, A New Incentive to Switch to (R)-Praziquantel in Schistosomiasis Treatment

(2009) Thorsten Meyer et al.   PLoS Neglected Tropical Diseases

Schistosoma mansoni: Lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death

(2008) Livia Pica-Mattoccia et al.   EXPERIMENTAL PARASITOLOGY

Towards an understanding of the mechanism of action of praziquantel

(2008) Anthony D. Aragon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY