The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways

(2019) Sergey Yegorov et al.   Nature Communications

TRPM2: a candidate therapeutic target for treating neurological diseases

(2018) Jillian Corinne Belrose et al.   ACTA PHARMACOLOGICA SINICA

Praziquantel Interaction with Mammalian Targets in the Spotlight

(2018) Tim A. Day et al.   TRENDS IN PARASITOLOGY

Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers

(2018) Gihan S. Gunaratne et al.   PLoS Neglected Tropical Diseases

Atypical pharmacology of schistosome TRPA1-like ion channels

(2018) Swarna Bais et al.   PLoS Neglected Tropical Diseases

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

The Mechanism of Action of Praziquantel: Six Hypotheses

(2018) Charlotte M. Thomas et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structures and gating mechanism of human TRPM2

(2018) Longfei Wang et al.   SCIENCE

In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium

(2017) Jana Kovač et al.   Parasites & Vectors

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel

(2017) Ramona-Madalina Babes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

(2017) John D. Chan et al.   Nature Communications

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

(2017) Robert Bergquist et al.   Infectious Diseases of Poverty

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

(2016) John D. Chan et al.   PLoS Pathogens

TRP channels in schistosomes

(2016) Swarna Bais et al.   International Journal for Parasitology-Drugs and Drug Resistance

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

(2016) Frank J. P. Kühn et al.   PLoS One

New approaches for understanding mechanisms of drug resistance in schistosomes

(2013) ROBERT M. GREENBERG   PARASITOLOGY

Resolution of Praziquantel

(2011) Michael Woelfle et al.   PLoS Neglected Tropical Diseases

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

(2009) Jianyang Du et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Schistosomiasis in Africa: An Emerging Tragedy in Our New Global Health Decade

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Schistosoma mansoni: Lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death

(2008) Livia Pica-Mattoccia et al.   EXPERIMENTAL PARASITOLOGY