Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers

In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium

(2017) Jana Kovač et al.   Parasites & Vectors

The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel

(2017) Ramona-Madalina Babes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ion channel mechanisms of rat tail artery contraction-relaxation by menthol involving, respectively, TRPM8 activation and L-type Ca2+ channel inhibition

(2016) Donal Melanaphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators

(2016) Alessia Bertamino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer

(2016) M. Jesús Pérez de Vega et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

(2016) John D. Chan et al.   PLoS Pathogens

What is the mechanism of action of praziquantel and how might resistance strike?

(2015) Pauline M Cupit et al.   Future Medicinal Chemistry

Ergot Alkaloids (Re)generate New Leads as Antiparasitics

(2015) John D. Chan et al.   PLoS Neglected Tropical Diseases

Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni

(2015) Swarna Bais et al.   PLoS Neglected Tropical Diseases

TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation

(2015) Darizy Flavia Silva et al.   PLoS One

Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni

(2014) Isabel Meister et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activation of Cold-Sensing Transient Receptor Potential Melastatin Subtype 8 Antagonizes Vasoconstriction and Hypertension Through Attenuating RhoA/Rho Kinase Pathway

(2014) Jing Sun et al.   HYPERTENSION

The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)

(2014) P. Olliaro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives

(2014) Yuko Terada et al.   JOURNAL OF NATURAL PRODUCTS

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

(2013) David J. Beech   CIRCULATION JOURNAL

TRPA1 channels in the vasculature

(2012) Scott Earley   BRITISH JOURNAL OF PHARMACOLOGY

Emerging role of G protein-coupled receptors in microvascular myogenic tone

(2012) G. Kauffenstein et al.   CARDIOVASCULAR RESEARCH

Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity

(2012) Sevvandi Senadheera et al.   CARDIOVASCULAR RESEARCH

Ca2+ channels and praziquantel: A view from the free world

(2012) John D. Chan et al.   PARASITOLOGY INTERNATIONAL

Opposing Roles of Voltage-Gated Ca2+ Channels in Neuronal Control of Regenerative Patterning

(2011) D. Zhang et al.   JOURNAL OF NEUROSCIENCE

Resolution of Praziquantel

(2011) Michael Woelfle et al.   PLoS Neglected Tropical Diseases

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

5-Benzyloxytryptamine as an antagonist of TRPM8

(2010) Jeff DeFalco et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Africa is desperate for praziquantel

(2010) Peter J Hotez et al.   LANCET

Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone

(2009) Christopher D. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

(2009) K. Nozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schistosomiasis in Africa: An Emerging Tragedy in Our New Global Health Decade

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Taste, A New Incentive to Switch to (R)-Praziquantel in Schistosomiasis Treatment

(2009) Thorsten Meyer et al.   PLoS Neglected Tropical Diseases

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes

(2008) Sohag N. Saleh et al.   JOURNAL OF PHYSIOLOGY-LONDON