Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes

(2020) Ines Martic et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

(2019) Ruchi Sharma et al.   Science Translational Medicine

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice

(2019) Michael Landowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructural analysis of submacular choriocapillaris and its transport systems in AMD and aged control eyes

(2019) Rhonda Grebe et al.   EXPERIMENTAL EYE RESEARCH

Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization

(2019) Nathaniel Parsons et al.   MOLECULAR IMMUNOLOGY

Early local activation of complement in aqueous humour of patients with age-related macular degeneration

(2019) L. Altay et al.   EYE

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

(2019) Andrew P. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

(2019) Diana Pauly et al.   Cell Reports

Genome-wide analysis of disease progression in age-related macular degeneration

(2018) Qi Yan et al.   HUMAN MOLECULAR GENETICS

Complement factor H in AMD: Bridging genetic associations and pathobiology

(2018) Christopher B. Toomey et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Subretinal Drusenoid Deposits AKA Pseudodrusen

(2018) Richard F. Spaide et al.   SURVEY OF OPHTHALMOLOGY

C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway

(2018) Rosario Fernandez-Godino et al.   Scientific Reports

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells

(2018) Helen Louise May-Simera et al.   Cell Reports

Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration

(2018) Frank G. Holz et al.   JAMA Ophthalmology

Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration

(2018) Anna C. S. Tan et al.   Science Translational Medicine

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

(2017) Seth R Flaxman et al.   Lancet Global Health

Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease

(2016) Jevgenia Zilberman-Rudenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications

(2016) Kiyoharu J. Miyagishima et al.   Stem Cells Translational Medicine

Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration

(2016) Johanna M. Seddon et al.   JAMA Ophthalmology

A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells

(2016) A. Kleijn et al.   Stem Cells International

The use of fluorescent Nile red and BODIPY for lipid measurement in microalgae

(2015) Judith Rumin et al.   Biotechnology for Biofuels

Age-related macular degeneration: genome-wide association studies to translation

(2015) James R. M. Black et al.   GENETICS IN MEDICINE

Complement Component 3 Is Regulated by TWIST1 and Mediates Epithelial–Mesenchymal Transition

(2015) Min Soon Cho et al.   JOURNAL OF IMMUNOLOGY

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Regulation of age-related macular degeneration-like pathology by complement factor H

(2015) Christopher B. Toomey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation

(2014) Kannan Kunchithapautham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

(2014) Khandakar A.S.M. Saadat et al.   FEBS Open Bio

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

(2013) Chang Luo et al.   EXPERIMENTAL EYE RESEARCH

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

(2013) Annika Mehlem et al.   Nature Protocols

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

(2011) L. V. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells

(2010) Kapil Bharti et al.   Pigment Cell & Melanoma Research

Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration

(2009) Christine A. Curcio et al.   JOURNAL OF LIPID RESEARCH

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Dopamine D4 receptors regulate intracellular calcium concentration in cultured chicken cone photoreceptor cells: Relationship to dopamine receptor-mediated inhibition of cAMP formation

(2008) Tamara N. Ivanova et al.   BRAIN RESEARCH