Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

(2014) Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner

(2013) Kusumam Joseph et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of complement activation using monoclonal antibodies against C3d

(2013) Joshua M. Thurman et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Classification of Age-related Macular Degeneration

(2013) Frederick L. Ferris et al.   OPHTHALMOLOGY

Alternative Complement Pathway Deficiency Ameliorates Chronic Smoke-Induced Functional and Morphological Ocular Injury

(2013) Alex Woodell et al.   PLoS One

Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration

(2012) Katayoon B Ebrahimi et al.   JOURNAL OF PATHOLOGY

Biological Effects of Cigarette Smoke in Cultured Human Retinal Pigment Epithelial Cells

(2012) Alice L. Yu et al.   PLoS One

Respiratory epithelial cell responses to cigarette smoke: The unfolded protein response

(2012) Steven G. Kelsen   PULMONARY PHARMACOLOGY & THERAPEUTICS

The endocrine effects of nicotine and cigarette smoke

(2012) Jesse Oliver Tweed et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy

(2011) Susan D. Vogt et al.   EXPERIMENTAL EYE RESEARCH

Endoplasmic reticulum stress and lipid dysregulation

(2011) Stephen M. Colgan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Modified Low Density Lipoprotein Stimulates Complement C3 Expression and Secretion via Liver X Receptor and Toll-like Receptor 4 Activation in Human Macrophages

(2011) Denis A. Mogilenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

(2011) L. V. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Cigarette smoke extract stimulates interleukin-8 production in human airway epithelium and is attenuated by superoxide dismutase in vitro

(2010) Ryan M. Mulligan et al.   American Journal of Rhinology & Allergy

Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site

(2010) Fabrizio Damiano et al.   BIOCHEMICAL JOURNAL

Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation

(2010) J. Damman et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage

(2010) Kara S. Davis et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

PATHWAY-BASED THERAPIES FOR AGE-RELATED MACULAR DEGENERATION

(2010) Marco A Zarbin et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Do We Need a New Classification for Choroidal Neovascularization in Age-Related Macular Degeneration?

(2010) K Bailey Freund et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Complement Factor H Is Critical in the Maintenance of Retinal Perfusion

(2009) Peter Lundh von Leithner et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration

(2009) Kurt M. Bertram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

(2009) Joshua M. Thurman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Esterified Cholesterol Is Highly Localized to Bruch's Membrane, as Revealed by Lipid Histochemistry in Wholemounts of Human Choroid

(2009) Martin Rudolf et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach

(2009) Mohd Danishuddin et al.   JOURNAL OF MOLECULAR MODELING

Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection

(2009) Yoshihito Ishida et al.   MOLECULAR BIOLOGY OF THE CELL

Changes in Retinal Pigment Epithelium Related to Cigarette Smoke: Possible Relevance to Smoking as a Risk Factor for Age-Related Macular Degeneration

(2009) Ai Ling Wang et al.   PLoS One

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Environmental tobacco smoke exposure and eye disease

(2008) N Lois et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Regulated complement deposition on the surface of human endothelial cells: Effect of tobacco smoke and shear stress

(2008) Wei Yin et al.   THROMBOSIS RESEARCH