Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

The role of autophagy in the regulation of yeast life span

(2018) Jessica K. Tyler et al.   Annals of the New York Academy of Sciences

Impaired cohesion and homologous recombination during replicative aging in budding yeast

(2018) Sangita Pal et al.   Science Advances

Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1

(2017) Cornelia Kurischko et al.   MOLECULAR BIOLOGY OF THE CELL

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

(2017) Nitish Mittal et al.   Nature Communications

Nucleolar expansion and elevated protein translation in premature aging

(2017) Abigail Buchwalter et al.   Nature Communications

Ribosome Footprint Profiling of Translation throughout the Genome

(2016) Nicholas T. Ingolia   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

Rapamycin extends life- and health span because it slows aging

(2016) Mikhail V. Blagosklonny   Aging-US

The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time

(2016) Georges E. Janssens et al.   PLoS One

Restriction of protein synthesis abolishes senescence features at cellular and organismal levels

(2016) Yuki Takauji et al.   Scientific Reports

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

(2015) Payel Sen et al.   GENES & DEVELOPMENT

The Overlooked Fact: Fundamental Need for Spike-In Control for Virtually All Genome-Wide Analyses

(2015) Kaifu Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan

(2015) Ata Ghavidel et al.   PLoS Genetics

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage

(2014) Adva Aizer et al.   JOURNAL OF CELL SCIENCE

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

Diverse Functions of mRNA Metabolism Factors in Stress Defense and Aging of Caenorhabditis elegans

(2014) Aris Rousakis et al.   PLoS One

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

(2013) Jordan Gallinetti et al.   BIOCHEMICAL JOURNAL

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

(2012) Joe R. Delaney et al.   AGING CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

DANPOS: Dynamic analysis of nucleosome position and occupancy by sequencing

(2012) K. Chen et al.   GENOME RESEARCH

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1

(2011) Cornelia Kurischko et al.   JOURNAL OF CELL BIOLOGY

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Cbk1 Regulation of the RNA-Binding Protein Ssd1 Integrates Cell Fate with Translational Control

(2009) Jaclyn M. Jansen et al.   CURRENT BIOLOGY

The Mother Enrichment Program: A Genetic System for Facile Replicative Life Span Analysis in Saccharomyces cerevisiae

(2009) D. L. Lindstrom et al.   GENETICS

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity

(2008) J. R. Managbanag et al.   PLoS One

Ageing and the regulation of protein synthesis: a balancing act?

(2008) Nektarios Tavernarakis   TRENDS IN CELL BIOLOGY

Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System

(2008) Daniel J Hogan et al.   PLOS BIOLOGY