Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo

Pyridoxamine ameliorates methylglyoxal‐induced macrophage dysfunction to facilitate tissue repair in diabetic wounds

(2021) Minfei Jiang et al.   International Wound Journal

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

(2020) Hai-Jian Sun et al.   Frontiers in Pharmacology

The Role of Reactive Oxygen Species in Arsenic Toxicity

(2020) Yuxin Hu et al.   Biomolecules

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

(2020) Marie-Eve Piché et al.   CIRCULATION RESEARCH

Genetics of diabetes mellitus and diabetes complications

(2020) Joanne B. Cole et al.   Nature Reviews Nephrology

Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

(2020) Xiaoling Chen et al.   NEUROPHARMACOLOGY

Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells

(2020) Soyoung Kwak et al.   American Journal of Rhinology & Allergy

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro

(2020) Jie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Trans, trans-2,4-decadienal impairs vascular endothelial function by inducing oxidative/nitrative stress and apoptosis

(2020) Yuanyuan Hu et al.   Redox Biology

Isosamidin from Peucedanum japonicum Roots Prevents Methylglyoxal-Induced Glucotoxicity in Human Umbilical Vein Endothelial Cells via Suppression of ROS-Mediated Bax/Bcl-2

(2020) Moon Ho Do et al.   Antioxidants

Sodium–glucose cotransporter type 2 inhibitors for the treatment of type 2 diabetes mellitus

(2020) André J. Scheen   Nature Reviews Endocrinology

Protective Effect of Geraniol on Oxidative, Inflammatory and Apoptotic Alterations in Isoproterenol-Induced Cardiotoxicity: Role of the Keap1/Nrf2/HO-1 and PI3K/Akt/mTOR Pathways

(2020) Nancy S. Younis et al.   Antioxidants

Glyoxalase System in the Progression of Skin Aging and Skin Malignancies

(2020) Silvia Yumnam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway

(2020) Shiyong Wu et al.   JOURNAL OF DRUG TARGETING

The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis

(2020) Sana S. Hasan et al.   TRENDS IN CELL BIOLOGY

Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation

(2020) Lidia de Bari et al.   Antioxidants

FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E‐cadherin and CD44 expression

(2019) Yuling Hong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Randomized Trial of Magnesium Oxide and Oral Carbon Adsorbent for Coronary Artery Calcification in Predialysis CKD

(2019) Yusuke Sakaguchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells

(2019) Qian Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic reprogramming in atherosclerosis: Opposed interplay between the canonical WNT/β-catenin pathway and PPARγ

(2019) Alexandre Vallée et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Endothelial Response to Pathophysiological Stress

(2019) Zekun Peng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protective effect of metformin against palmitate-induced hepatic cell death

(2019) Yana Geng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis

(2019) Qining Yang et al.   PHARMACOLOGICAL RESEARCH

Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications

(2019) Elisa Dal Canto et al.   European Journal of Preventive Cardiology

Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway

(2019) Fengwei Nan et al.   MOLECULAR AND CELLULAR PROBES

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways

(2018) Hailong Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advanced glycation end products in the pathogenesis of chronic kidney disease

(2018) Naila Rabbani et al.   KIDNEY INTERNATIONAL

Metformin and Autoimmunity: A “New Deal” of an Old Drug

(2018) Francesco Ursini et al.   Frontiers in Immunology

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

(2018) Joanna Kalucka et al.   Cell Metabolism

Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro

(2018) Shanshan Cui et al.   Redox Biology

Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation

(2017) Bee Ooi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Primary Prevention of Cardiovascular Disease in Diabetes Mellitus

(2017) Jonathan D. Newman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasminogen activator inhibitor-1 regulates the vascular expression of vitronectin

(2017) M. Luo et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells

(2017) Ningbo Pang et al.   Oxidative Medicine and Cellular Longevity

The role of cPLA2 in Methylglyoxal-induced cell apoptosis of HUVECs

(2017) Jie Yuan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux

(2017) Johanna Zemva et al.   Redox Biology

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

(2016) Yuan Ying et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells

(2016) Baoping Jiang et al.   FREE RADICAL RESEARCH

Nrf2 mediates redox adaptations to exercise

(2016) Aaron J. Done et al.   Redox Biology

The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation

(2015) Wenlu Li et al.   JOURNAL OF NEUROCHEMISTRY

Attenuation of methylglyoxal-induced peritoneal fibrosis: immunomodulation by interleukin-10

(2015) Akira Onishi et al.   LABORATORY INVESTIGATION

Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo

(2014) Cecilia Nigro et al.   DIABETOLOGIA

High levels of IgM against methylglyoxal-modified apolipoprotein B100 are associated with less coronary artery calcification in patients with type 2 diabetes

(2011) D. Engelbertsen et al.   JOURNAL OF INTERNAL MEDICINE

Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and -8 in Caco-2 cells

(2009) Sabine Kuntz et al.   EUROPEAN JOURNAL OF NUTRITION