Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Angina: contemporary diagnosis and management

(2020) Thomas Joseph Ford et al.   HEART

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

(2020) Ganhua You et al.   Drug Design Development and Therapy

Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways

(2019) Yishi Wang et al.   LIFE SCIENCES

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

(2019) Fan Bai et al.   Lipids in Health and Disease

Intermittent Hypoxia Induces Autophagy to Protect Cardiomyocytes From Endoplasmic Reticulum Stress and Apoptosis

(2019) Jui-Chih Chang et al.   Frontiers in Physiology

Autophagy-A key pathway for cardiac health and longevity

(2018) B. P. Woodall et al.   Acta Physiologica

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Metformin reduces TRIB3 expression and restores autophagy flux: an alternative antitumor action

(2018) Ke Li et al.   Autophagy

Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury

(2018) Nawal M. Al-Rasheed et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy

(2018) Shiyong Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy

(2018) Rita Zilinyi et al.   MOLECULES

Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After Exposure to Hypoxia and Oxidative Stress via Upregulating Cell Autophagy

(2018) Han-hua Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux

(2018) Xiaoqian Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection

(2018) Venkateswara Rao Amara et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway

(2017) Yanyan Du et al.   GENE

Sanggenon C protects against cardiomyocyte hypoxia injury by increasing autophagy

(2017) Yang Gu et al.   Molecular Medicine Reports

Knockdown of MicroRNA-122 Protects H9c2 Cardiomyocytes from Hypoxia-Induced Apoptosis and Promotes Autophagy

(2017) Zaiwei Zhang et al.   MEDICAL SCIENCE MONITOR

Aliskiren Improves Ischemia- and Oxygen Glucose Deprivation-Induced Cardiac Injury through Activation of Autophagy and AMP-Activated Protein Kinase

(2017) Ming-Hsien Chiang et al.   Frontiers in Pharmacology

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Autophagy in cardiovascular biology

(2015) Sergio Lavandero et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of autophagic degradation in the heart

(2015) Kazuhiko Nishida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of autophagy during ischemia/reperfusion

(2014) Junichi Sadoshima   Autophagy

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

(2013) Emanuele Marzetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Long-term survival in patients with refractory angina

(2013) T. D. Henry et al.   EUROPEAN HEART JOURNAL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Metformin improves cardiac function in rats via activation of AMP-activated protein kinase

(2010) Xiao-Fang Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Autophagy in Ischemic Heart Disease

(2009) Åsa B. Gustafsson et al.   CIRCULATION RESEARCH

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY