Article
Biochemistry & Molecular Biology
Xu Zhao, Jiancong Lu, Xuebing Chen, Zhengxiang Gao, Cui Zhang, Chuanxiang Chen, Dongfang Qiao, Huijun Wang
Summary: The study identified the molecular mechanisms of METH-induced neuronal programmed necrosis, showing that RIP3 plays a crucial role in the process and could be a potential therapeutic target for METH-induced neurotoxicity.
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
Helena R. Moreira, Daniel B. Rodrigues, Sara Freitas-Ribeiro, Lucilia P. da Silva, Alain da S. Morais, Mariana Jarnalo, Ricardo Horta, Rui L. Reis, Rogerio P. Pirraco, Alexandra P. Marques
Summary: Prevascularization in vitro is a method to promote engineered tissue vascularization. Prevascularized constructs delayed re-epithelization of wounds, possibly due to persistent inflammation and slower healing process.
MATERIALS TODAY BIO
(2022)
Article
Medicine, Research & Experimental
Jingjing Zhang, Jianan Qian, Wei Zhang, Xianfen Chen
Summary: Recent studies have found that RIPK3 plays a significant role in mediating myocardial necroptosis through CaMK II phosphorylation and oxidation. Inhibition of CaMK II activity can effectively reduce RIPK3-mediated necroptosis. Necroptosis has been shown to be important in the development of cardiovascular diseases. Selective inhibitor GSK '872 of RIPK3 can effectively inhibit the occurrence and development of cardiovascular diseases and reverse cardiac dysfunction caused by RIPK3 overexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Yuka Azuma, Kazuhiko Uchiyama, Takeshi Sugaya, Takeshi Yasuda, Hikaru Hashimoto, Mariko Kajiwara-Kubota, Satoshi Sugino, Hiroaki Kitae, Takashi Torii, Katsura Mizushima, Toshifumi Doi, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yuji Naito, Yoshito Itoh
Summary: The study revealed that the expression of TGR5 was decreased in the colonic epithelium of mice with DSS-induced colitis and UC patients, and DCA can delay wound healing in YAMC cells. Inhibiting the AKT signaling pathway can prevent the wound healing delay induced by DCA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Eunhwan Kim, Yumi Hwang, Heejene Kim, Geon-Uk Kim, Yeong Chan Ryu, Minguen Yoon, Kang-Yell Choi
Summary: In this study, the researchers found that the activation of the Wnt/beta-catenin signaling pathway increases PKM2 expression and pyruvate kinase (PK) activity during wound healing in mice. They also discovered that the allosteric activator of PKM2, TEPP-46, enhances keratinocyte migration and wound healing. Furthermore, the combination of TEPP-46 and a Wnt/beta-catenin signaling activator, KY19382, significantly accelerates wound healing and induces angiogenesis in the wound beds.
Article
Cell Biology
Stuart J. Mills, Parinaz Ahangar, Hannah M. Thomas, Benjamin R. Hofma, Rachael Z. Murray, Allison J. Cowin
Summary: TLR4 and Flii play crucial roles in inflammation and tissue repair. Elevated Flii reduces early TLR4 expression, impairing healing, while reduced Flii contributes to early healing.
Review
Physiology
Olga Krizanova, Adela Penesova, Jozef Sokol, Alica Hokynkova, Amir Samadian, Petr Babula
Summary: This review outlines new possibilities for cutaneous wound healing through modulation of signaling molecules, with a specific focus on gasotransmitters and calcium. It also highlights the importance of addressing chronic wounds caused by diabetes and inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jianghui Qin, Fang Chen, Pingli Wu, Guoming Sun
Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Kehinde Ross
Summary: miRNAs play a critical role in wound healing, particularly in influencing the behavior of epidermal keratinocytes. Combining multiple miRNA mimics targeting different but complementary wound healing processes may be more effective in promoting wound repair.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Su Hyun Jung, Bong Hwan Jang, Seyong Kwon, Sung Jin Park, Tae-Eun Park, Joo H. Kang
Summary: Autologous implantable scaffolds using autologous whole blood are effective in promoting skin wound healing by constructing robust microcapillary vessel networks. Microfluidic shear stresses enable the alignment of bundled fibrin fibers and the activation of platelets, facilitating endothelial cell maturation and vascularization. Rodent dorsal skin wounds patched with IVET exhibit superior wound closure rates, epidermis thickness, collagen deposition, hair follicle numbers, and neutrophil infiltration, attributed to enhanced microvascular circulation. Moreover, IVET treatment accelerates wound healing by recruiting M2 phenotype macrophages.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Yuzhen Wang, Xingyu Yuan, Bin Yao, Shuoji Zhu, Ping Zhu, Sha Huang
Summary: This review discusses the potential and limitations of extrusion-based bioprinting (EBB) for skin regeneration, and introduces strategies for improving the physical properties of bioinks and reinforcing bioinks in EBB approaches. It highlights the applications and effects of current EBB-based bioinks on wound healing, wound scar formation, vascularization, and the regeneration of skin appendages, along with the challenges and future perspectives.
BIOACTIVE MATERIALS
(2022)
Review
Biology
Lucas Fernando Sergio Gushiken, Fernando Pereira Beserra, Jairo Kenupp Bastos, Christopher John Jackson, Claudia Helena Pellizzon
Summary: The article discusses the physiological mechanisms, interfering factors, and treatment methods of skin wound healing. The success of wound healing depends on the correct balance and is influenced by various factors.
Article
Biochemistry & Molecular Biology
Yuyun Hua, Jianan Qian, Ji Cao, Xue Wang, Wei Zhang, Jingjing Zhang
Summary: This study found that AGEs stimulation increased the expression of RIPK3, aggravated the disorder of CaMKII delta alternative splicing, promoted CaMKII activation, enhanced oxidative stress, induced necroptosis, and damaged cardiomyocytes. Downregulation of RIPK3 or inhibition of RIPK3 with GSK '872 corrected the disorder of CaMKII delta alternative splicing, inhibited CaMKII activation, reduced oxidative stress, attenuated necroptosis, and improved cell damage in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ian Stoppa, Casimiro Luca Gigliotti, Nausicaa Clemente, Deepika Pantham, Chiara Dianzani, Chiara Monge, Chiara Puricelli, Roberta Rolla, Salvatore Sutti, Filippo Reno, Renzo Boldorini, Elena Boggio, Umberto Dianzani
Summary: This study found that ICOS-Fc can improve skin wound healing by promoting angiogenesis and recruitment of reparative macrophages. This suggests that the ICOS/ICOSL network plays an important role in tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kehong Chen, Atsushi Murao, Adnan Arif, Satoshi Takizawa, Hui Jin, Jianxin Jiang, Monowar Aziz, Ping Wang
Summary: In sepsis, eCIRP-induced NETs inhibit phagocytosis of apoptotic cells by macrophages through neutrophil elastase-dependent reduction of integrins. This discovery reveals a potential mechanism of therapeutic failure.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Cell Biology
Chuyi Tan, Monowar Aziz, Ping Wang
Summary: This review discusses the formation, function, and impact of neutrophil extracellular traps (NETs) on the body, emphasizing recent advancements in identifying novel pathways and mechanisms of NET formation, as well as the specific damaging impact of NETs in different organs.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Health Care Sciences & Services
Siavash Bolourani, Max Brenner, Ping Wang, Thomas McGinn, Jamie S. Hirsch, Douglas Barnaby, Theodoros P. Zanos
Summary: This study aimed to predict respiratory failure within 48 hours of admission for COVID-19 patients using a machine learning model. The XGBoost model showed higher accuracy compared to other models and early warning scores, with important predictor variables such as oxygen delivery method, patient age, and Emergency Severity Index level.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Immunology
Chuyi Tan, Bridgette Reilly, Alok Jha, Atsushi Murao, Yongchan Lee, Max Brenner, Monowar Aziz, Ping Wang
Summary: This study suggests that eCIRP is actively released from viable macrophages through GSDMD pores. Inhibition of GSDMD can reduce the release of eCIRP and potentially inhibit eCIRP-mediated inflammation in sepsis.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Surgery
Sara Siskind, William Royster, Max Brenner, Ping Wang
Summary: Inhibiting the extracellular cold-inducible RNA-binding protein/triggering receptor expressed on myeloid cells-1 pathway with M3 attenuates acute kidney injury, indicating that M3 could be a potential therapeutic agent for treating acute kidney injury.
Article
Biochemistry & Molecular Biology
Satoshi Takizawa, Yongchan Lee, Asha Jacob, Monowar Aziz, Ping Wang
Summary: This study found that eCIRP induces trogocytosis of neutrophils during inflammation, and the trogocytosed neutrophils exhibit an exaggerated pro-inflammatory phenotype.
MOLECULAR MEDICINE
(2022)
Review
Cell Biology
Colleen P. Nofi, Ping Wang, Monowar Aziz
Summary: This article focuses on a subgroup of endogenous molecules, known as chromatin-associated molecular patterns (CAMPs), which can be detected as foreign and trigger immune signaling pathways. The release of CAMPs from cells, their mechanism of action and downstream immune signaling pathways, as well as targeted therapeutic approaches to mitigate inflammation and tissue injury, are reviewed.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Kensuke Murata, Atsushi Murao, Monowar Aziz, Ping Wang
Summary: Neutrophil heterogeneity in sepsis is a significant factor, and the extracellular cold-inducible RNA-binding protein (eCIRP) regulates neutrophil phenotype and function through TLR4. This study found that eCIRP can induce CD112 expression in neutrophils, promoting Th1 differentiation in sepsis.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Cassie Shu Zhu, Xiaoling Qiang, Weiqiang Chen, Jianhua Li, Xiqian Lan, Huan Yang, Jonathan Gong, Lance Becker, Ping Wang, Kevin J. Tracey, Haichao Wang
Summary: The expression and secretion of procathepsin-L (pCTS-L) induced by serum amyloid A (SAA) contributes to its late and systemic accumulation in sepsis. Inhibition of pCTS-L interaction may be a potential antibody-based strategy to prevent dysregulated immune responses mediated by late-acting cytokines.
Article
Neurosciences
Archna Sharma, Ezgi Sari, Yongchan Lee, Shivani Patel, Max Brenner, Philippe Marambaud, Ping Wang
Summary: Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have been implicated in neurogenerative diseases. The current study investigates how eCIRP regulates the signaling pathways involved in calcium and calpain, and uncovers a novel mechanism involving Ca2+ release from ER stores in an IL-6R alpha/PLC/IP3-dependent manner.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Surgery
Molly Kobritz, Colleen Nofi, Maria Sfakianos, Gene Coppa, Monowar Aziz, Ping Wang
Summary: H151 has the potential to therapeutically reduce acute intestinal injury in sepsis.
Article
Medicine, Research & Experimental
Hui Jin, Monowar Aziz, Atsushi Murao, Molly Kobritz, Andrew J. Shih, Robert P. Adelson, Max Brenner, Ping Wang
Summary: Extracellular cold-inducible RNA-binding protein (eCIRP) is a key factor in the severity and mortality of sepsis, which induces the formation of antigen-presenting aged neutrophils (APANs) through CD4+ T cell activation, Th1 polarization, and IFN-gamma-mediated hyper-NETosis. APANs exacerbate acute lung injury (ALI) and worsen the survival of septic animals. These findings highlight the role of eCIRP and APANs in sepsis pathogenesis and potential therapeutic targets.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Physiology
Zhijian Hu, Fangming Zhang, Max Brenner, Asha Jacob, Ping Wang
Summary: Renal ischemia-reperfusion (RIR)-induced acute kidney injury (AKI) is a common renal disorder with high morbidity and mortality. STING is a signaling pathway that mediates inflammation and injury through cytosolic DNA activation. eCIRP, a damage-associated molecular pattern, activates STING and worsens hemorrhagic shock. H151, a small molecule, inhibits eCIRP-induced STING activation in vitro and protects against RIR-induced AKI.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Timothy Borjas, Asha Jacob, Molly Kobritz, Gaifeng Ma, Chuyi Tan, Vihas Patel, Gene F. F. Coppa, Monowar Aziz, Ping Wang
Summary: This study investigates the potential of a synthetic miRNA called PS-OMe miR130 in inhibiting eCIRP-mediated inflammation and acute lung injury in sepsis. The results show that PS-OMe miR130 has a strong binding affinity to eCIRP, decreases inflammatory proteins, and improves survival in a murine model of sepsis. This synthetic miRNA, with enhanced stability and protection from nuclease activity, holds promise as a novel therapeutic approach.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Mian Zhou, Monowar Aziz, Hao-Ting Yen, Gaifeng Ma, Atsushi Murao, Ping Wang
Summary: In this study, we identified a novel mechanism by which eCIRP impairs macrophage bacterial phagocytosis in sepsis. Increased eCIRP levels were associated with decreased bacterial clearance in infected mice. eCIRP inhibited actin remodeling in macrophages through the formation of a STAT3-beta PIX complex, resulting in phagocytic dysfunction. Inhibition of STAT3 rescued the macrophage phagocytic dysfunction induced by eCIRP.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)