Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials

Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody

(2021) Shiwen Peng et al.   mBio

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

(2021) Noa Dagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model

(2021) Alejandra G. Martinez-Perez et al.   Vaccines

The dawn of mRNA vaccines: The COVID-19 case

(2021) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Emerging concepts in the science of vaccine adjuvants

(2021) Bali Pulendran et al.   NATURE REVIEWS DRUG DISCOVERY

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

(2021) Emily H. Pilkington et al.   Acta Biomaterialia

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

(2021) Nicola P. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses

(2021) Matin Kayyal et al.   MOLECULAR BIOTECHNOLOGY

Role of nanotechnology behind the success of mRNA vaccines for COVID-19

(2021) Amit Khurana et al.   Nano Today

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

(2021) Christiane S. Eberhardt et al.   NATURE

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

(2021) Noam Barda et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices — United States, July 2021

(2021) Hannah G. Rosenblum et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial

(2021) Noor Alida Maria Bakker et al.   Journal for ImmunoTherapy of Cancer

A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications

(2021) Furong Qin et al.   Frontiers in Cell and Developmental Biology

Novel Antigenic Targets of HPV Therapeutic Vaccines

(2021) Ditte Rahbæk Boilesen et al.   Vaccines

Development of HPV16,18,31,45 E5 and E7 peptides-based vaccines predicted by immunoinformatics tools

(2020) Ali Namvar et al.   BIOTECHNOLOGY LETTERS

Early-stage cervical cancer diagnosis based on an ultra-sensitive electrochemical DNA nanobiosensor for HPV-18 detection in real samples

(2020) Pegah Mahmoodi et al.   JOURNAL OF NANOBIOTECHNOLOGY

HPV vaccination and cancer prevention

(2020) A. Athanasiou et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients

(2020) Kunal H. Bhatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A quality improvement collaborative to increase human papillomavirus vaccination rates in local health department clinics

(2020) Rachel Wallace-Brodeur et al.   PREVENTIVE MEDICINE

Nanoplasmid Vectors Co-expressing Innate Immune Agonists Enhance DNA Vaccines for Venezuelan Equine Encephalitis Virus and Ebola Virus

(2020) John J. Suschak et al.   Molecular Therapy-Methods & Clinical Development

881TiP A multi-centre, open-label phase II trial of the combination of VB10.16 and atezolizumab in patients with advanced or recurrent, non-resectable HPV16 positive cervical cancer

(2020) P. Hillemanns et al.   ANNALS OF ONCOLOGY

A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC)

(2020) J. Chandra et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The effectiveness of human papillomavirus load, reflected by cycle threshold values, for the triage of HPV-positive self-samples in cervical cancer screening

(2020) Fangbin Song et al.   JOURNAL OF MEDICAL SCREENING

Evolution of the COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Experimental Nanovaccine Offers Protection Against Repeat Exposures to Trypanosoma cruzi Through Activation of Polyfunctional T Cell Response

(2020) Imran H. Chowdhury et al.   Frontiers in Immunology

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

(2019) Aurelie Hanoteau et al.   Journal for ImmunoTherapy of Cancer

Rapid Clearance Profile of Plasma Circulating Tumor HPV Type 16 DNA during Chemoradiotherapy Correlates with Disease Control in HPV-Associated Oropharyngeal Cancer

(2019) Bhishamjit S Chera et al.   CLINICAL CANCER RESEARCH

Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China

(2019) Jiaoyu He et al.   Virology Journal

The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled phase II trial with 2.5 years of follow-up

(2019) Diane M. Harper et al.   GYNECOLOGIC ONCOLOGY

The promise of combining cancer vaccine and checkpoint blockade for treating HPV-related cancer

(2019) Takeo Shibata et al.   CANCER TREATMENT REVIEWS

Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System

(2019) Chenhao Zhou et al.   Frontiers in Oncology

A phase 2, prospective, randomized, multicenter, open-label study of GX-188E, an HPV DNA vaccine, in patients with cervical intraepithelial neoplasia 3

(2019) Youn Jin Choi et al.   CLINICAL CANCER RESEARCH

Comparison of DNA and mRNA vaccines against cancer

(2019) Zohreh Jahanafrooz et al.   DRUG DISCOVERY TODAY

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

(2018) Ying-Li Luo et al.   ACS Nano

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Current research into novel therapeutic vaccines against cervical cancer

(2018) Marcelo Nazário Cordeiro et al.   Expert Review of Anticancer Therapy

Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)

(2018) Daniel Boda et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Oral manifestations of human papillomavirus infections

(2018) Stina Syrjänen   EUROPEAN JOURNAL OF ORAL SCIENCES

A comprehensive in silico analysis for identification of therapeutic epitopes in HPV16, 18, 31 and 45 oncoproteins

(2018) Heidar Ali Panahi et al.   PLoS One

DNA Vaccines—How Far From Clinical Use?

(2018) Dominika Hobernik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

Immune evasion mechanisms of human papillomavirus: An update

(2017) Alina Steinbach et al.   INTERNATIONAL JOURNAL OF CANCER

Cohort Profile: African Collaborative Center for Microbiome and Genomics Research’s (ACCME's) Human Papillomavirus (HPV) and Cervical Cancer Study

(2017) Sally N Adebamowo et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model

(2017) Ying Ma et al.   VACCINE

Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7

(2017) Kwong Y. Tsang et al.   VACCINE

In vivo electroporation enhances vaccine-mediated therapeutic control of human papilloma virus-associated tumors by the activation of multifunctional and effector memory CD8 + T cells

(2017) Natiely S. Sales et al.   VACCINE

Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus

(2017) Andrew Yang et al.   Cell and Bioscience

Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment

(2016) Allan Hildesheim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Cervical cancer: A comprehensive approach towards extermination

(2016) Smitha V. Bava et al.   ANNALS OF MEDICINE

Synergistic effect of programmed cell death protein 1 blockade and secondary lymphoid tissue chemokine in the induction of anti-tumor immunity by a therapeutic cancer vaccine

(2016) Soheila Moeini et al.   ARCHIVES OF VIROLOGY

Utilizing selection biomarkers in clinical trials: is this the future of drug development?

(2016) Adam Carroll   Biomarkers in Medicine

CD27 Agonism Plus PD-1 Blockade Recapitulates CD4+ T-cell Help in Therapeutic Anticancer Vaccination

(2016) T. Ahrends et al.   CANCER RESEARCH

Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation

(2016) Tomonori Yaguchi et al.   INTERNATIONAL IMMUNOLOGY

Identification of immunotherapeutic epitope of E5 protein of human papillomavirus-16: An in silico approach

(2015) Anoop Kumar et al.   BIOLOGICALS

HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms

(2015) Rodrigo dos Santos Francisco et al.   IMMUNOGENETICS

Pathogenesis of human papillomavirus-associated mucosal disease

(2015) Ian J Groves et al.   JOURNAL OF PATHOLOGY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

Tumor-infiltrating lymphocytes for the treatment of metastatic cancer

(2015) M.H. Geukes Foppen et al.   Molecular Oncology

Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity

(2015) Alice O. Kamphorst et al.   VACCINE

Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia

(2015) Nagayasu Egawa et al.   Viruses-Basel

Codon Optimization of the Human Papillomavirus E7 Oncogene Induces a CD8+ T Cell Response to a Cryptic Epitope Not Harbored by Wild-Type E7

(2015) Felix K. M. Lorenz et al.   PLoS One

Design, Immune Responses and Anti-Tumor Potential of an HPV16 E6E7 Multi-Epitope Vaccine

(2015) Liliane Maria Fernandes de Oliveira et al.   PLoS One

Regression of Human Papillomavirus Intraepithelial Lesions Is Induced by MVA E2 Therapeutic Vaccine

(2014) Ricardo Rosales et al.   HUMAN GENE THERAPY

Identification of novel epitopes from human papillomavirus type 18 E7 that can sensitize PBMCs of multiple HLA class I against human cervical cancer

(2014) Sunghoon Kim et al.   Journal of Translational Medicine

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

(2014) Tae Jin Kim et al.   Nature Communications

Anti-tumor effects of genetic vaccines against HPV major oncogenes

(2014) Marcelo Nazário Cordeiro et al.   Human Vaccines & Immunotherapeutics

Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer

(2013) M J Ward et al.   BRITISH JOURNAL OF CANCER

HPV16 E5 peptide vaccine in treatment of cervical cancer in vitro and in vivo

(2013) Shu-jie Liao et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer

(2013) Rui Jun Lin et al.   Journal of Otolaryngology-Head & Neck Surgery

Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions

(2012) Isabelle Soerjomataram et al.   LANCET

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis

(2012) Catherine de Martel et al.   LANCET ONCOLOGY

HPV: The global burden

(2012) James Mitchell Crow   NATURE

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

(2012) M. L. Bagarazzi et al.   Science Translational Medicine

Global Burden of Human Papillomavirus and Related Diseases

(2012) David Forman et al.   VACCINE

The Biology and Life-Cycle of Human Papillomaviruses

(2012) John Doorbar et al.   VACCINE

Identification of novel immunogenic human leukocyte antigen-A*2402-binding epitopes of human papillomavirus type 16 E7 for immunotherapy against human cervical cancer

(2011) Sunphil Jang et al.   CANCER

Molecular and cellular mechanisms of DNA vaccines

(2011) Cevayir Coban et al.   Human vaccines & immunotherapeutics

Identification of HLA-A11-restricted CTL epitopes derived from HPV type 18 using DNA immunization

(2010) Hsin-Wei Chen et al.   CANCER BIOLOGY & THERAPY

Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies

(2010) Sheila V Graham   Future Microbiology

Comparison of the immunogenicity and safety ofCervarix™ andGardasil®human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18–45 years

(2010) Mark H. Einstein et al.   Human vaccines & immunotherapeutics

Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens inCervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

(2010) Michel Deschuyteneer et al.   Human vaccines & immunotherapeutics

Therapeutic HPV DNA vaccines

(2010) Ken Lin et al.   IMMUNOLOGIC RESEARCH

The biological properties of E6 and E7 oncoproteins from human papillomaviruses

(2009) Raffaella Ghittoni et al.   VIRUS GENES

Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques

(2008) Jian Yan et al.   VACCINE

Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen

(2008) Jian Yan et al.   VACCINE

WHO meeting on the standardization of HPV assays and the role of the WHO HPV Laboratory Network in supporting vaccine introduction held on 24–25 January 2008, Geneva, Switzerland

(2008) Morag Ferguson et al.   VACCINE