Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

(2018) Dietmar Herndler-Brandstetter et al.   IMMUNITY

T-cell modulation by cyclophosphamide for tumour therapy

(2018) Ellyn Hughes et al.   IMMUNOLOGY

Quantitative Analysis of Immune Infiltrates in Primary Melanoma

(2018) Robyn D. Gartrell et al.   Cancer Immunology Research

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

(2018) Jared M. Newton et al.   Jove-Journal of Visualized Experiments

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

(2018) Takanori Kitamura et al.   Frontiers in Immunology

Using Visualization oft-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors

(2017) Nicole V. Acuff et al.   JOURNAL OF IMMUNOLOGY

Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

(2017) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors

(2017) Benjamin Frey et al.   Frontiers in Immunology

Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

(2017) Aurélie Hanoteau et al.   OncoImmunology

Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients

(2017) H. van Meir et al.   OncoImmunology

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer

(2016) Vishwajith Sridharan et al.   BRITISH JOURNAL OF CANCER

Checkpoint Antibodies but not T Cell-Recruiting Diabodies Effectively Synergize with TIL-Inducing  -Irradiation

(2016) M. Hettich et al.   CANCER RESEARCH

Human Head and Neck Squamous Cell Carcinoma–Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells

(2016) Rania H. Younis et al.   JOURNAL OF IMMUNOLOGY

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer

(2016) Ruth J. Davis et al.   ORAL ONCOLOGY

Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses

(2016) Marij J. Welters et al.   Science Translational Medicine

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis

(2016) Daniel W. Vermeer et al.   Oncotarget

Old-School Chemotherapy in Immunotherapeutic Combination in Cancer, A Low-cost Drug Repurposed

(2016) R. Abu Eid et al.   Cancer Immunology Research

A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma

(2016) Todd Crocenzi et al.   Journal for ImmunoTherapy of Cancer

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Consensus nomenclature for CD8+T cell phenotypes in cancer

(2015) Lionel Apetoh et al.   OncoImmunology

Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences

(2014) P Balermpas et al.   BRITISH JOURNAL OF CANCER

iNOS Expression in CD4+ T Cells Limits Treg Induction by Repressing TGF 1: Combined iNOS Inhibition and Treg Depletion Unmask Endogenous Antitumor Immunity

(2014) P. Jayaraman et al.   CLINICAL CANCER RESEARCH

Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome

(2014) T. Matsunaga et al.   FREE RADICAL RESEARCH

HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis

(2014) Cathy Ndiaye et al.   LANCET ONCOLOGY

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy

(2013) Saly Al-Taei et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Effects of Adjuvant Chemoradiotherapy on the Frequency and Function of Regulatory T Cells in Patients with Head and Neck Cancer

(2013) P. J. Schuler et al.   CLINICAL CANCER RESEARCH

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2Kd-specific CD8+T cells

(2013) Gwendoline Rahir et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release

(2012) P. Jayaraman et al.   JOURNAL OF IMMUNOLOGY

Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer

(2012) Shao Hui Huang et al.   ORAL ONCOLOGY

Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome

(2011) Yingzi Ge et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

Reduction of nitric oxide level enhances the radiosensitivity of hypoxic non-small cell lung cancer

(2011) Wael Saleem et al.   CANCER SCIENCE

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Selective Changes in the Immune Profile of Tumor-Draining Lymph Nodes After Different Neoadjuvant Chemoradiation Regimens for Locally Advanced Cervical Cancer

(2010) Alessandra Battaglia et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

HPV-associated head and neck cancer: a virus-related cancer epidemic

(2010) Shanthi Marur et al.   LANCET ONCOLOGY

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus–Related Head and Neck Cancer

(2009) William C. Spanos et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Switch from perforin-expressing to perforin-deficient CD8+T cells accounts for two distinct types of effector cytotoxic T lymphocytesin vivo

(2009) Avihai Meiraz et al.   IMMUNOLOGY

Effect of HPV-Associated p16INK4A Expression on Response to Radiotherapy and Survival in Squamous Cell Carcinoma of the Head and Neck

(2009) Pernille Lassen et al.   JOURNAL OF CLINICAL ONCOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE