Differentiation of the tumor microenvironment: are CAFs the Organizer?

Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity

(2021) Tuxiong Huang et al.   GUT

Nrg1/ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K/Akt pathway

(2021) Fei Lu et al.   NEUROSCIENCE LETTERS

Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis

(2021) Hyunho Yoon et al.   ONCOGENE

Redefining macrophage and neutrophil biology in the metastatic cascade

(2021) Esra Güç et al.   IMMUNITY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Wnt5a in cancer-associated fibroblasts promotes colorectal cancer progression

(2021) Tomoaki Hirashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual role of WNT5A in promoting endothelial differentiation of glioma stem cells and angiogenesis of glioma derived endothelial cells

(2021) Taoliang Chen et al.   ONCOGENE

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

(2021) Xiaoqi Mao et al.   Molecular Cancer

Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic

(2021) Amit Grover et al.   Cancer Discovery

Mechanistic insights of adipocyte metabolism in regulating breast cancer progression

(2020) Fuchuang Zhang et al.   PHARMACOLOGICAL RESEARCH

ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

(2020) Sarah Theresa Boyle et al.   NATURE CELL BIOLOGY

Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

(2020) Denise Gay et al.   Science Advances

Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

(2020) Zeda Zhang et al.   CANCER CELL

Tumour-directed microenvironment remodelling at a glance

(2020) Sarah T. Boyle et al.   JOURNAL OF CELL SCIENCE

Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

(2020) Richard Lee Barrett et al.   eLife

The pericyte microenvironment during vascular development

(2019) Laura B. Payne et al.   MICROCIRCULATION

Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers

(2019) Tze-Sian Chan et al.   Frontiers in Oncology

Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer

(2019) Takashi Aizawa et al.   Cancer Medicine

High COX‐2 expression in cancer‐associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma

(2019) Yinghong Zhu et al.   MOLECULAR CARCINOGENESIS

Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study

(2018) D Gramatzki et al.   ANNALS OF ONCOLOGY

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

On the nature and function of organizers

(2018) Alfonso Martinez Arias et al.   DEVELOPMENT

The controversial role of mast cells in fibrosis

(2018) Peter Bradding et al.   IMMUNOLOGICAL REVIEWS

Rho–ROCK signaling regulates tumor-microenvironment interactions

(2018) Mohammad Zahied Johan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies

(2018) David A. Mahvi et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation

(2017) Mandy Leist et al.   EXPERIMENTAL DERMATOLOGY

Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents

(2017) Minfeng Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

(2017) Balaji Krishnamachary et al.   Oncotarget

β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

(2016) Maria Mastrogiannaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pericyte–fibroblast transition promotes tumor growth and metastasis

(2016) Kayoko Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus and characterization of immature neurons along the septotemporal axis

(2016) Ian Mahar et al.   Scientific Reports

The Hedgehog pathway: role in cell differentiation, polarity and proliferation

(2015) Yanfei Jia et al.   ARCHIVES OF TOXICOLOGY

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

(2015) Jasreen Kular et al.   DEVELOPMENTAL CELL

Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice

(2015) R. Singh et al.   MOLECULAR CANCER RESEARCH

Gene expression profile of normal and cancer-associated fibroblasts according to intratumoral inflammatory cells phenotype from breast cancer tissue

(2015) Lucía González et al.   MOLECULAR CARCINOGENESIS

Overexpression of NRG1 promotes progression of gastric cancer by regulating the self-renewal of cancer stem cells

(2014) Myoung-Eun Han et al.   JOURNAL OF GASTROENTEROLOGY

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Angiogenesis in Glioblastoma

(2013) Sunit Das et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

(2013) T. Marichal et al.   Cancer Immunology Research

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment

(2012) Y. Zhang et al.   CANCER RESEARCH

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Vascular Wall-Resident CD44+ Multipotent Stem Cells Give Rise to Pericytes and Smooth Muscle Cells and Contribute to New Vessel Maturation

(2011) Diana Klein et al.   PLoS One

Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1

(2010) Kakali Dhar et al.   Molecular Cancer

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

Adipogenic, Chondrogenic and Osteogenic Differentiation of Clonally Derived Human Dermal Fibroblasts

(2009) Johan P.E. Junker et al.   CELLS TISSUES ORGANS

Forcing cells to change lineages

(2009) Thomas Graf et al.   NATURE

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Snail is required for TGF -induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

(2008) T. Kokudo et al.   JOURNAL OF CELL SCIENCE