Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation

(2018) Aimy Sebastian et al.   GENE

M2 macrophages promote wound-induced hair neogenesis

(2018) Akira Kasuya et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

(2018) Chae Ho Lim et al.   Nature Communications

The critical role of macrophages in the pathogenesis of hidradenitis suppurativa

(2017) Ahmed Shah et al.   INFLAMMATION RESEARCH

Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin’s EDA Domain

(2017) Rhiannon M. Kelsh-Lasher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

(2017) Michael Sigal et al.   NATURE

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

(2017) Xusheng Wang et al.   Nature Communications

Diversity and Versatility of Phagocytosis: Roles in Innate Immunity, Tissue Remodeling, and Homeostasis

(2017) Justin J. Lim et al.   Frontiers in Cellular and Infection Microbiology

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB

(2016) Matthew A. Gray et al.   CURRENT BIOLOGY

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

(2016) Emanuel Rognoni et al.   DEVELOPMENT

Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease

(2016) Manolis Roulis et al.   DIFFERENTIATION

CD301b + Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

(2016) Yosuke Kumamoto et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer

(2016) Joanna M. Poczobutt et al.   JOURNAL OF IMMUNOLOGY

β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

(2016) Maria Mastrogiannaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

(2016) Rui Martins et al.   NATURE IMMUNOLOGY

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

Microbiota of the Small Intestine Is Selectively Engulfed by Phagocytes of the Lamina Propria and Peyer’s Patches

(2016) Masatoshi Morikawa et al.   PLoS One

Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

(2015) Chih-Chiang Chen et al.   CELL

Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury

(2015) Dikshya Bastakoty et al.   FASEB JOURNAL

PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

(2015) Tomoaki Iwayama et al.   GENES & DEVELOPMENT

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

CD133 Expression Correlates with Membrane Beta-Catenin and E-Cadherin Loss from Human Hair Follicle Placodes during Morphogenesis

(2015) Denise L. Gay et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes

(2015) Emily Hamburg-Shields et al.   JOURNAL OF PATHOLOGY

Pathophysiology of hidradenitis suppurativa: An update

(2015) Errol Prens et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

(2015) Boris Hinz   MATRIX BIOLOGY

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Macrophages decide between regeneration and fibrosis in muscle

(2015) Pura Muñoz-Cánoves et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

(2015) Ziad Julier et al.   Scientific Reports

Immune Modulation of Stem Cells and Regeneration

(2014) Arin B. Aurora et al.   Cell Stem Cell

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-Like Receptor Signaling

(2014) S. Bhattacharyya et al.   Science Translational Medicine

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

Dermal  -catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

(2012) D. Chen et al.   DEVELOPMENT

Sustained β-Catenin Activity in Dermal Fibroblasts Is Sufficient for Skin Fibrosis

(2012) Emily J. Hamburg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The myofibroblast matrix: implications for tissue repair and fibrosis

(2012) Franco Klingberg et al.   JOURNAL OF PATHOLOGY

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt Signaling and Dupuytren's Disease

(2011) Guido H. Dolmans et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

(2008) P. Bovolenta et al.   JOURNAL OF CELL SCIENCE