Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play

MRN complex is an essential effector of DNA damage repair

(2021) Shan Qiu et al.   Journal of Zhejiang University-SCIENCE B

Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics

(2021) Victor M. Matias-Barrios et al.   Frontiers in Oncology

New insights into small‐cell lung cancer development and therapy

(2020) Yuwen Wang et al.   CELL BIOLOGY INTERNATIONAL

Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks

(2020) Karol Szlachta et al.   NUCLEIC ACIDS RESEARCH

Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group

(2020) Takeshi Saito et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks

(2020) Talia Hatkevich et al.   NUCLEIC ACIDS RESEARCH

NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation

(2019) Roopesh Anand et al.   EMBO JOURNAL

Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling

(2019) Romain Duval et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide

(2019) Qing Nian et al.   MOLECULAR PHARMACOLOGY

A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

(2019) Zhengang Qiu et al.   Drug Design Development and Therapy

Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms

(2019) Masataka Tsuda et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

(2018) Harshal Nemade et al.   ARCHIVES OF TOXICOLOGY

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites

(2018) Takeshi Yasuda et al.   PLoS Genetics

Benzene metabolite 1,2,4-benzenetriol changes DNA methylation and histone acetylation of erythroid-specific genes in K562 cells

(2018) Chun-Hong Yu et al.   ARCHIVES OF TOXICOLOGY

Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review

(2017) Naoki Shimada et al.   INTERNAL MEDICINE

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches

(2017) Amanda C. Winters et al.   Frontiers in Pediatrics

Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα

(2016) Elizabeth G. Gibson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

(2016) Judy L. Bolton et al.   CHEMICAL RESEARCH IN TOXICOLOGY

TC-PTP and PTP1B: Regulating JAK–STAT signaling, controlling lymphoid malignancies

(2016) Kelly A. Pike et al.   CYTOKINE

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities ofEP300andCREBBP

(2016) Maoxiang Qian et al.   GENOME RESEARCH

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

Benzoquinone toxicity is not prevented by sulforaphane in CD-1 mouse fetal liver cells

(2015) Nicola A. Philbrook et al.   JOURNAL OF APPLIED TOXICOLOGY

The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis

(2015) Xiao-Jian Sun et al.   Frontiers in Oncology

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

(2014) Nicholas A. Smith et al.   BIOCHEMISTRY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spectroscopic detection of etoposide binding to chromatin components: The role of histone proteins

(2014) Elham Chamani et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage

(2014) Anuranjani et al.   Redox Biology

Etoposide Catechol Is an Oxidizable Topoisomerase II Poison

(2013) David A. Jacob et al.   CHEMICAL RESEARCH IN TOXICOLOGY

STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

(2013) K A Dorritie et al.   LEUKEMIA

Phytochemicals as anticancer and chemopreventive topoisomerase II poisons

(2013) Adam C. Ketron et al.   PHYTOCHEMISTRY REVIEWS

Double-Strand Break Repair Assays Determine Pathway Choice and Structure of Gene Conversion Events in Drosophila melanogaster

(2013) Anthony T. Do et al.   G3-Genes Genomes Genetics

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Carboplatin- or Cisplatin-Based Chemotherapy in First-Line Treatment of Small-Cell Lung Cancer: The COCIS Meta-Analysis of Individual Patient Data

(2012) Antonio Rossi et al.   JOURNAL OF CLINICAL ONCOLOGY

EMA/CO for High-Risk Gestational Trophoblastic Neoplasia: Good Outcomes With Induction Low-Dose Etoposide-Cisplatin and Genetic Analysis

(2012) Constantine Alifrangis et al.   JOURNAL OF CLINICAL ONCOLOGY

Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor

(2012) Sachiko Ezoe   International Journal of Environmental Research and Public Health

Etoposide Quinone Is a Redox-Dependent Topoisomerase II Poison

(2011) David A. Jacob et al.   BIOCHEMISTRY

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis

(2011) S. N. Zimmer et al.   BLOOD

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma

(2011) M. Kleppe et al.   HAEMATOLOGICA

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels

(2010) Cliona M. McHale et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Topoisomerase II-Mediated DNA Damage Is Differently Repaired during the Cell Cycle by Non-Homologous End Joining and Homologous Recombination

(2010) Marcelo de Campos-Nebel et al.   PLoS One

Benzene-initiated oxidative stress: Effects on embryonic signaling pathways

(2009) Helen J. Badham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Topoisomerase II inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms

(2009) Scott Mondrala et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms

(2009) Cliona M. McHale et al.   GENOMICS

Etoposide pathway

(2009) Jun Yang et al.   Pharmacogenetics and Genomics

The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells

(2008) Roopam Singh et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH