Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching

(2019) Masataka Tsuda et al.   PLoS One

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes

(2018) Hiroyuki Sasanuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links

(2017) Matthew J. Schellenberg et al.   SCIENCE

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2

(2016) Christophe Marchand et al.   ACS Chemical Biology

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

(2016) Nguyen Ngoc Hoa et al.   MOLECULAR CELL

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

(2016) Kiran Kumar Naidu Guturi et al.   Nature Communications

DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway

(2015) Margaret Tammaro et al.   NUCLEIC ACIDS RESEARCH

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

(2014) Fernando Gómez-Herreros et al.   NATURE GENETICS

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

(2013) Margaret Tammaro et al.   PLoS One

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

(2012) Matthew J Schellenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2

(2012) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Detection of DNA–protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs

(2012) Mahmoud I. Shoulkamy et al.   NUCLEIC ACIDS RESEARCH

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

(2012) K. C. Lee et al.   Biology Open

Interfacial inhibitors: targeting macromolecular complexes

(2011) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

(2010) Kyoko Nakamura et al.   PLoS Genetics

A Novel Approach Using DNA-Repair–Deficient Chicken DT40 Cell Lines for Screening and Characterizing the Genotoxicity of Environmental Contaminants

(2009) Kyunghee Ji et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

(2009) Edgar Hartsuiker et al.   MOLECULAR CELL

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex – A Potentially New Drug Target

(2009) Iris Alchanati et al.   PLoS One