TNF in the liver: targeting a central player in inflammation

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

(2021) Dan-in Jang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis

(2021) Tobias Poch et al.   JOURNAL OF HEPATOLOGY

Circulating tumor necrosis factor‐α levels in non‐alcoholic fatty liver disease: A systematic review and a meta‐analysis

(2021) Victoria Potoupni et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

(2021) Heather J. Cordell et al.   JOURNAL OF HEPATOLOGY

Infliximab-induced liver injury: Clinical phenotypes, autoimmunity and the role of corticosteroid treatment.

(2021) Helgi Kristinn Björnsson et al.   JOURNAL OF HEPATOLOGY

Insights into the biology and therapeutic implications of TNF and regulatory T cells

(2021) Benoit L. Salomon   Nature Reviews Rheumatology

Role of bile acids in inflammatory liver diseases

(2021) Ioannis Evangelakos et al.   Seminars in Immunopathology

Novel therapeutic targets for cholestatic and fatty liver disease

(2021) Michael Trauner et al.   GUT

Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies

(2021) Youngmin A. Lee et al.   JOURNAL OF INTERNAL MEDICINE

Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis

(2020) C.R.H. Hedin et al.   Clinical Gastroenterology and Hepatology

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

(2020) Franziska Wandrer et al.   Cell Death & Disease

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

(2020) Roman Fischer et al.   Frontiers in Cell and Developmental Biology

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

(2020) Sandra Lampl et al.   JOURNAL OF HEPATOLOGY

Gut microbiome in primary sclerosing cholangitis: A review

(2020) Rebecca Little et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis

(2020) Martin Kummen et al.   GASTROENTEROLOGY

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis

(2019) Muhammad Farooq et al.   Cell Death & Disease

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

CCL21-expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis

(2019) Annika E. Langeneckert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis

(2019) Fabian Glaser et al.   JOURNAL OF HEPATOLOGY

Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice

(2019) Gevitha Ravichandran et al.   JOURNAL OF HEPATOLOGY

TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis

(2019) Claudia S. Bovensiepen et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

(2019) Wen-Yi Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF activity and T cells

(2018) Amit K. Mehta et al.   CYTOKINE

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease

(2018) Dana Tedesco et al.   GASTROENTEROLOGY

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

(2018) Yingjie Nie et al.   Science Signaling

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

(2018) Yingjie Nie et al.   Science Signaling

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

(2018) Loris Lopetuso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond

(2018) Catherine Dostert et al.   PHYSIOLOGICAL REVIEWS

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Distinct Kinase-Independent Role of RIPK3 in CD11c + Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

(2017) Kenta Moriwaki et al.   Cell Reports

TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis

(2017) Jan Kempski et al.   Frontiers in Immunology

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2016) Ana L. Gomes et al.   CANCER CELL

Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors

(2016) Yong Kwang Park et al.   JOURNAL OF HEPATOLOGY

A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis

(2016) Katrin Neumann et al.   JOURNAL OF IMMUNOLOGY

CD4 + T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood

(2016) Tanja Schoknecht et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection

(2016) Marc Beyer et al.   NATURE IMMUNOLOGY

Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

(2016) Ulrike Billmeier et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice

(2016) Stefaan Verhulst et al.   Scientific Reports

Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model

(2015) I-Tsu Chyuan et al.   Cellular & Molecular Immunology

The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver

(2015) Muhammad Imran Arshad et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infliximab as a treatment option for patients with rheumatoid arthritis and primary biliary cirrhosis

(2015) Despoina Dimopoulou et al.   RHEUMATOLOGY INTERNATIONAL

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

(2014) Ynto S. de Boer et al.   GASTROENTEROLOGY

Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms

(2014) Marcial Sebode et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus Core Protein Sensitizes Hepatocytes to Tumor Necrosis Factor-Induced Apoptosis by Suppression of the Phosphorylation of Mitogen-Activated Protein Kinase Kinase 7

(2014) Baosen Jia et al.   JOURNAL OF VIROLOGY

TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model

(2013) F J Cubero et al.   CELL DEATH AND DIFFERENTIATION

Liver Injury From Tumor Necrosis Factor-α Antagonists: Analysis of Thirty-four Cases

(2013) Marwan Ghabril et al.   Clinical Gastroenterology and Hepatology

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

(2013) Janosch Katt et al.   HEPATOLOGY

Tumor necrosis factor α (TNF-α) receptor-I is required for TNF-α-mediated fulminant virus hepatitis caused by murine hepatitis virus strain-3 infection

(2013) Huan Xu et al.   IMMUNOLOGY LETTERS

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Hepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-κB

(2012) Junseong Park et al.   HEPATOLOGY

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis

(2012) Christina Weiler-Normann et al.   JOURNAL OF HEPATOLOGY

Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes

(2012) Sabrina Sieber et al.   PLoS One

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis

(2011) Muhammad I. Arshad et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury

(2011) Christian Liedtke et al.   GASTROENTEROLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells

(2011) Xin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure

(2011) Hanno Ehlken et al.   PLoS One

A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis

(2008) Nicholas C. Boetticher et al.   GASTROENTEROLOGY

Adalimumab Could Suppress the Activity of Non Alcoholic Steatohepatitis (NASH)

(2008) C Schramm et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE