APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

Lipids and Alzheimer’s Disease

(2020) Yu-Chia Kao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

APOE and dementia – resequencing and genotyping in 105,597 individuals

(2020) Katrine L. Rasmussen et al.   Alzheimers & Dementia

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease

(2020) Chia‐Chen Liu et al.   Alzheimers & Dementia

Dementia with Lewy bodies: an update and outlook

(2019) Tiago Fleming Outeiro et al.   Molecular Neurodegeneration

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort

(2019) Octavio A. Santos et al.   Alzheimers & Dementia

α-synuclein in the pathophysiology of Alzheimer’s disease

(2019) Daniel Twohig et al.   Molecular Neurodegeneration

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

(2019) Iliya Lefterov et al.   Alzheimers Research & Therapy

ApoE facilitates the microglial response to amyloid plaque pathology

(2018) Jason D. Ulrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

(2016) Mitsuru Shinohara et al.   ACTA NEUROPATHOLOGICA

Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease

(2016) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Novel advances in shotgun lipidomics for biology and medicine

(2016) Miao Wang et al.   PROGRESS IN LIPID RESEARCH

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

(2016) Chia-Chen Liu et al.   Science Translational Medicine

Clinicopathologic and11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

(2015) Melissa E. Murray et al.   BRAIN

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Rarity of the Alzheimer Disease–ProtectiveAPPA673T Variant in the United States

(2015) Li-San Wang et al.   JAMA Neurology

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

(2014) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study

(2014) Clifford R Jack et al.   LANCET NEUROLOGY

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease

(2014) Christopher W Medway et al.   Molecular Neurodegeneration

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

(2014) Chia-Chen Liu et al.   NEURON

Phosphatidylserine in the brain: Metabolism and function

(2014) Hee-Yong Kim et al.   PROGRESS IN LIPID RESEARCH

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

(2013) C. R. Jack et al.   NEUROLOGY

VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies

(2013) Zhenjun Hu et al.   NUCLEIC ACIDS RESEARCH

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

(2012) Pritam Das et al.   Molecular Neurodegeneration

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease

(2012) C. Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

Dissociation of Apolipoprotein E Oligomers to Monomer Is Required for High-Affinity Binding to Phospholipid Vesicles

(2011) Kanchan Garai et al.   BIOCHEMISTRY

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol

(2011) Sandhya Sankaranarayanan et al.   JOURNAL OF LIPID RESEARCH

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

(2011) Katherine Lynn Youmans et al.   JOURNAL OF NEUROSCIENCE METHODS

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

The Association−Dissociation Behavior of the ApoE Proteins: Kinetic and Equilibrium Studies

(2010) Kanchan Garai et al.   BIOCHEMISTRY

Automated Lipid Identification and Quantification by Multidimensional Mass Spectrometry-Based Shotgun Lipidomics

(2009) Kui Yang et al.   ANALYTICAL CHEMISTRY

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

The Role and Metabolism of Sulfatide in the Nervous System

(2008) Matthias Eckhardt   MOLECULAR NEUROBIOLOGY

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

(2008) Hua Cheng et al.   NEUROBIOLOGY OF AGING

Microfluidics-based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: development of an automated high-throughput platform for shotgun lipidomics

(2008) Xianlin Han et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY