CTD of SARS‐CoV ‐2 N protein is a cryptic domain for binding ATP and nucleic acid that interplay in modulating phase separation

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

(2021) Shan Lu et al.   Nature Communications

ATP biphasically modulates LLPS of SARS-CoV-2 nucleocapsid protein and specifically binds its RNA-binding domain

(2021) Mei Dang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

(2021) Pengfei Wang et al.   NATURE

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

(2021) Yuyang Lei et al.   CIRCULATION RESEARCH

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

(2021) Liguo Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP regulates RNA ‐driven CIRBP phase separation

(2021) Qishun Zhou et al.   PROTEIN SCIENCE

Adenosine triphosphate energy‐independently controls protein homeostasis with unique structure and diverse mechanisms

(2021) Jianxing Song   PROTEIN SCIENCE

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

(2021) Willianne Hoepel et al.   Science Translational Medicine

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

(2021) Yafei Liu et al.   CELL

Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase

(2021) Tae Hun Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues

(2021) Mei Dang et al.   Communications Biology

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2

(2020) Luca Zinzula et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

1H, 13C, and 15N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein

(2020) Sophie M. Korn et al.   Biomolecular NMR Assignments

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

(2020) Christopher R. Carlson et al.   MOLECULAR CELL

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

(2020) Christiane Iserman et al.   MOLECULAR CELL

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

(2020) Adriana Savastano et al.   Nature Communications

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

(2020) Dhurvas Chandrasekaran Dinesh et al.   PLoS Pathogens

Lysine/RNA-interactions drive and regulate biomolecular condensation

(2019) Tina Ukmar-Godec et al.   Nature Communications

A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

(2019) Jian Kang et al.   PLOS BIOLOGY

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Dynamic Principle for Designing Antagonistic/Agonistic Molecules for EphA4 Receptor, the Only Known ALS Modifier

(2014) Haina Qin et al.   ACS Chemical Biology

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

The SARS coronavirus nucleocapsid protein – Forms and functions

(2014) Chung-ke Chang et al.   ANTIVIRAL RESEARCH

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Dynamically-Driven Inactivation of the Catalytic Machinery of the SARS 3C-Like Protease by the N214A Mutation on the Extra Domain

(2011) Jiahai Shi et al.   PLoS Computational Biology

Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

(2008) Haina Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY