Tracking intra‐ and inter‐organelle signaling of mitochondria

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

(2019) Benjamin Gottschalk et al.   Nature Communications

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

(2018) Karen Schmitt et al.   Cell Metabolism

Electrophysiological characterization of a mitochondrial inner membrane chloride channel in rat brain

(2018) Christopher D. Drummond-Main et al.   FEBS LETTERS

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

(2018) Bartłomiej Augustynek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation

(2018) Maria Dafne Cardamone et al.   MOLECULAR CELL

Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore

(2018) Saranya NavaneethaKrishnan et al.   ONCOGENE

Intracellular Ca2+ release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum

(2018) Benjamin Gottschalk et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Farming the mitochondrial ancestor as a model of endosymbiotic establishment by natural selection

(2018) István Zachar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson’s models

(2018) Hanna Kim et al.   Cell Death & Disease

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

(2018) Giampaolo Morciano et al.   NEOPLASIA

Structure and mechanism of mitochondrial electron transport chain

(2018) Runyu Guo et al.   Biomedical Journal

Geometric instability catalyzes mitochondrial fission

(2018) Ehsan Irajizad et al.   MOLECULAR BIOLOGY OF THE CELL

Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging

(2018) Corina T. Madreiter-Sokolowski et al.   Redox Biology

A novel fluorescent reporter detects plastic remodeling of mitochondria–ER contact sites

(2017) Zhaoying Yang et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges

(2017) Manuela Lavorato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

(2017) Helmut Bischof et al.   Nature Communications

Optogenetic Control of Endoplasmic Reticulum–Mitochondria Tethering

(2017) Fan Shi et al.   ACS Synthetic Biology

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca 2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

(2017) Melanie Paillard et al.   Cell Reports

LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux

(2017) Shane Austin et al.   Frontiers in Physiology

A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria

(2017) Mark Harmon et al.   Scientific Reports

What do we not know about mitochondrial potassium channels?

(2016) Michał Laskowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Physiology of intracellular potassium channels: A unifying role as mediators of counterion fluxes?

(2016) Vanessa Checchetto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial potassium homeostasis: a central player in cardioprotection

(2016) Rainer Schulz et al.   CARDIOVASCULAR RESEARCH

The MICOS complex of human mitochondria

(2016) Vera Kozjak-Pavlovic   CELL AND TISSUE RESEARCH

Intracellular Ca 2+ signaling and Ca 2+ microdomains in the control of cell survival, apoptosis and autophagy

(2016) Rita M.L. La Rovere et al.   CELL CALCIUM

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Ground control to major TOM: mitochondria-nucleus communication

(2016) Michal Eisenberg-Bord et al.   FEBS Journal

OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation

(2016) Miguel Barrera et al.   FEBS LETTERS

STED super-resolution imaging of mitochondria labeled with TMRM in living cells

(2016) Masaya Ishigaki et al.   MITOCHONDRION

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

Architecture of the mitochondrial calcium uniporter

(2016) Kirill Oxenoid et al.   NATURE

Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria

(2016) Alexander W. Mühleip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

(2016) Corina T. Madreiter-Sokolowski et al.   Nature Communications

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

(2016) Christina Glytsou et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation

(2016) Max E Harner et al.   eLife

Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells

(2016) Emily Tubbs et al.   Jove-Journal of Visualized Experiments

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

A Highly Selective Mitochondria-Targeting Fluorescent K+Sensor

(2015) Xiangxing Kong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

(2015) Weilin Wang et al.   CANCER LETTERS

Dynamic tubulation of mitochondria drives mitochondrial network formation

(2015) Chong Wang et al.   CELL RESEARCH

A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division

(2015) Kohei Arasaki et al.   DEVELOPMENTAL CELL

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

(2015) Natalia Stepanyants et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis

(2015) Aswin Pyakurel et al.   MOLECULAR CELL

Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange

(2015) Yidan Ding et al.   NATURE METHODS

Activation of large-conductance Ca2+-activated K+ channels inhibits glutamate-induced oxidative stress through attenuating ER stress and mitochondrial dysfunction

(2015) Xiao-Hua Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor

(2015) Yuncong Chen et al.   Chemical Science

Trans-mitochondrial coordination of cristae at regulated membrane junctions

(2015) Martin Picard et al.   Nature Communications

Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton

(2015) Valerii M. Sukhorukov et al.   Scientific Reports

Mitochondrial BKCa channel

(2015) Enrique Balderas et al.   Frontiers in Physiology

Mitochondrial membrane potential and reactive oxygen species in cancer stem cells

(2014) Bei-bei Zhang et al.   Familial Cancer

Mitochondrial biosensors

(2014) Roberto De Michele et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State

(2014) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Mitochondria-Immobilized pH-Sensitive Off–On Fluorescent Probe

(2014) Min Hee Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of localpHon the formation and regulation of cristae morphologies

(2014) Dong Hoon Song et al.   PHYSICAL REVIEW E

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice

(2014) Fotis Ioakeimidis et al.   PLoS One

A Novel Optical Intracellular Imaging Approach for Potassium Dynamics in Astrocytes

(2014) Theresa S. Rimmele et al.   PLoS One

Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria

(2014) Enrico Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral pH gradient between OXPHOS complex IV and F0F1 ATP-synthase in folded mitochondrial membranes

(2014) Bettina Rieger et al.   Nature Communications

Improved Orange and Red Ca2+ Indicators and Photophysical Considerations for Optogenetic Applications

(2013) Jiahui Wu et al.   ACS Chemical Neuroscience

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

(2013) Vassilios N. Kotiadis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Autophagy as a defence against intracellular pathogens

(2013) Tom Wileman   Essays in Biochemistry

Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling

(2013) E. M. Lynes et al.   JOURNAL OF CELL SCIENCE

Inner membrane dynamics in mitochondria

(2013) Daniel Dikov et al.   JOURNAL OF STRUCTURAL BIOLOGY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

ATP increases within the lumen of the endoplasmic reticulum upon intracellular Ca2+ release

(2013) Neelanjan Vishnu et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Signaling: Forwards, Backwards, and In Between

(2013) Sean P. Whelan et al.   Oxidative Medicine and Cellular Longevity

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain

(2013) Piotr Bednarczyk et al.   PLoS One

mitoBKCa is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location

(2013) H. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria

(2013) D. C. Jans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kissing and nanotunneling mediate intermitochondrial communication in the heart

(2013) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Mitochondrial Biogenesis through Activation of Nuclear Signaling Proteins

(2013) J. E. Dominy et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial NHE1: a newly identified target to prevent heart disease

(2013) Bernardo V. Alvarez et al.   Frontiers in Physiology

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

The renaissance of mitochondrial pH

(2012) Jaime Santo-Domingo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging

(2012) Martin P. Horan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

(2012) Maria Bohnert et al.   MOLECULAR BIOLOGY OF THE CELL

The Parkinson's disease-related genes act in mitochondrial homeostasis

(2012) Yan Sai et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Spatiotemporal Correlations between Cytosolic and Mitochondrial Ca2+ Signals Using a Novel Red-Shifted Mitochondrial Targeted Cameleon

(2012) Markus Waldeck-Weiermair et al.   PLoS One

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry

(2012) A Perelman et al.   Cell Death & Disease

Dimerization-Dependent Green and Yellow Fluorescent Proteins

(2012) Spencer C. Alford et al.   ACS Synthetic Biology

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Glibenclamide ameliorates ischemia–reperfusion injury via modulating oxidative stress and inflammatory mediators in the rat hippocampus

(2011) Dalaal M. Abdallah et al.   BRAIN RESEARCH

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Activation of the Permeability Transition Pore by Bax via Inhibition of the Mitochondrial BK Channel

(2011) Yu Cheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis

(2011) Karina von der Malsburg et al.   DEVELOPMENTAL CELL

The mitochondrial contact site complex, a determinant of mitochondrial architecture

(2011) Max Harner et al.   EMBO JOURNAL

Leucine Zipper EF Hand-containing Transmembrane Protein 1 (Letm1) and Uncoupling Proteins 2 and 3 (UCP2/3) Contribute to Two Distinct Mitochondrial Ca2+Uptake Pathways

(2011) Markus Waldeck-Weiermair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations

(2011) Damon Poburko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

(2011) Zhongyan Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Super-resolution 3D microscopy of live whole cells using structured illumination

(2011) Lin Shao et al.   NATURE METHODS

The Effect of OPA1 on Mitochondrial Ca2+ Signaling

(2011) László Fülöp et al.   PLoS One

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

An Expanded Palette of Genetically Encoded Ca2+ Indicators

(2011) Y. Zhao et al.   SCIENCE

Mitochondrial chloride channels - What are they for?

(2010) Zuzana Tomaskova et al.   FEBS LETTERS

Mitochondrial potassium channels and reactive oxygen species

(2010) Dominika Malinska et al.   FEBS LETTERS

Rab32 Modulates Apoptosis Onset and Mitochondria-associated Membrane (MAM) Properties

(2010) Michael Bui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters

(2010) F. T. Kurz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells

(2009) Elinor J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transport of proteins across or into the mitochondrial outer membrane

(2009) Toshiya Endo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial potassium channels

(2009) Adam Szewczyk et al.   IUBMB LIFE

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: The role of Ras

(2009) Olga Martins de Brito et al.   MITOCHONDRION

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

Membrane Deformation under Local pH Gradient: Mimicking Mitochondrial Cristae Dynamics

(2008) Nada Khalifat et al.   BIOPHYSICAL JOURNAL

Ca2+ Signaling, Mitochondria and Cell Death

(2008) Paolo Pinton et al.   CURRENT MOLECULAR MEDICINE

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

BK channel openers inhibit ROS production of isolated rat brain mitochondria

(2008) Bogusz Kulawiak et al.   EXPERIMENTAL NEUROLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Subdiffraction-resolution fluorescence imaging of proteins in the mitochondrial inner membrane with photoswitchable fluorophores

(2008) Sebastian van de Linde et al.   JOURNAL OF STRUCTURAL BIOLOGY

Chemical calcium indicators

(2008) R. Madelaine Paredes et al.   METHODS

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle

(2007) S. Chalmers et al.   JOURNAL OF CELL SCIENCE