The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria

(2020) Kentaro Ozawa et al.   Scientific Reports

Role of DJ-1 in Immune and Inflammatory Diseases

(2020) Lulu Zhang et al.   Frontiers in Immunology

Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease

(2020) Amit Sharma et al.   Redox Biology

Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme

(2020) Pauline Mencke et al.   Frontiers in Neurology

DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress

(2019) Jungwoo Yang et al.   Cell Death & Disease

The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β

(2019) Maria Weinert et al.   FASEB JOURNAL

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

(2019) Ludmila P. Dolgacheva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis

(2019) Brintha Selvarajah et al.   Science Signaling

Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

(2019) Rongmin Chen et al.   Cell Death & Disease

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients

(2019) Tommaso Nuzzo et al.   Scientific Reports

The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals

(2019) Anna Andreeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients

(2019) Sarah Louise Nickels et al.   PARKINSONISM & RELATED DISORDERS

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

(2019) Yi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

(2019) Katalin Solti et al.   NEUROBIOLOGY OF DISEASE

Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL

(2018) Gilbert Richarme et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson’s disease

(2018) MatthewE Gegg et al.   Neural Regeneration Research

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

(2018) Jyotiska Chaudhuri et al.   Cell Metabolism

DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

(2018) Jing Zhou et al.   Cell Death & Disease

DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis

(2017) Dominik Piston et al.   HUMAN MOLECULAR GENETICS

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

DJ-1 as a deglycating enzyme: A unique function to explain a multifaceted protein?

(2017) Marco Bisaglia et al.   Neural Regeneration Research

Reactive oxygen species-driven HIF1α triggers accelerated glycolysis in endothelial cells exposed to low oxygen tension

(2017) Jin-Young Paik et al.   NUCLEAR MEDICINE AND BIOLOGY

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling

(2017) Ramy H. Malty et al.   Cell Systems

Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro

(2017) Noriyuki Matsuda et al.   Scientific Reports

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology

(2016) Ricardo Taipa et al.   BRAIN

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification

(2016) Daniel H. Pfaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

(2016) J. Meiser et al.   NEUROBIOLOGY OF DISEASE

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

(2015) Dania C. Liemburg-Apers et al.   ARCHIVES OF TOXICOLOGY

DJ-1 as a human oncogene and potential therapeutic target

(2015) Ji Cao et al.   BIOCHEMICAL PHARMACOLOGY

Common Mechanisms of Onset of Cancer and Neurodegenerative Diseases

(2015) Hiroyoshi Ariga   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease

(2015) Karl Kieburtz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process

(2015) Chai-jui Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI Family Member Protein, Is Critical for Oxidative Stress Resistance inSaccharomyces cerevisiae

(2015) Kondalarao Bankapalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature

(2015) Nicole M. Milkovic et al.   PROTEIN SCIENCE

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe

(2014) Qiaoqiao Zhao et al.   BMC EVOLUTIONARY BIOLOGY

A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation

(2014) Tito Calì et al.   HUMAN MOLECULAR GENETICS

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

(2014) Gilbert Richarme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the VHL/HIF-1 Pathway by DJ-1

(2014) M. Parsanejad et al.   JOURNAL OF NEUROSCIENCE

Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

(2014) Pei Zhang et al.   Oxidative Medicine and Cellular Longevity

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

(2014) L Zondler et al.   Cell Death & Disease

Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption

(2014) Pamela Lopert et al.   Redox Biology

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal inCandida albicans

(2013) Sahar Hasim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Function of DJ-1 in Parkinson’s Disease

(2013) Hiroyoshi Ariga et al.   Oxidative Medicine and Cellular Longevity

Shared dysregulated pathways lead to Parkinson's disease and diabetes

(2013) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

(2013) Ryan J. Mailloux et al.   Redox Biology

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

Parkinson’s disease-associated mutations in DJ-1 modulate its dimerization in living cells

(2012) Mariaelena Repici et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Parkinson’s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Recent Advances in α-Synuclein Functions, Advanced Glycation, and Toxicity: Implications for Parkinson’s Disease

(2012) Erika Guerrero et al.   MOLECULAR NEUROBIOLOGY

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

(2012) Emilie Giaime et al.   PLoS One

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

(2012) Deepak Jain et al.   Journal of Molecular Cell Biology

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress

(2011) Melissa K. McCoy et al.   Autophagy

D-serine adjuvant treatment alleviates behavioural and motor symptoms in Parkinson's disease

(2011) Evgenia Gelfin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Hsp31 of Escherichia coli K-12 is glyoxalase III

(2011) Krishna P. Subedi et al.   MOLECULAR MICROBIOLOGY

The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction

(2010) Mark A. Wilson   ANTIOXIDANTS & REDOX SIGNALING

Keap1-Nrf2 activation in the presence and absence of DJ-1

(2010) Li Gan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal growth factor receptor amplification

(2010) David A. Hinkle et al.   NEUROPATHOLOGY

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

DJ-1 Loss by Glutaredoxin but Not Glutathione Depletion Triggers Daxx Translocation and Cell Death

(2009) Uzma Saeed et al.   ANTIOXIDANTS & REDOX SIGNALING

Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease

(2009) Alberto Ascherio   ARCHIVES OF NEUROLOGY

Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1

(2009) Jens Waak et al.   FASEB JOURNAL

The description of all four cardinal signs of Parkinson's disease in a Hungarian medical text published in 1690

(2009) Dániel Bereczki   PARKINSONISM & RELATED DISORDERS

Serum Urate as a Predictor of Clinical and Radiographic Progression in Parkinson Disease

(2008) Michael A. Schwarzschild   ARCHIVES OF NEUROLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

(2008) Eunsung Junn et al.   JOURNAL OF NEUROSCIENCE RESEARCH