Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability

The harsh microenvironment in early breast cancer selects for a Warburg phenotype

(2021) Mehdi Damaghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality control of the mitochondrion

(2021) Matthew Yoke Wui Ng et al.   DEVELOPMENTAL CELL

A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression

(2021) Ekta Agarwal et al.   Science Advances

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Mitochondrial Metabolism as a Target for Cancer Therapy

(2020) Karthik Vasan et al.   Cell Metabolism

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

(2020) Jie Li et al.   Science Signaling

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Context-dependent EMT programs in cancer metastasis

(2019) Nicole M. Aiello et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

(2019) Roheena Z. Panni et al.   Science Translational Medicine

Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer

(2019) Timothy J Humpton et al.   Cancer Discovery

Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits

(2019) Jagadish C. Ghosh et al.   ONCOGENE

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria in cancer metabolism, an organelle whose time has come?

(2018) Rebecca G. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice

(2018) Ya-Jie Lv et al.   Theranostics

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dynamics and metastasis

(2018) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

(2018) James M. McFarland et al.   Nature Communications

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer

(2017) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure

(2017) Pei-I Tsai et al.   MOLECULAR BIOLOGY OF THE CELL

Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division

(2017) Bongki Cho et al.   Nature Communications

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

(2017) Abdul S. Qadir et al.   Cell Reports

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

(2016) Shiori Akabane et al.   MOLECULAR CELL

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

The Cancer Diaspora: Metastasis beyond the Seed and Soil Hypothesis

(2013) K. J. Pienta et al.   CLINICAL CANCER RESEARCH

Mitofilin complexes: conserved organizers of mitochondrial membrane architecture

(2012) Ralf M. Zerbes et al.   BIOLOGICAL CHEMISTRY

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

(2012) Maria Bohnert et al.   MOLECULAR BIOLOGY OF THE CELL

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Redox regulation of cell migration and adhesion

(2012) Thomas Ryan Hurd et al.   TRENDS IN CELL BIOLOGY

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition

(2011) J. Hu et al.   BLOOD

Alterations in the Mitochondrial Proteome of Neuroblastoma Cells in Response to Complex 1 Inhibition

(2011) Florence Burté et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE