Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity

A detailed characterization of stepwise activation of the androgen receptor variant 7 in prostate cancer cells

(2021) Carlos M. Roggero et al.   ONCOGENE

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

(2021) Ryan W. Tibble et al.   Nature Chemical Biology

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

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Advances in histone demethylase KDM4 as cancer therapeutic targets

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A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

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Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

(2019) Albert Escobedo et al.   Nature Communications

Androgen receptor splicing variant 7: Beyond being a constitutively active variant

(2019) Chen Shao et al.   LIFE SCIENCES

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

(2018) Thomas R. Peskett et al.   MOLECULAR CELL

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators

(2018) Eva De Mol et al.   STRUCTURE

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

(2018) Jill J. Bouchard et al.   MOLECULAR CELL

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain

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Biomolecular condensates: organizers of cellular biochemistry

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Inhibition of androgen receptor by decoy molecules delays progression to castration-recurrent prostate cancer

(2017) Jae-Kyung Myung et al.   PLoS One

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

(2016) Eva De Mol et al.   ACS Chemical Biology

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

(2016) Bahareh Eftekharzadeh et al.   BIOPHYSICAL JOURNAL

Emerging data on androgen receptor splice variants in prostate cancer

(2016) Subing Cao et al.   ENDOCRINE-RELATED CANCER

Androgen receptor: structure, role in prostate cancer and drug discovery

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Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures

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Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Enlightening molecular mechanisms through study of protein interactions

(2012) Josep Rizo et al.   Journal of Molecular Cell Biology

Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy

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Intrinsic disorder in the androgen receptor: identification, characterisation and drugability

(2011) Iain J. McEwan   Molecular BioSystems

Cancer Statistics, 2010

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The epigenome as a therapeutic target in prostate cancer

(2010) Antoinette S. Perry et al.   Nature Reviews Urology

Steroid Hormone Receptors in Prostate Cancer: A Hard Habit to Break?

(2009) Gerhardt Attard et al.   CANCER CELL

Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

(2009) William P Harris et al.   Nature clinical practice. Urology

Structural Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies Structural Plasticity and Protein-Induced Folding†

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Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

(2008) Philippa Davies et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY