Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma

Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

(2021) Man Yu et al.   MOLECULAR CELL

Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction

(2021) Federico Giulitti et al.   Frontiers in Cell and Developmental Biology

Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis

(2021) Yaru Guo et al.   Bioactive Materials

Lipid droplets: platforms with multiple functions in cancer hallmarks

(2020) André L. S. Cruz et al.   Cell Death & Disease

Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice

(2020) Wei Fu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Dihydroartemisinin, an antimalarial drug, induces absent in melanoma 2 inflammasome activation and autophagy in human hepatocellular carcinoma HepG2215 cells

(2019) Xinli Shi et al.   PHYTOTHERAPY RESEARCH

Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer

(2019) Quanfu Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC

(2019) Berndt et al.   Cells

The significance of lipid accumulation in breast carcinoma cells through perilipin 2 and its clinicopathological significance

(2019) Shimpei Kuniyoshi et al.   PATHOLOGY INTERNATIONAL

Artemisinin suppresses hepatocellular carcinoma cell growth, migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling

(2019) Yujie Li et al.   ARCHIVES OF TOXICOLOGY

PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism

(2019) Yanjie Tan et al.   BMC MOLECULAR BIOLOGY

High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis

(2018) Ruochan Chen et al.   HEPATOLOGY

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

(2018) Alexia Karen Cotte et al.   Nature Communications

Association of tamoxifen resistance and lipid reprogramming in breast cancer

(2018) Susanne Hultsch et al.   BMC CANCER

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

(2018) Toni Petan et al.   MOLECULES

Antimalarial Dihydroartemisinin Triggers Autophagy within HeLa Cells of Human Cervical Cancer through Bcl-2 Phosphorylation at Ser70

(2018) Li Wang et al.   PHYTOMEDICINE

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

(2017) Sachin H. Patel et al.   GASTROENTEROLOGY

PD-L1

(2017) Anthousa Kythreotou et al.   JOURNAL OF CLINICAL PATHOLOGY

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

(2017) Weinan Du et al.   Nature Communications

Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

(2017) Xinli Shi et al.   Oncotarget

Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6

(2016) Harrison Penrose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Artesunate inhibits adipogeneis in 3T3-L1 preadipocytes by reducing the expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3

(2016) Byeong-Churl Jang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

(2016) Juri Bergmann et al.   HEPATOLOGY

Targeting T Cell Co-receptors for Cancer Therapy

(2016) Margaret K. Callahan et al.   IMMUNITY

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants

(2016) Lei Yang et al.   Science Bulletin

Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

(2015) T. Shpilka et al.   EMBO JOURNAL

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

(2015) Edna Ooko et al.   PHYTOMEDICINE

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

HIF2 -Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

(2015) B. Qiu et al.   Cancer Discovery

YAP activation is an early event and a potential therapeutic target in liver cancer development

(2014) Andrea Perra et al.   JOURNAL OF HEPATOLOGY

Perilipins: Lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection

(2013) Carole Sztalryd et al.   BIOCHIMIE

Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease

(2013) James L. McManaman et al.   JOURNAL OF LIPID RESEARCH

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets

(2011) Sophie Clément et al.   HEPATOLOGY

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

(2008) J. Hou et al.   CLINICAL CANCER RESEARCH