Dihydroartemisinin, an antimalarial drug, induces absent in melanoma 2 inflammasome activation and autophagy in human hepatocellular carcinoma HepG2215 cells

IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation

(2018) Xiuqing Pang et al.   BMC GASTROENTEROLOGY

AIM2 is a potential therapeutic target in human renal carcinoma and suppresses its invasion and metastasis via enhancing autophagy induction

(2018) Dafei Chai et al.   EXPERIMENTAL CELL RESEARCH

Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

(2018) Fengjiao Wang et al.   International Journal of Biological Sciences

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

(2018) Monica L. Gonzalez Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

(2018) Nathalia Pizato et al.   Scientific Reports

Differential Activation of NLRP3, AIM2, and IFI16 Inflammasomes in Humans with Acute and Chronic Hepatitis B

(2018) Hongtao Chen et al.   VIRAL IMMUNOLOGY

Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway

(2017) Wen-Dong Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis

(2017) Shi-Lu Chen et al.   Molecular Oncology

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Infection and Cancer: The Case of Hepatitis B

(2016) Stephen L. Chan et al.   JOURNAL OF CLINICAL ONCOLOGY

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants

(2016) Lei Yang et al.   Science Bulletin

Artemisinin anti-malarial drugs in China

(2016) Zongru Guo   Acta Pharmaceutica Sinica B

Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

(2016) Lifeng Jia et al.   PLoS One

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity

(2015) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Anti-Cancer Drugs Reactivate Tumor Suppressor miR-375 Expression in Tongue Cancer Cells

(2015) Hyun Min Jung et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activation

(2014) Xin-li Shi et al.   ACTA PHARMACOLOGICA SINICA

IFI16 mis-localization can be a contributing factor to hepatocellular carcinoma progression

(2014) Xinli Shi et al.   MEDICAL HYPOTHESES

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells

(2013) Yoshinobu Odaka et al.   CARCINOGENESIS

Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B

(2013) Dian-Lei Wu et al.   HUMAN IMMUNOLOGY

Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression

(2013) Qing Wei et al.   LABORATORY INVESTIGATION

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Sensing the Dark Side of DNA

(2013) L. A. J. O'Neill   SCIENCE

From Cirrhosis to Hepatocellular Carcinoma: New Molecular Insights on Inflammation and Cellular Senescence

(2013) Gayatri Ramakrishna et al.   Liver Cancer

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

(2011) Sudhakar Veeranki et al.   PLoS One

Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells

(2011) Xueting Cai et al.   TOXICOLOGY IN VITRO

Cytosolic DNA sensors regulating type I interferon induction

(2011) Sinead E. Keating et al.   TRENDS IN IMMUNOLOGY

γH2AX as a molecular marker of aging and disease

(2010) Li-Jeen Mah et al.   Epigenetics

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus

(2010) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma

(2010) Feng Yu et al.   LIVER INTERNATIONAL

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

The innate immune response to DNA

(2009) Akosua Vilaysane et al.   SEMINARS IN IMMUNOLOGY

Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma

(2008) Z.-B. Ding et al.   CANCER RESEARCH