Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors

(2018) Philippe Marchetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

(2018) Azhar Ali et al.   EMBO Molecular Medicine

17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression

(2018) Quanfu Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells

(2018) Barbara Lettiero et al.   Scientific Reports

Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR

(2018) Jun Guo et al.   FEBS LETTERS

Omental adipocytes enhance the invasiveness of gastric cancer cells by oleic acid-induced activation of the PI3K-Akt signaling pathway

(2017) Fan Xiang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

(2017) Jiqin Zhang et al.   Molecular Cancer

The Perilipins: Major Cytosolic Lipid Droplet–Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis

(2016) Alan R. Kimmel et al.   Annual Review of Nutrition

Adipophilin expression in lung adenocarcinoma is associated with apocrine-like features and poor clinical prognosis: an immunohistochemical study of 328 cases

(2016) Masakazu Fujimoto et al.   HISTOPATHOLOGY

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

(2016) Aaron N Hata et al.   NATURE MEDICINE

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids

(2015) A. D. Southam et al.   CANCER RESEARCH

Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer

(2015) V. De Rosa et al.   CLINICAL CANCER RESEARCH

Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors

(2015) Michael Juchum et al.   DRUG RESISTANCE UPDATES

20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes

(2015) Gyun-Sik Oh et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

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Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma

(2014) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

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High Metastaticgastric and Breast Cancer Cells Consume Oleic Acid in an AMPK Dependent Manner

(2014) Shuai Li et al.   PLoS One

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice

(2014) Yu Zhang et al.   Scientific Reports

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer: A new era begins

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Impact of EGFR Inhibitor in Non–Small Cell Lung Cancer on Progression-Free and Overall Survival: A Meta-Analysis

(2013) Chee Khoon Lee et al.   JNCI-Journal of the National Cancer Institute

Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells

(2013) A Noto et al.   Cell Death & Disease

Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes

(2012) Yuji Komizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Targeting Cancer Metabolism

(2012) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Membrane physical properties influence transmembrane helix formation

(2012) F. N. Barrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Plasma Metabolomics and Lipid Profiling

(2011) A. D. Patterson et al.   CANCER RESEARCH

A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases

(2010) Heather A. Hirsch et al.   CANCER CELL

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Adenocarcinoma

(2010) K. Kasahara et al.   CLINICAL CANCER RESEARCH

Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations

(2010) Jenn-Yu Wu et al.   LUNG CANCER

Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells

(2009) Kar Wah Leung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT