TLR4 biased small molecule modulators

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

(2021) Qing-Tao He et al.   Nature Communications

Small-Molecule Modulators of Toll-like Receptors

(2020) Yibo Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dissociation of TRIF bias and adjuvanticity

(2020) Katharina Richard et al.   VACCINE

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe

(2020) Qi Liu et al.   Nature Communications

Below the surface: The inner lives of TLR4 and TLR9

(2019) Laura Marongiu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell

(2019) Xiaohui Wang et al.   ACS Chemical Neuroscience

Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking

(2018) Kyle T. Brown et al.   BRAIN BEHAVIOR AND IMMUNITY

TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia

(2018) Kevin G. Burfeind et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders

(2018) Denise K. Patten et al.   PHARMACOTHERAPY

New Insights into Modes of GPCR Activation

(2018) Wenjing Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

(2017) Chun-Hua Liu et al.   Nature Communications

Biased signalling is an essential feature of TLR4 in glioma cells

(2016) Marie-Theres Zeuner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4

(2016) X Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type–Specific Manner

(2016) Megumi Tatematsu et al.   JOURNAL OF IMMUNOLOGY

MPLA shows attenuated pro-inflammatory properties and diminished capacity to activate mast cells in comparison with LPS

(2015) S. Schülke et al.   ALLERGY

DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

(2015) A L Northcutt et al.   MOLECULAR PSYCHIATRY

MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4

(2015) Alja Oblak et al.   PLoS One

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

(2014) Jarred Younger et al.   CLINICAL RHEUMATOLOGY

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Biased Agonism at G Protein-Coupled Receptors: The Promise and the Challenges-A Medicinal Chemistry Perspective

(2014) Jeremy Shonberg et al.   MEDICINAL RESEARCH REVIEWS

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy

(2012) Kevin J. Frankowski et al.   ACS Chemical Neuroscience

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

(2012) W. S. Bowen et al.   Science Signaling

Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway

(2012) Shu-Husan Chou et al.   SYNAPSE

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders

(2011) Sun Hong Park et al.   PHARMACOLOGY & THERAPEUTICS

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 and Type I Interferon Receptor-Mediated Chemokine Induction and Monocyte Recruitment during Listeria monocytogenes Infection

(2009) T. Jia et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF- B Activation

(2008) D. B. Conze et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

IRAK1: A critical signaling mediator of innate immunity

(2007) Sridevi Gottipati et al.   CELLULAR SIGNALLING