Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

(2015) A L Northcutt et al.   MOLECULAR PSYCHIATRY

TRIF and IRF-3 Binding to the TNF Promoter Results in Macrophage TNF Dysregulation and Steatosis Induced by Chronic Ethanol

(2014) X.-J. Zhao et al.   JOURNAL OF IMMUNOLOGY

PTX3 Binds MD-2 and Promotes TRIF-Dependent Immune Protection in Aspergillosis

(2014) Silvia Bozza et al.   JOURNAL OF IMMUNOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

(2014) K.-H. Tse et al.   NEUROSCIENCE

In vivo veritas: (+)-Naltrexone's actions define translational importance

(2014) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving

(2013) Florence R. Theberge et al.   BIOLOGICAL PSYCHIATRY

Targeting Toll-like receptors with small molecule agents

(2013) Xiaohui Wang et al.   CHEMICAL SOCIETY REVIEWS

Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain

(2013) Xiaohui Wang et al.   FASEB JOURNAL

Brain microglia: watchdogs with pedigree

(2013) Harald Neumann et al.   NATURE NEUROSCIENCE

Why is neuroimmunopharmacology crucial for the future of addiction research?

(2013) Mark R. Hutchinson et al.   NEUROPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Reactive oxygen species contribute to neuropathic pain and locomotor dysfunction via activation of CamKII in remote segments following spinal cord contusion injury in rats

(2013) Young S. Gwak et al.   PAIN

Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4

(2012) CW Stevens et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting Interleukin-1β for Pain

(2012) Sivaram Pillarisetti   CNS & Neurological Disorders-Drug Targets

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91 phox subunit of NADPH oxidase

(2012) Qingshan Wang et al.   Journal of Neuroinflammation

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

(+)-Naloxone, an Opioid-Inactive Toll-Like Receptor 4 Signaling Inhibitor, Reverses Multiple Models of Chronic Neuropathic Pain in Rats

(2012) Susannah S. Lewis et al.   JOURNAL OF PAIN

Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence

(2012) Janet K. Coller et al.   PHARMACOLOGY & THERAPEUTICS

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

(2012) Lisa C. Loram et al.   PSYCHONEUROENDOCRINOLOGY

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

(2012) W. S. Bowen et al.   Science Signaling

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release

(2011) June Yowtak et al.   PAIN

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein–protein interactions

(2010) Catherine Joce et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

TNF-α and neuropathic pain - a review

(2010) Lawrence Leung et al.   Journal of Neuroinflammation

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4

(2010) Douglas E. Bevan et al.   ACS Medicinal Chemistry Letters

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor–Gs Coupling and CREB Activation of Acute Morphine

(2009) Hoau-Yan Wang et al.   PLoS One

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing

(2009) Achim Schmidtko et al.   TRENDS IN NEUROSCIENCES

Modulation of Opioid Actions by Nitric Oxide Signaling

(2008) Noboru Toda et al.   ANESTHESIOLOGY

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

(2008) Ryan N. Dilger et al.   JOURNAL OF LEUKOCYTE BIOLOGY