Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-κB Suppression and NLRP3 Inflammasome Inhibition

Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis

(2021) Yaling Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

(2021) Lalita Subedi et al.   ACS Chemical Neuroscience

Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk

(2020) Amita Daverey et al.   JOURNAL OF NEUROTRAUMA

Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury

(2020) Maryna Baydyuk et al.   NEUROCHEMICAL RESEARCH

Translating concepts of neural repair after stroke: Structural and functional targets for recovery

(2020) Robert W. Regenhardt et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Curcumin: an inflammasome silencer

(2020) Shima Hassanzadeh et al.   PHARMACOLOGICAL RESEARCH

The combination of Panax ginseng and Angelica sinensis alleviates ischemia brain injury by suppressing NLRP3 inflammasome activation and microglial pyroptosis

(2020) Jia Hu et al.   PHYTOMEDICINE

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage

(2020) Pengfei Xu et al.   Translational Stroke Research

Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway

(2020) Kankai Wang et al.   Frontiers in Neuroscience

Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems

(2020) Naoki Abe et al.   Cells

Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner

(2020) Wei Yu et al.   Cardiovascular Diagnosis and Therapy

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

(2020) Maximilian Franke et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting pyroptosis to regulate ischemic stroke injury: Molecular mechanisms and preclinical evidences

(2020) Anqi Ye et al.   BRAIN RESEARCH BULLETIN

Mutant erythropoietin enhances white matter repair via the JAK2/STAT3 and C/EBPβ pathway in middle-aged mice following cerebral ischemia and reperfusion

(2020) Rongliang Wang et al.   EXPERIMENTAL NEUROLOGY

Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination

(2020) Jiayin Zheng et al.   EXPERIMENTAL NEUROLOGY

Nano-curcumin simultaneously protects the blood-brain barrier and reduces M1-microglial activation during cerebral ischemia-reperfusion injury

(2019) Ye Wang et al.   ACS Applied Materials & Interfaces

LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke

(2019) Xi Zhang et al.   Journal of Neuroinflammation

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

(2019) Pengfei Xu et al.   Cell Death & Disease

Nano-formulated curcumin (Lipodisq™) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats

(2019) Petr Krupa et al.   NEUROPHARMACOLOGY

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

(2019) Eridan Rocha-Ferreira et al.   Frontiers in Physiology

Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway

(2019) Zong‐Jian Liu et al.   CNS Neuroscience & Therapeutics

Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?

(2019) Laura Reiche et al.   Cells

Long-term effects of curcumin in the non-human primate brain

(2018) Bang-Bon Koo et al.   BRAIN RESEARCH BULLETIN

Mechanisms of demyelination and remyelination in the young and aged brain following white matter stroke

(2018) Miguel Alejandro Marin et al.   NEUROBIOLOGY OF DISEASE

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research

(2018) Li-Ru Zhao et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke

(2018) Cai-Jun Xie et al.   Brain and Behavior

Selective role of Na+ /H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post-stroke function recovery

(2018) Shanshan Song et al.   GLIA

Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling

(2018) Xiong Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Curcumin inhibits endoplasmic reticulum stress induced by cerebral ischemia‑reperfusion injury in rats

(2017) Haiying Zhu et al.   Experimental and Therapeutic Medicine

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

(2017) Zongjian Liu et al.   Frontiers in Aging Neuroscience

Curcumin protects against stroke and increases levels of Notch intracellular domain

(2016) Shuang Liu et al.   NEUROLOGICAL RESEARCH

White matter injury in ischemic stroke

(2016) Yuan Wang et al.   PROGRESS IN NEUROBIOLOGY

Gasdermins pore cell membrane to pyroptosis

(2016) Huanhuan Liang et al.   Science China-Life Sciences

Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages

(2016) Fanqi Kong et al.   Frontiers in Pharmacology

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Curcumin attenuates ischemia-like injury induced IL-1β elevation in brain microvascular endothelial cells via inhibiting MAPK pathways and nuclear factor-κB activation

(2014) Hua-jiang Dong et al.   NEUROLOGICAL SCIENCES

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Protecting White Matter From Stroke Injury

(2012) Carlos Matute et al.   STROKE

Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo

(2010) Liu-fang He et al.   BRAIN RESEARCH

Erythropoietin Amplifies Stroke-Induced Oligodendrogenesis in the Rat

(2010) Li Zhang et al.   PLoS One

Oligovascular Signaling in White Matter Stroke

(2009) Ken Arai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Evolution of Inflammation and White Matter Injury in a Model of Transient Focal Ischemia

(2009) Iska Moxon-Emre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY