Article
Neurosciences
Cui Liu, Song Han, Jiayin Zheng, Hongyu Wang, Shujuan Li, Junfa Li
Summary: Ischemic stroke leads to white matter injury and neurobehavioral dysfunction, and there is a lack of effective therapies to inhibit demyelination or promote remyelination. EphA4 promotes the proliferation of oligodendrocyte precursor cells but reduces the numbers of mature oligodendrocytes and the levels of myelin-associated proteins. EphA4 regulates white matter remyelination after ischemic stroke through the Ephexin-1/RhoA/ROCK signaling pathway. EphA4 may provide a novel therapeutic target in the clinical practice of ischemic stroke.
Article
Biochemistry & Molecular Biology
Qianqian Li, George Fadoul, Milos Ikonomovic, Tuo Yang, Feng Zhang
Summary: The activation of Nrf2 reduces neuronal loss, white matter injury, and neurobehavioral deficits in a mouse model of PSCI. The Nrf2 activator, sulforaphane, improved long-term sensorimotor and cognitive deficits after ischemic stroke in wildtype mice. This neuroprotective effect was dependent on Nrf2 activation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Lei Jiang, Li Cheng, Han Chen, Haibin Dai, Dadao An, Qianyi Ma, Yanrong Zheng, Xiangnan Zhang, Weiwei Hu, Zhong Chen
Summary: Neonatal hypoxic-ischemic encephalopathy often results in white matter injury, affecting lifelong cognitive function. The histamine H2 receptor negatively regulates oligodendrocyte differentiation and may serve as a therapeutic target for promoting remyelination. Antagonists of H2R show potential therapeutic value in improving outcomes associated with neonatal HIE.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Clinical Neurology
Laura Heitsch, Laura Ibanez, Caty Carrera, Michael M. Binkley, Daniel Strbian, Turgut Tatlisumak, Alejandro Bustamante, Marc Ribo, Carlos Molina, Antoni Davalos, Elena Lopez-Cancio, Lucia Munoz-Narbona, Carol Soriano-Tarraga, Eva Giralt-Steinhauer, Victor Obach, Agnieszka Slowik, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Tomas Sobrino, Jose Castillo, Francisco Campos, Emilio Rodriguez-Castro, Susana Arias-Rivas, Tomas Segura, Gemma Serrano-Heras, Cristofol Vives-Bauza, Rosa Diaz-Navarro, Silva Tur, Carmen Jimenez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Juan Arenillas, Jerzy Krupinski, Natalia Cullell, Nuria P. Torres-Aguila, Elena Muino, Jara Carcel-Marquez, Francisco Moniche, Juan A. Cabezas, Andria L. Ford, Rajat Dhar, Jaume Roquer, Pooja Khatri, Jordi Jimenez-Conde, Israel Fernandez-Cadenas, Joan Montaner, Jonathan Rosand, Carlos Cruchaga, Jin-Moo Lee
Summary: The study investigated the dynamic metric Delta NIHSS6-24h in acute ischemic stroke patients, finding significant associations with long-term outcomes. This metric could serve as a meaningful quantitative phenotype for large-scale genomic studies.
Article
Clinical Neurology
Mark R. Etherton, Ona Wu, Anne-Katrin Giese, Natalia S. Rost
Summary: In this study of 319 patients with acute ischemic stroke, it was found that normal-appearing white matter axial diffusivity increases with age and independently predicts white matter hyperintensity volume. Increasing age and admission diastolic blood pressure were also identified as independent predictors of normal-appearing white matter axial diffusivity.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Endocrinology & Metabolism
Longfei Wu, Di Wu, Jian Chen, Chunhua Chen, Tianqi Yao, Xiaoduo He, Yanqin Ma, Xinglong Zhi, Renyu Liu, Xunming Ji
Summary: Intranasal administration of SA reduced infarct volume, occupancy effect, and diffusion limitation in the lesion, leading to significantly improved neurological outcomes in a rhesus monkey ischemic stroke model over a 28-day observation period.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Sungmin Hong, Anne-Katrin Giese, Markus D. Schirmer, Anna K. Bonkhoff, Martin Bretzner, Pamela Rist, Adrian Dalca, Robert W. Regenhardt, Mark R. Etherton, Kathleen L. Donahue, Marco Nardin, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Jaume Roquer, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Christian Enzinger, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Ona Wu, Christina Jern, Arne G. Lindgren, Jane Maguire, Liisa Tomppo, Polina Golland, Natalia S. Rost
Summary: The excessive burden of unaccounted white matter hyperintensities (WMH) in post-stroke patients, not explained by traditional risk factors, is associated with poorer long-term functional outcomes. This suggests that white matter hyperintensities unrelated to conventional risk factors may play a crucial role in stroke recovery and serve as an indicator of brain health.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Shen Li, Jun-Hua Rao, Xiao-Yan Lan, Xu Li, Cheng-Yan Chu, Yajie Liang, Miroslaw Janowski, Hong-Tian Zhang, Piotr Walczak
Summary: The study in non-human primates with ischemic stroke induced by MCAO revealed white matter damage, immune cell infiltration, and highlighted that demyelination precedes axonal injury, providing an opportunity for stroke intervention focusing on myelin regeneration to prevent progressive axonal loss.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Mark R. Etherton, Markus D. Schirmer, Maria Clara Zanon Zotin, Pamela M. Rist, Gregoire Boulouis, Arne Lauer, Ona Wu, Natalia S. Rost
Summary: The study found that white matter hyperintensity volume, age, pre-stroke disability, and normal-appearing white matter mean diffusivity were independently associated with increased PSMD. Additionally, the effect of age on functional outcomes was indirectly mediated by PSMD. Increased PSMD could serve as a putative radiographic marker of brain age for stroke outcomes prognostication.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Ramon Iglesias-Rey, Andres da Silva-Candal, Manuel Rodriguez-Yanez, Ana Estany-Gestal, Uxia Regueiro, Elena Maqueda, Paulo Avila-Gomez, Jose Manuel Pumar, Jose Castillo, Tomas Sobrino, Francisco Campos, Pablo Hervella
Summary: The study found that neurological instability (NI) is associated with the prognosis of stroke patients, with negative NI having a higher correlation with poor outcomes. The presence of negative NI within 48 hours in stroke patients may indicate the presence of a cerebral penumbra. Patients with NI can be differentiated by glutamate and IL6 levels, reflecting different levels of cellular damage and inflammation.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Neurosciences
Wei Zhang, Sijie Li, Ho Jun Yun, Wantong Yu, Wenjie Shi, Chen Gao, Jun Xu, Yu Yang, Linhui Qin, Yuchuan Ding, Kunlin Jin, Fengyong Liu, Xunming Ji, Changhong Ren
Summary: This study finds that hypoxic postconditioning (HPC) can promote white matter repair after ischemic stroke (IS), and the polarization of microglia plays an important role in white matter repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Sven P. R. Luijten, Daniel Bos, Kars C. J. Compagne, Lennard Wolff, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Wim H. van Zwam, Robert J. van Oostenbrugge, Diederik W. J. Dippel, Aad van der Lugt, Adriaan C. G. M. van Es
Summary: The severity of white matter lesions is negatively associated with functional outcomes in patients with acute ischemic stroke, but does not modify the effect of endovascular treatment.
Article
Neurosciences
Liqiang Liu, Jia Liu, Ming Li, Junxuan Lyu, Wei Su, Shejun Feng, Xunming Ji
Summary: This study investigated the effects of mild selective brain hypothermia on aged female ischemic mice. The results showed that mild selective brain hypothermia protected the sensorimotor and cognitive functions of elderly female ischemic mice and reduced infarct volume and brain atrophy. In addition, hypothermia alleviated ischemia-induced white matter injury and promoted long-term functional recovery by suppressing harmful immune response.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Shuangfeng Huang, Changhong Ren, Yumin Luo, Yuchuan Ding, Xunming Ji, Sijie Li
Summary: Oligodendrocytes (OLs) play a crucial role in maintaining axonal integrity and function in the central nervous system. Damage to OLs caused by hypoxia-ischemia can lead to axonal dystrophy, neuronal dysfunction, and neurological impairments. Targeting OLs and their receptors through therapeutic strategies is essential for attenuating ischemia injury and promoting recovery after stroke. This review provides an overview of recent advances in understanding OLs' function in ischemic injury and discusses potential protective strategies against OLs deaths.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Imad Derraz, Mohamed Abdelrady, Raed Ahmed, Nicolas Gaillard, Riccardo Morganti, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Carlos Riquelme, Lucas Corti, Gregory Gascou, Isabelle Mourand, Caroline Arquizan, Vincent Costalat
Summary: This study aimed to assess whether the burden of white matter hyperintensity (WMH) is associated with an increased risk of symptomatic intracranial hemorrhage (sICH) or poor functional outcome in patients with acute ischemic stroke treated with endovascular thrombectomy (EVT). The results showed that a higher burden of WMH was associated with an increased risk of poor functional outcome at 3 months after EVT.
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
