Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones

Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3•, and CF3– Reactivity

(2021) Hao Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aryl Radical Activation of C–O Bonds: Copper-Catalyzed Deoxygenative Difluoromethylation of Alcohols

(2021) Aijie Cai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

(2021) Aijie Cai et al.   Nature Communications

Na 2 Eosin Y Catalyzed Alkylation of Enol Acetates by Radical Decarboxylation of N‐Hydroxyphthalimide Esters

(2021) Yu Nie et al.   Asian Journal of Organic Chemistry

Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (O-, S-, N-, P-, Se-) with Fluoroiodomethane

(2020) Raffaele Senatore et al.   ORGANIC LETTERS

Monofluoromethyl‐Substituted Sulfonium Ylides: Preparation, Structure‐Reactivity Study and Substrate Scope

(2020) Xin Hong et al.   CHINESE JOURNAL OF CHEMISTRY

C(sp3)-CF3 Reductive Elimination from a Five-Coordinate Neutral Copper(III) Complex

(2020) Shuanshuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative and Deaminative Alkylation of Difluoroenoxysilanes via Photoredox Catalysis: A General Method for Site-Selective Synthesis of Difluoroalkylated Alkanes

(2020) Heng Song et al.   ORGANIC LETTERS

Silver‐Enabled General Radical Difluoromethylation Reaction with TMSCF 2 H

(2020) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Promoted Synthesis of α-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates

(2020) Zengqiang Feng et al.   ORGANIC LETTERS

Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem -Difluoroalkenes

(2019) Haidong Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents

(2019) Jun-Liang Zeng et al.   ORGANIC LETTERS

Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes

(2019) Teng Ma et al.   ACS Catalysis

Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination

(2019) Jiakun Li et al.   Nature Chemistry

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent

(2019) Margherita Miele et al.   ORGANIC LETTERS

Nucleophilic (Phenylsulfonyl/arylthio)difluoromethylation of Aldehydes with TMSCF2Br: A Three-Component Strategy

(2019) Qiqiang Xie et al.   ORGANIC LETTERS

Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes

(2018) Liting Yu et al.   ORGANIC LETTERS

Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides

(2018) Zhang Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Visible Light-Mediated Trifluoromethylation of Fluorinated Alkenes via C−F Bond Cleavage

(2018) Liu-Hai Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Ni(0)-Catalyzed Three-Component Coupling Reaction of Tetrafluoroethylene and N-Sulfonyl-Substituted Imines with Silanes via Aza-Nickelacycles

(2018) Hiroshi Shirataki et al.   ORGANIC LETTERS

Visible-Light-Mediated Regioselective Chlorosulfonylation of Alkenes and Alkynes: Introducing the Cu(II) Complex [Cu(dap)Cl2] to Photochemical ATRA Reactions

(2018) Asik Hossain et al.   ACS Catalysis

Nickel-Catalyzed Formation of 1,3-Dienes via a Highly Selective Cross-Tetramerization of Tetrafluoroethylene, Styrenes, Alkynes, and Ethylene

(2017) Takuya Kawashima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes

(2017) Hironobu Sakaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides

(2017) Xi Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

(2017) Douglas L. Orsi et al.   ORGANIC LETTERS

Nickel-Catalyzed Hydroalkenylation of Alkynes through C–F Bond Activation: Synthesis of 2-Fluoro-1,3-dienes

(2017) Junji Ichikawa et al.   SYNTHESIS-STUTTGART

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Copper-Catalyzed Stereoselective Defluorinative Borylation and Silylation of gem -Difluoroalkenes

(2017) Dong-Hang Tan et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes

(2016) Richard T. Thornbury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sterically Controlled Cu-Catalyzed or Transition-Metal-Free Cross-Coupling of gem-Difluoroalkenes with Tertiary, Secondary, and Primary Alkyl Grignard Reagents

(2016) Wenpeng Dai et al.   ORGANIC LETTERS

Synthesis of β-Hydroxysulfones from Sulfonyl Chlorides and Alkenes Utilizing Visible Light Photocatalytic Sequences

(2016) Santosh K. Pagire et al.   ORGANIC LETTERS

Photoredox-Catalyzed Bromodifluoromethylation of Alkenes with (Difluoromethyl)triphenylphosphonium Bromide

(2016) Qing-Yu Lin et al.   ORGANIC LETTERS

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

(2015) Zhang Feng et al.   ORGANIC LETTERS

Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation

(2015) Panpan Tian et al.   Nature Communications

Selective difluoroalkylation of alkenes by using visible light photoredox catalysis

(2014) Chunghyeon Yu et al.   CHEMICAL COMMUNICATIONS

Nucleophilic, radical, and electrophilic (phenylsulfonyl)difluoromethylations

(2009) Jinbo Hu   JOURNAL OF FLUORINE CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS