Na2 Eosin Y Catalyzed Alkylation of Enol Acetates by Radical Decarboxylation of N-Hydroxyphthalimide Esters

A novel, efficient and transition-metal-free alkylation of enol acetates by radical decarboxylation of N-hydroxyphthalimide esters to synthesize alpha-alkylated ketones in existence of Na-2-eosin Y at room temperature has been developed. This methodology features operational simplicity, mild reaction conditions, widely functional group tolerance, affording a diverse array of alpha-alkylated ketones in moderate to good yields.

Automated summary

A novel method has been developed for the synthesis of alpha-alkylated ketones from enol acetates through radical decarboxylation of N-hydroxyphthalimide esters in the presence of Na-2-eosin Y at room temperature. This methodology is characterized by its operational simplicity, mild reaction conditions, and wide functional group tolerance, leading to the formation of a diverse array of alpha-alkylated ketones in moderate to good yields.