Journal
ORGANIC LETTERS
Volume 21, Issue 20, Pages 8261-8265Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03024
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- University of Vienna
- University of Messina
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The homologation of Weinreb amides into difluoromethylketones with a formal nucleophilic CHF2 transfer agent is reported. Activating TMSCHF2 with potassium tert-amylate enables a convenient access to the difluorinated homologation reagent, which adds to the acylating partners. The high chemoselectivity showcased in the presence of variously multifunctionalized Weinreb amides, jointly with uniformly high yields, enables the strategy of general applicability without requiring any stabilization element for the putative carbanion.
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