Recent developments in enantio- and diastereoselective hydrogenation of N-heteroaromatic compounds

Interrupted Pyridine Hydrogenation: Asymmetric Synthesis of δ‐Lactams

(2021) Tobias Wagener et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

U.S. FDA Approved Drugs from 2015–June 2020: A Perspective

(2021) Priyadeep Bhutani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ru‐TsDPEN catalysts and derivatives in asymmetric transfer hydrogenation reactions

(2021) Ashish A. Mishra et al.   CHIRALITY

Ru‐NHC‐Catalyzed Asymmetric Hydrogenation of 2‐Quinolones to Chiral 3,4‐Dihydro‐2‐Quinolones

(2021) Tianjiao Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Indolizidine Synthesis through the Ir-Catalyzed Asymmetric Hydrogenation of Cyclic Pyridinium Salts

(2021) Wenkuan Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Unveiling a key catalytic pocket for the ruthenium NHC-catalysed asymmetric heteroarene hydrogenation

(2021) Andrea Hamza et al.   Chemical Science

Coronavirus puts drug repurposing on the fast track

(2020) Charlotte Harrison   NATURE BIOTECHNOLOGY

Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines

(2020) Alexia N. Kim et al.   ACS Catalysis

Mechanistic Understanding of the Heterogeneous, Rhodium-Cyclic (Alkyl)(Amino)Carbene-Catalyzed (Fluoro-)Arene Hydrogenation

(2020) Daniel Moock et al.   ACS Catalysis

Asymmetric Ruthenium-Catalyzed Hydrogenation of Terpyridine-Type N-Heteroarenes: Direct Access to Chiral Tridentate Nitrogen Ligands

(2020) Chenghao Li et al.   ORGANIC LETTERS

Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation

(2020) Tobias Wagener et al.   ACS Catalysis

The formation of all-cis-(multi)fluorinated piperidines by a dearomatization–hydrogenation process

(2019) Zackaria Nairoukh et al.   Nature Chemistry

Selective Arene Hydrogenation Provides Direct Access to Saturated Carbo- and Heterocycles

(2019) Mario Patrick Wiesenfeldt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress in the Chemistry of Tetrahydroquinolines

(2019) Isravel Muthukrishnan et al.   CHEMICAL REVIEWS

New Chiral Brønsted Acid from Chiral Phosphoric Acid Boron Complex and Water: Asymmetric Reduction of Indoles

(2019) Kai Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Diastereo- and Enantioselective Ir-Catalyzed Hydrogenation of 2,3-Disubstituted Quinolines with Structurally Fine-Tuned Phosphine–Phosphoramidite Ligands

(2019) Xin-Hu Hu et al.   ORGANIC LETTERS

Efficient Asymmetric Hydrogenation of Quinolines over Chiral Porous Polymers Integrated with Substrate Activation Sites

(2019) Lin Tao et al.   ACS Catalysis

Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of 2-Hydroxypyrimidine/Pyrimidin-2(1H )-one Tautomers

(2018) Guang-Shou Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights

(2018) Bo Qu et al.   ORGANIC LETTERS

Brønsted-Acid-Promoted Rh-Catalyzed Asymmetric Hydrogenation of N-Unprotected Indoles: A Cocatalysis of Transition Metal and Anion Binding

(2018) Jialin Wen et al.   ORGANIC LETTERS

Review of deutetrabenazine: a novel treatment for chorea associated with Huntington's disease

(2018) Marissa Dean et al.   Drug Design Development and Therapy

FLP catalysis: main group hydrogenations of organic unsaturated substrates

(2018) Jolie Lam et al.   CHEMICAL SOCIETY REVIEWS

Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles

(2018) Chang-Bin Yu et al.   Organic Chemistry Frontiers

Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys

(2018) Melis Odabas-Geldiay et al.   DRUG AND ALCOHOL DEPENDENCE

Iridium-Catalyzed Asymmetric Hydrogenation of 4,6-Disubstituted 2-Hydroxypyrimidines

(2018) Guang-Shou Feng et al.   ORGANIC LETTERS

Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis

(2018) Eric R. Welin et al.   SCIENCE

Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator

(2017) Mu-Wang Chen et al.   ORGANIC LETTERS

Asymmetric Transfer Hydrogenations of 2,3-Disubstituted Quinoxalines with Ammonia Borane

(2017) Songlei Li et al.   ORGANIC LETTERS

Enantioselective hydrogenation of N-heteroaromatics catalyzed by chiral diphosphine modified binaphthyl palladium nanoparticles

(2017) Yun-Tao Xia et al.   Catalysis Science & Technology

A Mixed Ligand Approach for the Asymmetric Hydrogenation of 2-Substituted Pyridinium Salts

(2016) Marc Renom-Carrasco et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Hydrogenation of 3-Amido-2-arylpyridinium Salts by Triply Chloride-Bridged Dinuclear Iridium Complexes Bearing Enantiopure Diphosphine Ligands: Synthesis of Neurokinin-1 Receptor Antagonist Derivatives

(2016) Atsuhiro Iimuro et al.   ADVANCED SYNTHESIS & CATALYSIS

Efficient Hydrogenation of Nitrogen Heterocycles Catalyzed by Carbon-Metal Covalent Bonds-Stabilized Palladium Nanoparticles: Synergistic Effects of Particle Size and Water

(2016) Yu Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

(2016) Yusuke Makida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2′-Bisquinoline Derivatives

(2016) Wenpeng Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Synthesis of Indolines: Asymmetric Hydrogenation at Ambient Temperature and Pressure with Cationic Ruthenium Diamine Catalysts

(2016) Zhusheng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triply Halide-Bridged Dinuclear Iridium(III) Complexes with Chiral Diphosphine Ligands as New Easy-to-Handle Iridium Catalysts for Asymmetric Hydrogenation of Imines and N -Heteroaromatics

(2016) Kazushi Mashima et al.   CHEMICAL RECORD

The Development of Phosphine-Free "Tethered" Ruthenium(II) Catalysts for the Asymmetric Reduction of Ketones and Imines

(2016) Hans G. Nedden et al.   CHEMICAL RECORD

Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts

(2016) Marc Renom-Carrasco et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Hydrogenation of Seven-Membered C=N-containing Heterocycles and Rationalization of the Enantioselectivity

(2016) Bugga Balakrishna et al.   CHEMISTRY-A EUROPEAN JOURNAL

Homogeneous metal catalysis for conversion between aromatic and saturated compounds

(2016) Zachary X. Giustra et al.   COORDINATION CHEMISTRY REVIEWS

Asymmetric Hydrogenation of Unprotected Indoles Catalyzed by η6-Arene/N-Me-sulfonyldiamine–Ru(II) Complexes

(2016) Taichiro Touge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides

(2016) Wen-Xue Huang et al.   ORGANIC LETTERS

A Cyclometalated Ruthenium-NHC Precatalyst for the Asymmetric Hydrogenation of (Hetero)arenes and Its Activation Pathway

(2016) Daniel Paul et al.   ORGANOMETALLICS

Asymmetric Hydrogenation of Heteroarenes with Multiple Heteroatoms

(2016) Yong-Gui Zhou et al.   SYNTHESIS-STUTTGART

Strong Brønsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh–thiourea chiral phosphine complex via anion binding

(2016) Jialin Wen et al.   Chemical Science

Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics Bearing a Hydroxyl Group, 3-Hydroxypyridinium Salts

(2016) Wen-Xue Huang et al.   ACS Catalysis

Catalytic Asymmetric Hydrogenation of Pyrimidines

(2015) Ryoichi Kuwano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrate Activation in the Catalytic Asymmetric Hydrogenation ofN-Heteroarenes

(2015) Bugga Balakrishna et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and use of an asymmetric transfer hydrogenation catalyst based on iron(II) for the synthesis of enantioenriched alcohols and amines

(2015) Weiwei Zuo et al.   Nature Protocols

Enantioselective Metal-Free Hydrogenations of Disubstituted Quinolines

(2015) Zhenhua Zhang et al.   ORGANIC LETTERS

Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial

(2015) Neely Ivgy-May et al.   SLEEP MEDICINE

Asymmetric Homogeneous Hydrogenation of 2-Pyridones

(2015) Frank Glorius et al.   SYNLETT

Nature loves nitrogen heterocycles

(2015) Christopher T. Walsh   TETRAHEDRON LETTERS

Enantioselective synthesis of trifluoromethyl substituted piperidines with multiple stereogenic centers via hydrogenation of pyridinium hydrochlorides

(2015) Mu-Wang Chen et al.   Organic Chemistry Frontiers

Assymmetric Ir-catalyzed hydrogenation of 2-methylindole using phosphite-type ligands

(2015) D. V. Ozolin et al.   RUSSIAN CHEMICAL BULLETIN

Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst

(2014) Mingxin Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines

(2014) Xian-Feng Cai et al.   CHEMICAL COMMUNICATIONS

Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines

(2014) Xian-Feng Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chiral Ru/Ir bimetallic dendronized polymer catalysts constructed through sequential metal coordination and applied in asymmetric hydrogenation of quinaldine

(2014) Yi-Yong Huang et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Homogenous Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope and Mechanistic Studies

(2014) Ying Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

(2014) Bradley Petek et al.   MOLECULES

Iridium-Catalyzed Asymmetric Hydrogenation of Pyrrolo[1,2-a]pyrazinium Salts

(2014) Wen-Xue Huang et al.   ORGANIC LETTERS

Chiral Phosphoric Acid-Catalyzed Asymmetric Transfer Hydrogenation of Quinolin-3-amines

(2014) Xian-Feng Cai et al.   ORGANIC LETTERS

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance ofPlasmodium

(2014) María Belén Jiménez-Díaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric iridium-catalyzed hydrogenation of 2-methylindole using phosphite ligands

(2014) Sergey E. Lyubimov et al.   TETRAHEDRON LETTERS

Ruthenium-NHC-Catalyzed Asymmetric Hydrogenation of Indolizines: Access to Indolizidine Alkaloids

(2013) Nuria Ortega et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts

(2013) Zhi-Shi Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of Isoquinolinium Salts Catalyzed by Chiral Iridium Complexes: Direct Synthesis for Optically Active 1,2,3,4-Tetrahydroisoquinolines

(2013) Atsuhiro Iimuro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Robust cyclometallated Ir(iii) catalysts for the homogeneous hydrogenation of N-heterocycles under mild conditions

(2013) Jianjun Wu et al.   CHEMICAL COMMUNICATIONS

An efficient route to chiral N-heterocycles bearing a C–F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines

(2013) Ran-Ning Guo et al.   CHEMICAL COMMUNICATIONS

Iridium-catalyzed Asymmetric Hydrogenation of Pyridinium Salts for Constructing Multiple Stereogenic Centers on Piperidines

(2013) Yusuke Kita et al.   CHEMISTRY LETTERS

Asymmetric hydrogenation of unprotected indoles using iridium complexes derived from P–OP ligands and (reusable) Brønsted acids

(2013) José Luis Núñez-Rico et al.   GREEN CHEMISTRY

Metal-Free Borane-Catalyzed Highly Stereoselective Hydrogenation of Pyridines

(2013) Yongbing Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[Ir(P−OP)]-Catalyzed Asymmetric Hydrogenation of Diversely Substituted C═N-Containing Heterocycles

(2013) José Luis Núñez-Rico et al.   ORGANIC LETTERS

Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines

(2013) Anna M. Maj et al.   TETRAHEDRON

Iridium-Catalyzed Asymmetric Hydrogenation of Substituted Pyridines

(2013) Alban Cadu et al.   Asian Journal of Organic Chemistry

Efficient and Chemoselective Reduction of Pyridines to Tetrahydropyridines and PiperidinesviaRhodium-Catalyzed Transfer Hydrogenation

(2012) Jianjun Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Brønsted Acid Activation Strategy in Transition-Metal Catalyzed Asymmetric Hydrogenation of N-Unprotected Imines, Enamines, and N-Heteroaromatic Compounds

(2012) Zhengkun Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Iridium-Catalyzed Hydrogenation of 3,4-Disubstituted Isoquinolines

(2012) Lei Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts

(2012) Zhi-Shi Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

(2012) Anthony D. Pechulis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transfer hydrogenation with Hantzsch esters and related organic hydride donors

(2012) Chao Zheng et al.   CHEMICAL SOCIETY REVIEWS

Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs

(2012) Pablo Etayo et al.   CHEMICAL SOCIETY REVIEWS

Additive Effects of Amines on Asymmetric Hydrogenation of Quinoxalines Catalyzed by Chiral Iridium Complexes

(2012) Takuto Nagano et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Remarkable Effect of a Simple Ion: Iodide-Promoted Transfer Hydrogenation of Heteroaromatics

(2012) Jianjun Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters

(2012) Nadeem S. Sheikh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphine−Phosphinite and Phosphine−Phosphite Ligands: Preparation and Applications in Asymmetric Catalysis

(2011) Héctor Fernández-Pérez et al.   CHEMICAL REVIEWS

Advances in the Chemistry of Tetrahydroquinolines

(2011) Vellaisamy Sridharan et al.   CHEMICAL REVIEWS

Asymmetric Hydrogenation of Heteroarenes and Arenes

(2011) Duo-Sheng Wang et al.   CHEMICAL REVIEWS

Highly Enantioselective Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope, Mechanism, and Origin of Enantioselectivity

(2011) Tianli Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Hydrogenation of 2- and 2,3-Substituted Quinoxalines with Chiral Cationic Ruthenium Diamine Catalysts

(2011) Jie Qin et al.   ORGANIC LETTERS

Highly Enantioselective Hydrogenation of Quinoline and Pyridine Derivatives with Iridium-(P-Phos) Catalyst

(2010) Wei-Jun Tang et al.   ADVANCED SYNTHESIS & CATALYSIS

Tetrahydroquinoline derivatives as opioid receptor antagonists

(2010) Cunyu Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metal-free reductions of N-heterocycles via Lewis acid catalyzed hydrogenation

(2010) Stephen J. Geier et al.   CHEMICAL COMMUNICATIONS

Iridium-Catalyzed Asymmetric Hydrogenation of Imines

(2010) Alejandro Baeza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iridium-Catalyzed Asymmetric Hydrogenation of N-Protected Indoles

(2010) Alejandro Baeza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Brønsted Acids

(2010) Duo-Sheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst

(2010) Weijun Tang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antibacterial Activity of Synthetic Fire Ant Venom: The Solenopsins and Isosolenopsins

(2009) Donna C. Sullivan et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones

(2009) Bin Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Novel Bis-Thiourea Organocatalyst for the Asymmetric Aza-Henry Reaction

(2008) Constantinos Rampalakos et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly ModularP-O-PLigands for Asymmetric Hydrogenation

(2008) Héctor Fernández-Pérez et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of (S)-Mirtazapine: Unexpected Racemization through an Aromaticipso-Attack Mechanism

(2008) Marco van der Linden et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Tunable Bisphosphine Ligands and Their Application in Asymmetric Hydrogenation of Quinolines

(2008) Xiao-Bing Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Hydrogenation of Cyclic Imines with an Ionic Cp*Rh(III) Catalyst

(2008) Chaoqun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-catalyzed asymmetric hydrogenation of pyridine derivatives, 7,8-dihydro-quinolin-5(6H)-ones

(2008) Xiao-Bing Wang et al.   TETRAHEDRON LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS