Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma

Roles of the BAP1 tumor suppressor in cell metabolism

(2021) Anna Han et al.   CANCER RESEARCH

The AMP‐dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma

(2021) Vivian Chua et al.   Pigment Cell & Melanoma Research

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

(2020) Michael A. Durante et al.   Nature Communications

Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

(2020) Peter A. Johansson et al.   Nature Communications

Molecular profiling of driver events in metastatic uveal melanoma

(2020) Joakim Karlsson et al.   Nature Communications

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

(2020) Jie Li et al.   Science Signaling

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

(2020) Michele Carbone et al.   Cancer Discovery

The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019)

(2020) Vivian Chua et al.   CLINICAL CANCER RESEARCH

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

(2020) Zhen Cai et al.   MOLECULAR CELL

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications

(2020) Qinyao Wei et al.   ONCOGENE

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors

(2020) Anna Han et al.   ONCOGENE

Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma

(2019) Vivian Chua et al.   EMBO Molecular Medicine

Annotation of gene product function from high-throughput studies using the Gene Ontology

(2019) Helen Attrill et al.   Database-The Journal of Biological Databases and Curation

Inhibition of pyruvate dehydrogenase kinase enhances the antitumor efficacy of oncolytic reovirus

(2019) Barry E Kennedy et al.   CANCER RESEARCH

Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth

(2019) Ekta Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

BAP1 in solid tumors

(2019) Vincenzo Di Nunno et al.   Future Oncology

The genetic evolution of metastatic uveal melanoma

(2019) A. Hunter Shain et al.   NATURE GENETICS

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

(2019) Peter Kreuzaler et al.   Molecular Metabolism

Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study

(2019) Markus V. Heppt et al.   Journal for ImmunoTherapy of Cancer

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

The contributions of cancer cell metabolism to metastasis

(2018) Gloria Pascual et al.   Disease Models & Mechanisms

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

(2018) Richard D. Carvajal et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Synergy of Sex Differences in Visceral Fat Measured with CT and Tumor Metabolism Helps Predict Overall Survival in Patients with Renal Cell Carcinoma

(2018) Gerard K. Nguyen et al.   RADIOLOGY

Punctuated evolution of canonical genomic aberrations in uveal melanoma

(2018) Matthew G. Field et al.   Nature Communications

PTEN: Tumor Suppressor and Metabolic Regulator

(2018) Chien-Yu Chen et al.   Frontiers in Endocrinology

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

(2018) Dominic Lapadula et al.   MOLECULAR CANCER RESEARCH

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma

(2017) Hanyin Cheng et al.   MOLECULAR CANCER THERAPEUTICS

Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function

(2017) Lucie Hebert et al.   Oncotarget

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Gene of the month:BAP1

(2016) Ami Wang et al.   JOURNAL OF CLINICAL PATHOLOGY

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

(2016) Josiah E. Hutton et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

(2016) Joshua M. Baughman et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

(2015) Wen Zhang et al.   International Journal of Biological Sciences

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents

(2015) Elise Saunier et al.   INTERNATIONAL JOURNAL OF CANCER

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing

(2014) H Kalirai et al.   BRITISH JOURNAL OF CANCER

The potential role of O-GlcNAc modification in cancer epigenetics

(2014) Ewa Forma et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target

(2014) Nabil Amirouchene-Angelozzi et al.   Molecular Oncology

Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice

(2014) Jenna Pekkinen et al.   Nutrition & Metabolism

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

(2012) Hai-Bin Ruan et al.   Cell Metabolism

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

(2011) Zuzana Zachar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE