BAP1 in solid tumors

Comprehensive molecular profiling of intra- and extrahepatic cholangiocarcinomas: potential targets for intervention

(2018) Maeve A Lowery et al.   CLINICAL CANCER RESEARCH

Analysis of the Exome Aggregation Consortium (ExAC) database suggests that the BAP1-t umor predisposition syndrome is underreported in cancer patients

(2018) James B. Massengill et al.   GENES CHROMOSOMES & CANCER

Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma

(2018) Serena Patrone et al.   GENES CHROMOSOMES & CANCER

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

(2018) Christopher P. Wardell et al.   JOURNAL OF HEPATOLOGY

Detecting germline BAP1 mutations in patients with peritoneal mesothelioma: benefits to patient and family members

(2018) Muaiad Kittaneh et al.   Journal of Translational Medicine

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma

(2018) Wondossen Sime et al.   Cell Death & Disease

Nuclear BAP1 loss is common in intrahepatic cholangiocarcinoma and a subtype of hepatocellular carcinoma but rare in pancreatic ductal adenocarcinoma

(2018) Asmaa Mosbeh et al.   Cancer Genetics

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

(2018) Christopher J. Ricketts et al.   Cell Reports

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

(2018) Krishna Kalyan Kolluri et al.   eLife

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma

(2018) Vasiliki Panou et al.   JOURNAL OF CLINICAL ONCOLOGY

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Nuclear grading, BAP1, mesothelin and PD-L1 expression in malignant pleural mesothelioma: prognostic implications

(2018) Fabien Forest et al.   PATHOLOGY

Chromosome 3p Loss–Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma

(2018) James J. Hsieh et al.   JOURNAL OF CLINICAL ONCOLOGY

A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations

(2018) Sandra Pastorino et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma

(2017) James J. Hsieh et al.   EUROPEAN UROLOGY

Cholangiocarcinoma: Current Knowledge and New Developments

(2017) Boris Blechacz   Gut and Liver

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries

(2017) Andrea Farioli et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance

(2017) Guan-Zhong Qiu et al.   PHARMACOLOGY & THERAPEUTICS

Intrahepatic cholangiocarcinoma: current perspectives

(2017) Stefan Buettner et al.   OncoTargets and Therapy

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

(2017) Apinya Jusakul et al.   Cancer Discovery

Diagnostic accuracy of BRCA1–associated protein 1 in malignant mesothelioma: a meta-analysis

(2017) Li-Ming Wang et al.   Oncotarget

Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function

(2017) Lucie Hebert et al.   Oncotarget

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

(2017) Jeanette E. Eckel-Passow et al.   BMC Urology

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

(2017) Farshad Farshidfar et al.   Cell Reports

Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets

(2017) Douglas V.N.P. Oliveira et al.   Expert Review of Gastroenterology & Hepatology

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

Comparing the Prognostic Value of BAP1 Mutation Pattern, Chromosome 3 Status, and BAP1 Immunohistochemistry in Uveal Melanoma

(2016) Johannes A.P. van de Nes et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma

(2016) M. Betti et al.   CANCER LETTERS

The prospect of precision therapy for renal cell carcinoma

(2016) Chiara Ciccarese et al.   CANCER TREATMENT REVIEWS

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

Consensus Report of the 2015 Weinman International Conference on Mesothelioma

(2016) Michele Carbone et al.   Journal of Thoracic Oncology

The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing

(2016) Marieke Hylebos et al.   Journal of Thoracic Oncology

Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma

(2016) Juliana Andrici et al.   MEDICINE

High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma

(2016) Yoshie Yoshikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAP1,PBRM1andSETD2in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies

(2015) Francesco Piva et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma

(2015) Masaki Nasu et al.   Journal of Thoracic Oncology

BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations

(2015) Marta Cigognetti et al.   MODERN PATHOLOGY

A river model to map convergent cancer evolution and guide therapy in RCC

(2015) Elizabeth Y. Wei et al.   Nature Reviews Urology

Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma

(2015) A Napolitano et al.   ONCOGENE

Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

(2015) Joseph J. Sacco et al.   Oncotarget

Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma

(2015) Francesco Piva et al.   Oncotarget

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

(2014) J. Xu et al.   CANCER RESEARCH

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

(2014) John Bridgewater et al.   JOURNAL OF HEPATOLOGY

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors

(2014) Iacopo Petrini et al.   NATURE GENETICS

Bap1is essential for kidney function and cooperates withVhlin renal tumorigenesis

(2014) Shan-Shan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Mutations of epigenetic regulatory genes are common in thymic carcinomas

(2014) Yisong Wang et al.   Scientific Reports

Asbestos: a hidden player behind the cholangiocarcinoma increase? Findings from a case–control analysis

(2013) Giovanni Brandi et al.   CANCER CAUSES & CONTROL

Cisplatin Resistance Associated with PARP Hyperactivation

(2013) J. Michels et al.   CANCER RESEARCH

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

(2013) Waraporn Chan-on et al.   NATURE GENETICS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes

(2012) Mina Komuta et al.   HEPATOLOGY

BAP1 loss defines a new class of renal cell carcinoma

(2012) Samuel Peña-Llopis et al.   NATURE GENETICS

Tumours associated with BAP1 mutations

(2012) Rajmohan Murali et al.   PATHOLOGY

A Phase II Trial of Panobinostat, a Histone Deacetylase Inhibitor, in the Treatment of Patients with Refractory Metastatic Renal Cell Carcinoma

(2011) John D. Hainsworth et al.   CANCER INVESTIGATION

An Emerging Model for BAP1’s Role in Regulating Cell Cycle Progression

(2011) Ziad M. Eletr et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Thymic Malignancies: From Clinical Management to Targeted Therapies

(2011) Ronan J. Kelly et al.   JOURNAL OF CLINICAL ONCOLOGY

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

(2011) Matthew Bott et al.   NATURE GENETICS

Germline BAP1 mutations predispose to malignant mesothelioma

(2011) Joseph R Testa et al.   NATURE GENETICS

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1

(2009) Yuichi J. Machida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

(2008) H. Nishikawa et al.   CANCER RESEARCH

The VHL tumor suppressor and HIF: insights from genetic studies in mice

(2008) P P Kapitsinou et al.   CELL DEATH AND DIFFERENTIATION

Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin

(2008) Mina Komuta et al.   HEPATOLOGY