TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21

(2020) Wenzhe Si et al.   Cell Death & Disease

Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation

(2020) Abhishek Guha et al.   Scientific Reports

TRIM21 Is Decreased in Colitis-associated Cancer and Negatively Regulates Epithelial Carcinogenesis

(2020) Guangxi Zhou et al.   INFLAMMATORY BOWEL DISEASES

Neddylation of PTEN regulates its nuclear import and promotes tumor development

(2020) Ping Xie et al.   CELL RESEARCH

MRE11 UFMylation promotes ATM activation

(2019) Zhifeng Wang et al.   NUCLEIC ACIDS RESEARCH

Emerging RNA-binding roles in the TRIM family of ubiquitin ligases

(2019) Felix Preston Williams et al.   BIOLOGICAL CHEMISTRY

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

(2019) Venuto et al.   Cells

TRIM21—From Intracellular Immunity to Therapy

(2019) Stian Foss et al.   Frontiers in Immunology

Claspin - checkpoint adaptor and DNA replication factor

(2018) Veronique A. J. Smits et al.   FEBS Journal

Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif–containing 21

(2018) Junji Itou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB

(2018) Dorthe Aasland et al.   CANCER RESEARCH

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ataxin-3 promotes genome integrity by stabilizing Chk1

(2017) Yingfeng Tu et al.   NUCLEIC ACIDS RESEARCH

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

A review of the role and clinical utility of anti-Ro52/TRIM21 in systemic autoimmunity

(2017) Adrian Y. S. Lee   RHEUMATOLOGY INTERNATIONAL

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

(2017) Monica Benini et al.   Cell Reports

53BP1 and BRCA1 control pathway choice for stalled replication restart

(2017) Yixi Xu et al.   eLife

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase

(2016) Edel McGarry et al.   CANCER RESEARCH

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

(2016) Haoxing Zhang et al.   Nature Communications

Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage

(2016) Hervé Técher et al.   Cell Reports

Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers

(2015) Qianshan Ding et al.   TUMOR BIOLOGY

Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway

(2014) N. C. Kyriakidis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

(2014) B. Ashok Reddy et al.   MOLECULAR CELL

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

(2014) Jian Yuan et al.   NUCLEIC ACIDS RESEARCH

HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability

(2014) Min Zhu et al.   NUCLEIC ACIDS RESEARCH

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination

(2014) Y Martín et al.   ONCOGENE

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

(2014) Elisa Lazzari et al.   PLoS One

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

(2013) Ivana Murfuni et al.   PLoS Genetics

Replication fork dynamics and the DNA damage response

(2012) Rebecca M. Jones et al.   BIOCHEMICAL JOURNAL

The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1

(2012) Shizhou Liu et al.   CELL CYCLE

A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair

(2012) Ko Sato et al.   CURRENT BIOLOGY

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

K63-Linked Ubiquitination in Kinase Activation and Cancer

(2012) Guocan Wang et al.   Frontiers in Oncology

Characterization of functional domains in human Claspin

(2011) Özdemirhan Serçin et al.   CELL CYCLE

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

(2010) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

(2009) Helene Faustrup et al.   JOURNAL OF CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

(2008) Florian Bassermann et al.   CELL