Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

(2021) Kellie D. Nance et al.   ACS Central Science

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

(2021) Ugur Sahin et al.   NATURE

Extraction of mRNA from Stalled Ribosomes by the Ski Complex

(2020) Alexandra Zinoviev et al.   MOLECULAR CELL

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

(2020) Chen Bao et al.   eLife

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane

(2020) Molly M Hannigan et al.   MOLECULAR & CELLULAR PROTEOMICS

The ASC-1 Complex Disassembles Collided Ribosomes

(2020) Szymon Juszkiewicz et al.   MOLECULAR CELL

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs

(2019) Thomas Philipp Hoernes et al.   Genes

The Organizing Principles of Eukaryotic Ribosome Recruitment

(2019) Jerry Pelletier et al.   Annual Review of Biochemistry

The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

(2019) Karole N D'Orazio et al.   eLife

Ribosome pausing, a dangerous necessity for co-translational events

(2019) Martine A Collart et al.   NUCLEIC ACIDS RESEARCH

eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons

(2019) Qian Yang et al.   NUCLEIC ACIDS RESEARCH

Ribosome Collisions Result in +1 Frameshifting in the Absence of No-Go Decay

(2019) Carrie L. Simms et al.   Cell Reports

mRNA structure regulates protein expression through changes in functional half-life

(2019) David M. Mauger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudouridinylation of mRNA coding sequences alters translation

(2019) Daniel E. Eyler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control

(2018) Alina Guna et al.   CURRENT BIOLOGY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Roadblocks and resolutions in eukaryotic translation

(2018) Anthony P. Schuller et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

(2018) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translation Termination and Ribosome Recycling in Eukaryotes

(2018) Christopher U.T. Hellen   Cold Spring Harbor Perspectives in Biology

Toward a Kinetic Understanding of Eukaryotic Translation

(2018) Masaaki Sokabe et al.   Cold Spring Harbor Perspectives in Biology

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

(2018) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The extent of ribosome queuing in budding yeast

(2018) Alon Diament et al.   PLoS Computational Biology

Timing during translation matters: synonymous mutations in human pathologies influence protein folding and function

(2018) Robert Rauscher et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

(2018) Ayala Shiber et al.   NATURE

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

Ribosome Collision Is Critical for Quality Control during No-Go Decay

(2017) Carrie L. Simms et al.   MOLECULAR CELL

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

(2017) Yuri V. Svitkin et al.   NUCLEIC ACIDS RESEARCH

Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells

(2017) Fangzhou Zhao et al.   NUCLEIC ACIDS RESEARCH

Three tRNAs on the ribosome slow translation elongation

(2017) Junhong Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

(2017) Aitor Garzia et al.   Nature Communications

Single-Molecule Quantification of Translation-Dependent Association of mRNAs with the Endoplasmic Reticulum

(2017) Franka Voigt et al.   Cell Reports

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

(2016) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autonomous translational pausing is required forXBP1umRNA recruitment to the ER via the SRP pathway

(2016) Satoshi Kanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ribosome in action: Tuning of translational efficiency and protein folding

(2016) Marina V. Rodnina   PROTEIN SCIENCE

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

(2016) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome

(2015) Xiaoyu Li et al.   Nature Chemical Biology

Diversity and selectivity in mRNA translation on the endoplasmic reticulum

(2015) David W. Reid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code

(2015) Thomas Philipp Hoernes et al.   NUCLEIC ACIDS RESEARCH

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation

(2014) C. Pop et al.   Molecular Systems Biology

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

(2014) Thomas M. Carlile et al.   NATURE

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

(2014) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptome-Wide Mapping of Pseudouridines: Pseudouridine Synthases Modify Specific mRNAs in S. cerevisiae

(2014) Alexander F. Lovejoy et al.   PLoS One

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

The contribution of pseudouridine to stabilities and structure of RNAs

(2013) Elzbieta Kierzek et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

Rationalization and prediction of selective decoding of pseudouridine-modified nonsense and sense codons

(2012) M. Parisien et al.   RNA

Primary Role for Endoplasmic Reticulum-bound Ribosomes in Cellular Translation Identified by Ribosome Profiling

(2011) David W. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

Regulation of innate immunity through RNA structure and the protein kinase PKR

(2010) Subba Rao Nallagatla et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

New Insights into the Role of RNase L in Innate Immunity

(2010) Arindam Chakrabarti et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation

(2008) Yuri V Svitkin et al.   EMBO JOURNAL

Ribosome Collisions and Translation Efficiency: Optimization by Codon Usage and mRNA Destabilization

(2008) Namiko Mitarai et al.   JOURNAL OF MOLECULAR BIOLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Following translation by single ribosomes one codon at a time

(2008) Jin-Der Wen et al.   NATURE

A pause for thought along the co-translational folding pathway

(2008) Anton A. Komar   TRENDS IN BIOCHEMICAL SCIENCES

Divergent Regulation of Protein Synthesis in the Cytosol and Endoplasmic Reticulum Compartments of Mammalian Cells

(2007) Samuel B. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL