Timing during translation matters: synonymous mutations in human pathologies influence protein folding and function

Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics

(2018) Taha Ahmad et al.   BIOCHEMICAL PHARMACOLOGY

Alteration of protein function by a silent polymorphism linked to tRNA abundance

(2017) Sebastian Kirchner et al.   PLOS BIOLOGY

Widespread position-specific conservation of synonymous rare codons within coding sequences

(2017) Julie L. Chaney et al.   PLoS Computational Biology

Genome-Wide Analysis of RNA Secondary Structure

(2016) Philip C. Bevilacqua et al.   Annual Review of Genetics

Intron retention resulting from a silent mutation in the VWF gene that structurally influences the 5' splice site

(2016) H. Yadegari et al.   BLOOD

Quality over quantity: optimizing co-translational protein folding with non-‘optimal’ synonymous codons

(2016) Giselle N Jacobson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The importance of mRNA structure in determining the pathogenicity of synonymous and non-synonymous mutations in haemophilia

(2016) N. Hamasaki-Katagiri et al.   HAEMOPHILIA

The Yin and Yang of codon usage

(2016) Anton A. Komar   HUMAN MOLECULAR GENETICS

SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo

(2016) Damon Huber et al.   JOURNAL OF BACTERIOLOGY

Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B

(2016) Vijaya L Simhadri et al.   JOURNAL OF MEDICAL GENETICS

A genetic basis for multiple sclerosis severity: Red herring or real?

(2016) Vilija G. Jokubaitis et al.   MOLECULAR AND CELLULAR PROBES

Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium

(2016) Deepa Agashe et al.   MOLECULAR BIOLOGY AND EVOLUTION

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Global profiling of SRP interaction with nascent polypeptides

(2016) Daniela Schibich et al.   NATURE

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Temperature-responsive in vitro RNA structurome ofYersinia pseudotuberculosis

(2016) Francesco Righetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease

(2016) Hans Matsson et al.   BMC Pulmonary Medicine

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

(2016) Guido Veit et al.   PLOS BIOLOGY

Roles for Synonymous Codon Usage in Protein Biogenesis

(2015) Julie L. Chaney et al.   Annual Review of Biophysics

Genetic Study of Complex Diseases in the Post-GWAS Era

(2015) Qingyang Huang   Journal of Genetics and Genomics

Synonymous Codon Usage Affects the Expression of Wild Type and F508del CFTR

(2015) Kalpit Shah et al.   JOURNAL OF MOLECULAR BIOLOGY

Nonoptimal codon usage influences protein structure in intrinsically disordered regions

(2015) Mian Zhou et al.   MOLECULAR MICROBIOLOGY

Conservation of CFTR codon frequency through primates suggests synonymous mutations could have a functional effect

(2015) Lucilla Pizzo et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes

(2015) Patricia P. Chan et al.   NUCLEIC ACIDS RESEARCH

Operon structure and cotranslational subunit association direct protein assembly in bacteria

(2015) Y.-W. Shieh et al.   SCIENCE

Translational tuning optimizes nascent protein folding in cells

(2015) S. J. Kim et al.   SCIENCE

Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function

(2015) Cristian Del Campo et al.   PLoS Genetics

Silent Mutations Make Some Noise

(2014) Siyuan Zheng et al.   CELL

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

(2014) Fran Supek et al.   CELL

The transcriptional activities and cellular localization of the human estrogen receptor alpha are affected by the synonymous Ala87 mutation

(2014) Tamara Fernández-Calero et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Contribution of Silent Mutations to Thermal Adaptation of RNA Bacteriophage Q 

(2014) A. Kashiwagi et al.   JOURNAL OF VIROLOGY

A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape

(2014) Elad Firnberg et al.   MOLECULAR BIOLOGY AND EVOLUTION

Landscape and variation of RNA secondary structure across the human transcriptome

(2014) Yue Wan et al.   NATURE

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

(2014) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adaptive synonymous mutations in an experimentally evolved Pseudomonas fluorescens population

(2014) Susan F. Bailey et al.   Nature Communications

Efficient translation initiation dictates codon usage at gene start

(2013) K. Bentele et al.   Molecular Systems Biology

Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo

(2013) Silvi Rouskin et al.   NATURE

Causes and Effects of N-Terminal Codon Bias in Bacterial Genes

(2013) D. B. Goodman et al.   SCIENCE

Different mutation profiles associated to P53 accumulation in colorectal cancer

(2012) Ignacio López et al.   GENE

Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme

(2012) Deepa Agashe et al.   MOLECULAR BIOLOGY AND EVOLUTION

Sensitive measurement of single-nucleotide polymorphism-induced changes of RNA conformation: application to disease studies

(2012) Raheleh Salari et al.   NUCLEIC ACIDS RESEARCH

Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo

(2011) Eugene Oh et al.   CELL

Polymorphisms in Surfactant Protein–D Are Associated with Chronic Obstructive Pulmonary Disease

(2010) Marilyn G. Foreman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

How the Sequence of a Gene Can Tune Its Translation

(2010) Kurt Fredrick et al.   CELL

Folding at the birth of the nascent chain: coordinating translation with co-translational folding

(2010) Gong Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different sequence signatures in the upstream regions of plant and animal tRNA genes shape distinct modes of regulation

(2010) Gong Zhang et al.   NUCLEIC ACIDS RESEARCH

Independent Contribution of Common CFTR Variants to Chronic Pancreatitis

(2010) Rafael de Cid et al.   PANCREAS

Mutational Robustness of Ribosomal Protein Genes

(2010) P. A. Lind et al.   SCIENCE

Natural Selection on Synonymous and Nonsynonymous Mutations Shapes Patterns of Polymorphism in Populus tremula

(2009) P. K. Ingvarsson   MOLECULAR BIOLOGY AND EVOLUTION

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Generic Algorithm to Predict the Speed of Translational Elongation: Implications for Protein Biogenesis

(2009) Gong Zhang et al.   PLoS One

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE