Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Homeostatic synaptic scaling establishes the specificity of an associative memory

(2021) Chi-Hong Wu et al.   CURRENT BIOLOGY

Biophysical and synaptic properties of NMDA receptors in the lateral habenula

(2021) Alvaro Nuno-Perez et al.   NEUROPHARMACOLOGY

Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research

(2021) Zhaoxia Yu et al.   NEURON

Networks of habenula-projecting cortical neurons regulate cocaine seeking

(2021) Victor P. Mathis et al.   Science Advances

Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors

(2020) Marcus Stephenson-Jones et al.   NEURON

Memory engrams: Recalling the past and imagining the future

(2020) Sheena A. Josselyn et al.   SCIENCE

Circuits and functions of the lateral habenula in health and in disease

(2020) Hailan Hu et al.   NATURE REVIEWS NEUROSCIENCE

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

(2020) Yuji Nagai et al.   NATURE NEUROSCIENCE

A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement

(2020) Xiong Xiao et al.   CELL

NMDA receptor-dependent long-term depression in the lateral habenula: implications in physiology and depression

(2020) Miseon Kang et al.   Scientific Reports

Lateral Habenular Burst Firing as a Target of the Rapid Antidepressant Effects of Ketamine

(2019) Yihui Cui et al.   TRENDS IN NEUROSCIENCES

A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy

(2019) Lu Huang et al.   NEURON

Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses

(2019) Massimo Trusel et al.   NEURON

A hypothalamus-habenula circuit controls aversion

(2019) Iakovos Lazaridis et al.   MOLECULAR PSYCHIATRY

Valence-encoding in the lateral habenula arises from the entopeduncular region

(2019) Hao Li et al.   eLife

Stress transforms lateral habenula reward responses into punishment signals

(2019) Steven J. Shabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

(2019) Ignas Cerniauskas et al.   NEURON

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

(2018) Jessica Tooley et al.   BIOLOGICAL PSYCHIATRY

Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum

(2018) Lauren Faget et al.   Nature Communications

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

In vivo measurement of afferent activity with axon-specific calcium imaging

(2018) Gerard Joey Broussard et al.   NATURE NEUROSCIENCE

Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway

(2018) Guang-Wei Zhang et al.   NEURON

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula

(2017) Hoyong Park et al.   JOURNAL OF NEUROSCIENCE

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

(2017) Anna Tchenio et al.   Nature Communications

Selectively Impaired Endocannabinoid-Dependent Long-Term Depression in the Lateral Habenula in an Animal Model of Depression

(2017) Hoyong Park et al.   Cell Reports

Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission

(2017) David J. Barker et al.   Cell Reports

Learning shapes the aversion and reward responses of lateral habenula neurons

(2017) Daqing Wang et al.   eLife

Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior

(2017) Salvatore Lecca et al.   eLife

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

(2016) A. M. Stamatakis et al.   JOURNAL OF NEUROSCIENCE

A thalamic input to the nucleus accumbens mediates opiate dependence

(2016) Yingjie Zhu et al.   NATURE

A basal ganglia circuit for evaluating action outcomes

(2016) Marcus Stephenson-Jones et al.   NATURE

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

(2016) Salvatore Lecca et al.   NATURE MEDICINE

Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

(2016) Frank J Meye et al.   NATURE NEUROSCIENCE

Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

(2016) Ji Hoon Yoo et al.   Nature Communications

mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output

(2016) Kristina Valentinova et al.   Cell Reports

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

(2015) Frank J Meye et al.   NATURE NEUROSCIENCE

Habenula Lesions Reveal that Multiple Mechanisms Underlie Dopamine Prediction Errors

(2015) Ju Tian et al.   NEURON

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

(2014) Salvatore Lecca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of Glutamatergic Projections from Ventral Tegmental Area to Lateral Habenula in Aversive Conditioning

(2014) D. H. Root et al.   JOURNAL OF NEUROSCIENCE

Reward processing by the lateral habenula in normal and depressive behaviors

(2014) Christophe D Proulx et al.   NATURE NEUROSCIENCE

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

(2014) S. J. Shabel et al.   SCIENCE

 CaMKII in Lateral Habenula Mediates Core Symptoms of Depression

(2013) K. Li et al.   SCIENCE

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin

(2012) Steven J. Shabel et al.   NEURON

The Spike-Timing Dependence of Plasticity

(2012) Daniel E. Feldman   NEURON

Neurobiology of chronic mild stress: Parallels to major depression

(2012) Matthew N. Hill et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Behavioral animal models of depression

(2010) Hua-Cheng Yan et al.   Neuroscience Bulletin

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient

(2009) Alexander Sartorius et al.   BIOLOGICAL PSYCHIATRY

Habenula: Crossroad between the Basal Ganglia and the Limbic System

(2008) O. Hikosaka et al.   JOURNAL OF NEUROSCIENCE

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE