The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat

(2013) Wolfram C. Poller et al.   BRAIN RESEARCH

Substance P receptor antagonist in lateral habenula improves rat depression-like behavior

(2013) Li-Min Yang et al.   BRAIN RESEARCH BULLETIN

A new translational target for deep brain stimulation to treat depression

(2013) Karl Kiening et al.   EMBO Molecular Medicine

Dopamine D4Receptor Excitation of Lateral Habenula Neurons via Multiple Cellular Mechanisms

(2013) Cameron H. Good et al.   JOURNAL OF NEUROSCIENCE

The Synchronous Activity of Lateral Habenular Neurons Is Essential for Regulating Hippocampal Theta Oscillation

(2013) H. Aizawa et al.   JOURNAL OF NEUROSCIENCE

Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways

(2013) T. C. Jhou et al.   JOURNAL OF NEUROSCIENCE

What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases

(2013) Colin M Stopper et al.   NATURE NEUROSCIENCE

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons

(2013) Wanhong Zuo et al.   NEUROPHARMACOLOGY

Neurodegeneration of lateral habenula efferent fibers after intermittent cocaine administration: Implications for deep brain stimulation

(2013) Elad Lax et al.   NEUROPHARMACOLOGY

Differential contribution of mesoaccumbens and mesohabenular dopamine to intracranial self-stimulation

(2013) Vincent Duchesne et al.   NEUROPHARMACOLOGY

Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability

(2013) Christie D. Fowler et al.   NEUROPHARMACOLOGY

Habenula and ADHD: Convergence on time

(2013) Young-A. Lee et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The lateral habenula is a common target of cocaine and dexamethasone

(2013) Chun-Xiao Zhang et al.   NEUROSCIENCE LETTERS

Inactivation of the lateral habenula reduces anxiogenic behavior and cocaine seeking under conditions of heightened stress

(2013) Margaret J. Gill et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Lesions of the Fasciculus Retroflexus Alter Footshock-Induced cFos Expression in the Mesopontine Rostromedial Tegmental Area of Rats

(2013) Paul Leon Brown et al.   PLoS One

 CaMKII in Lateral Habenula Mediates Core Symptoms of Depression

(2013) K. Li et al.   SCIENCE

Mechanisms of dopamine transporter regulation in normal and disease states

(2013) Roxanne A. Vaughan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Addiction is a Reward Deficit and Stress Surfeit Disorder

(2013) George F. Koob   Frontiers in Psychiatry

DREADDing the lateral habenula: A review of methodological approaches for studying lateral habenula function

(2012) Sunila G. Nair et al.   BRAIN RESEARCH

Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat

(2012) Uhnoh Kim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular characterization of the subnuclei in rat habenula

(2012) Hidenori Aizawa et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cocaine Evokes Projection-Specific Synaptic Plasticity of Lateral Habenula Neurons

(2012) M. Maroteaux et al.   JOURNAL OF NEUROSCIENCE

Ventral Tegmental Area Glutamate Neurons: Electrophysiological Properties and Projections

(2012) T. S. Hnasko et al.   JOURNAL OF NEUROSCIENCE

Fos Activation of Selective Afferents to Ventral Tegmental Area during Cue-Induced Reinstatement of Cocaine Seeking in Rats

(2012) S. V. Mahler et al.   JOURNAL OF NEUROSCIENCE

Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice

(2012) Heather B. Madsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

(2012) Alice M Stamatakis et al.   NATURE NEUROSCIENCE

Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin

(2012) Steven J. Shabel et al.   NEURON

Lesions of the lateral habenula dissociate the reward-enhancing and locomotor-stimulant effects of amphetamine

(2012) Anthony J. Gifuni et al.   NEUROPHARMACOLOGY

Stimulation of Midbrain Dopaminergic Structures Modifies Firing Rates of Rat Lateral Habenula Neurons

(2012) Xuefeng Shen et al.   PLoS One

Chronic deep brain stimulation of the lateral habenula nucleus in a rat model of depression

(2011) Hongmei Meng et al.   BRAIN RESEARCH

Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area

(2011) Manuel Mameli et al.   NATURE NEUROSCIENCE

Propensity to ‘relapse’ following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei

(2011) M.H. James et al.   NEUROSCIENCE

Amphetamine differentially modifies the expression of monoaminergic and GABAergic synaptic boutons and processes in lateral habenula, dorsal and ventral hippocampal formation

(2011) Hsiang-Shu Yin et al.   NEUROTOXICOLOGY

Neurodevelopmental Disruption of Cortico-Striatal Function Caused by Degeneration of Habenula Neurons

(2011) Young-A Lee et al.   PLoS One

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

(2010) C. Winter et al.   BEHAVIOURAL BRAIN RESEARCH

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior

(2010) Alexander Friedman et al.   NEUROPHARMACOLOGY

Electrical stimulation of the lateral habenula produces an inhibitory effect on sucrose self-administration

(2010) Alexander Friedman et al.   NEUROPHARMACOLOGY

Effects of Drugs of Abuse on Putative Rostromedial Tegmental Neurons, Inhibitory Afferents to Midbrain Dopamine Cells

(2010) Salvatore Lecca et al.   NEUROPSYCHOPHARMACOLOGY

Morphological and electrophysiological characteristics of neurons within identified subnuclei of the lateral habenula in rat brain slices

(2010) T. Weiss et al.   NEUROSCIENCE

Identification of Brain Nuclei Implicated in Cocaine-Primed Reinstatement of Conditioned Place Preference: A Behaviour Dissociable from Sensitization

(2010) Robyn Mary Brown et al.   PLoS One

Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

(2010) F. Kasanetz et al.   SCIENCE

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient

(2009) Alexander Sartorius et al.   BIOLOGICAL PSYCHIATRY

Afferents to the GABAergic tail of the ventral tegmental area in the rat

(2009) Jennifer Kaufling et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc

(2009) Manuel Mameli et al.   NATURE NEUROSCIENCE

The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses

(2009) Thomas C. Jhou et al.   NEURON

Dopaminergic activation excites rat lateral habenular neurons in vivo

(2009) A.B. Kowski et al.   NEUROSCIENCE

Differential tonic influence of lateral habenula on prefrontal cortex and nucleus accumbens dopamine release

(2008) Lucas Lecourtier et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

(2008) Kelly L. Conrad et al.   NATURE

Representation of negative motivational value in the primate lateral habenula

(2008) Masayuki Matsumoto et al.   NATURE NEUROSCIENCE

The runway model of drug self-administration

(2008) Aaron Ettenberg   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain

(2008) I. H Bianco et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus

(2007) Li-Min Yang et al.   BEHAVIOURAL BRAIN RESEARCH