Stress transforms lateral habenula reward responses into punishment signals

Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats

(2018) Hai Zhang et al.   Brain Structure & Function

Lateral habenula in the pathophysiology of depression

(2018) Yan Yang et al.   CURRENT OPINION IN NEUROBIOLOGY

Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties

(2018) Benjamin T. Saunders et al.   NATURE NEUROSCIENCE

A neural pathway controlling motivation to exert effort

(2018) Christophe D. Proulx et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Handling method alters the hedonic value of reward in laboratory mice

(2018) Jasmine M. Clarkson et al.   Scientific Reports

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics

(2018) Alvaro Nuno-Perez et al.   Frontiers in Neuroscience

Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons

(2017) Weixin Zhong et al.   JOURNAL OF NEUROSCIENCE

Elevation of p11 in lateral habenula mediates depression-like behavior

(2017) J-S Seo et al.   MOLECULAR PSYCHIATRY

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

(2017) Anna Tchenio et al.   Nature Communications

Learning shapes the aversion and reward responses of lateral habenula neurons

(2017) Daqing Wang et al.   eLife

Serotonin7 receptors in the lateral habenular nucleus regulate depressive-like behaviors in the hemiparkinsonian rats

(2016) Ling Na Han et al.   BRAIN RESEARCH

The Lateral Habenula Circuitry: Reward Processing and Cognitive Control

(2016) Phillip M. Baker et al.   JOURNAL OF NEUROSCIENCE

A basal ganglia circuit for evaluating action outcomes

(2016) Marcus Stephenson-Jones et al.   NATURE

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

(2016) Salvatore Lecca et al.   NATURE MEDICINE

Stress and Sucrose Intake Modulate Neuronal Activity in the Anterior Hypothalamic Area in Rats

(2016) Arojit Mitra et al.   PLoS One

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia

(2015) Alexis E. Whitton et al.   CURRENT OPINION IN PSYCHIATRY

Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat

(2015) Ling-Na Han et al.   NEUROPHARMACOLOGY

Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model

(2014) Diego A. Pizzagalli   Annual Review of Clinical Psychology

Reward processing by the lateral habenula in normal and depressive behaviors

(2014) Christophe D Proulx et al.   NATURE NEUROSCIENCE

Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making

(2014) Colin M. Stopper et al.   NEURON

Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients

(2014) Xin-hua Yang et al.   PSYCHIATRY RESEARCH

A causal link between prediction errors, dopamine neurons and learning

(2013) Elizabeth E Steinberg et al.   NATURE NEUROSCIENCE

 CaMKII in Lateral Habenula Mediates Core Symptoms of Depression

(2013) K. Li et al.   SCIENCE

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

(2012) Jeremiah Y. Cohen et al.   NATURE

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

(2012) Alice M Stamatakis et al.   NATURE NEUROSCIENCE

Licking and Liking: The Assessment of Hedonic Responses in Rodents

(2012) Dominic M. Dwyer   QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Genetic Variation and Stress Interact to Influence Reward Learning

(2011) R. Bogdan et al.   JOURNAL OF NEUROSCIENCE

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

Electrical Stimulation of the Primate Lateral Habenula Suppresses Saccadic Eye Movement through a Learning Mechanism

(2011) Masayuki Matsumoto et al.   PLoS One

Reward and Punishment Processing in Depression

(2010) Neir Eshel et al.   BIOLOGICAL PSYCHIATRY

A Pallidus-Habenula-Dopamine Pathway Signals Inferred Stimulus Values

(2010) Ethan S. Bromberg-Martin et al.   JOURNAL OF NEUROPHYSIOLOGY

Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient

(2009) Alexander Sartorius et al.   BIOLOGICAL PSYCHIATRY

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

Reduced palatability in lithium- and activity-based, but not in amphetamine-based, taste aversion learning.

(2008) Dominic M. Dwyer et al.   BEHAVIORAL NEUROSCIENCE

Habenula: Crossroad between the Basal Ganglia and the Limbic System

(2008) O. Hikosaka et al.   JOURNAL OF NEUROSCIENCE

Representation of negative motivational value in the primate lateral habenula

(2008) Masayuki Matsumoto et al.   NATURE NEUROSCIENCE

The Globus Pallidus Sends Reward-Related Signals to the Lateral Habenula

(2008) Simon Hong et al.   NEURON