Circuits and functions of the lateral habenula in health and in disease

Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors

(2020) Marcus Stephenson-Jones et al.   NEURON

Glutamate Hypothesis in Schizophrenia

(2019) Yota Uno et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Lateral Habenular Burst Firing as a Target of the Rapid Antidepressant Effects of Ketamine

(2019) Yihui Cui et al.   TRENDS IN NEUROSCIENCES

A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy

(2019) Lu Huang et al.   NEURON

Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses

(2019) Massimo Trusel et al.   NEURON

Rapid, biphasic CRF neuronal responses encode positive and negative valence

(2019) Jineun Kim et al.   NATURE NEUROSCIENCE

A hypothalamus-habenula circuit controls aversion

(2019) Iakovos Lazaridis et al.   MOLECULAR PSYCHIATRY

Opposite responses to aversive stimuli in lateral habenula neurons

(2019) Mauro Congiu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Reward Inhibits Paraventricular CRH Neurons to Relieve Stress

(2019) Yuan Yuan et al.   CURRENT BIOLOGY

Habenula deep brain stimulation for refractory bipolar disorder

(2019) Chencheng Zhang et al.   Brain Stimulation

Neuronal Dynamics Regulating Brain and Behavioral State Transitions

(2019) Aaron S. Andalman et al.   CELL

Taming the “Black Dog” by Light: A Retina-Habenula Circuit Mechanism Unveiled

(2019) Yiyan Dong et al.   NEURON

NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms

(2019) Melissa A. Snyder et al.   SCHIZOPHRENIA RESEARCH

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

(2019) Kristina Valentinova et al.   NATURE NEUROSCIENCE

Stress transforms lateral habenula reward responses into punishment signals

(2019) Steven J. Shabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A neural circuit for comorbid depressive symptoms in chronic pain

(2019) Wenjie Zhou et al.   NATURE NEUROSCIENCE

Median raphe controls acquisition of negative experience in the mouse

(2019) András Szőnyi et al.   SCIENCE

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

(2019) Ignas Cerniauskas et al.   NEURON

The rostromedial tegmental nucleus modulates the development of stress-induced helpless behavior

(2018) G.I. Elmer et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

(2018) Jessica Tooley et al.   BIOLOGICAL PSYCHIATRY

Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior

(2018) Madhurima Benekareddy et al.   BIOLOGICAL PSYCHIATRY

Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats

(2018) Hai Zhang et al.   Brain Structure & Function

Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation

(2018) Cigdem Gelegen et al.   CURRENT BIOLOGY

Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq

(2018) Shristi Pandey et al.   CURRENT BIOLOGY

Lateral habenula in the pathophysiology of depression

(2018) Yan Yang et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuropeptidomics of the Rat Habenular Nuclei

(2018) Ning Yang et al.   JOURNAL OF PROTEOME RESEARCH

Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol-withdrawn rats

(2018) Seungwoo Kang et al.   NEUROPHARMACOLOGY

A neural pathway controlling motivation to exert effort

(2018) Christophe D. Proulx et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Information processing in the vertebrate habenula

(2018) Stephanie Fore et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum

(2018) Lauren Faget et al.   Nature Communications

Selective Brain Distribution and Distinctive Synaptic Architecture of Dual Glutamatergic-GABAergic Neurons

(2018) David H. Root et al.   Cell Reports

A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling

(2018) Limei Zhang et al.   Translational Psychiatry

Endocannabinoid Signaling in the Habenula Regulates Adaptive Responses to Stress

(2018) Zuxin Chen et al.   BIOLOGICAL PSYCHIATRY

Light Affects Mood and Learning through Distinct Retina-Brain Pathways

(2018) Diego Carlos Fernandez et al.   CELL

Cocaine withdrawal reduces GABAB R transmission at entopeduncular nucleus - lateral habenula synapses

(2018) Dorine Tan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway

(2018) Guang-Wei Zhang et al.   NEURON

Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics

(2018) Alvaro Nuno-Perez et al.   Frontiers in Neuroscience

Altered Volume and Functional Connectivity of the Habenula in Schizophrenia

(2017) Lei Zhang et al.   Frontiers in Human Neuroscience

Monosynaptic retrograde tracing of neurons expressing the G-protein coupled receptor Gpr151 in the mouse brain

(2017) Jonas Broms et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation

(2017) Ian McLaughlin et al.   JOURNAL OF NEUROCHEMISTRY

The Lateral Habenula and Its Input to the Rostromedial Tegmental Nucleus Mediates Outcome-Specific Conditioned Inhibition

(2017) Vincent Laurent et al.   JOURNAL OF NEUROSCIENCE

Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula

(2017) Hoyong Park et al.   JOURNAL OF NEUROSCIENCE

Elevation of p11 in lateral habenula mediates depression-like behavior

(2017) J-S Seo et al.   MOLECULAR PSYCHIATRY

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

(2017) Marisela Morales et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats

(2017) Jing Li et al.   NEUROPHARMACOLOGY

The habenula in psychiatric disorders: More than three decades of translational investigation

(2017) Marc Fakhoury   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Contributions of the lateral habenula to circadian timekeeping

(2017) Beatriz Baño-Otálora et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Electrophysiological properties of neurons and synapses in the lateral habenular complex (LHb)

(2017) Franziska Wagner et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

(2017) Daniel S. Zahm et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Circadian neurons in the lateral habenula: Clocking motivated behaviors

(2017) Jorge Mendoza   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Lateral Habenula and Adaptive Behaviors

(2017) Sheri J.Y. Mizumori et al.   TRENDS IN NEUROSCIENCES

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

(2017) Anna Tchenio et al.   Nature Communications

Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé

(2017) Youichirou Ootsuka et al.   Scientific Reports

Selectively Impaired Endocannabinoid-Dependent Long-Term Depression in the Lateral Habenula in an Animal Model of Depression

(2017) Hoyong Park et al.   Cell Reports

Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus

(2017) Li Zhou et al.   Cell Reports

Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission

(2017) David J. Barker et al.   Cell Reports

Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior

(2017) Salvatore Lecca et al.   eLife

Sleep Deprivation Influences Circadian Gene Expression in the Lateral Habenula

(2016) Beilin Zhang et al.   BEHAVIOURAL NEUROLOGY

Microarray analysis of transcripts with elevated expressions in the rat medial or lateral habenula suggest fast GABAergic excitation in the medial habenula and habenular involvement in the regulation of feeding and energy balance

(2016) Franziska Wagner et al.   Brain Structure & Function

Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences

(2016) Li Ye et al.   CELL

The habenula

(2016) Vijay Mohan K. Namboodiri et al.   CURRENT BIOLOGY

Habenula volume increases with disease severity in unmedicated major depressive disorder as revealed by 7T MRI

(2016) Frank M. Schmidt et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats

(2016) Dan Madularu et al.   HORMONES AND BEHAVIOR

Functional evidence for a direct excitatory projection from the lateral habenula to the ventral tegmental area in the rat

(2016) P. Leon Brown et al.   JOURNAL OF NEUROPHYSIOLOGY

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

(2016) A. M. Stamatakis et al.   JOURNAL OF NEUROSCIENCE

A thalamic input to the nucleus accumbens mediates opiate dependence

(2016) Yingjie Zhu et al.   NATURE

Basal forebrain projections to the lateral habenula modulate aggression reward

(2016) Sam A. Golden et al.   NATURE

A basal ganglia circuit for evaluating action outcomes

(2016) Marcus Stephenson-Jones et al.   NATURE

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

(2016) Salvatore Lecca et al.   NATURE MEDICINE

Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear

(2016) Hongbin Yang et al.   NATURE NEUROSCIENCE

Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

(2016) Frank J Meye et al.   NATURE NEUROSCIENCE

Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli

(2016) María-José Sánchez-Catalán et al.   NEUROPSYCHOPHARMACOLOGY

The relationship between negative symptom subdomains and cognition

(2016) J. Lim et al.   PSYCHOLOGICAL MEDICINE

Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?

(2016) Limei Zhang et al.   Frontiers in Neural Circuits

mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output

(2016) Kristina Valentinova et al.   Cell Reports

Mu Opioid Receptor Actions in the Lateral Habenula

(2016) Elyssa B. Margolis et al.   PLoS One

Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms

(2016) Wanhong Zuo et al.   Scientific Reports

Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons

(2015) Wanhong Zuo et al.   ADDICTION BIOLOGY

Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus

(2015) Huan Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ketamine and phencyclidine: the good, the bad and the unexpected

(2015) D Lodge et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat

(2015) Leora Yetnikoff et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal

(2015) J. Kaufling et al.   JOURNAL OF NEUROSCIENCE

From circuits to behaviour in the amygdala

(2015) Patricia H. Janak et al.   NATURE

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

(2015) Frank J Meye et al.   NATURE NEUROSCIENCE

Monoamine neurotransmitter disorders—clinical advances and future perspectives

(2015) Joanne Ng et al.   Nature Reviews Neurology

Considerations When Using Cre-Driver Rodent Lines for Studying Ventral Tegmental Area Circuitry

(2015) Garret D. Stuber et al.   NEURON

Roles of the Lateral Habenula and Anterior Cingulate Cortex in Negative Outcome Monitoring and Behavioral Adjustment in Nonhuman Primates

(2015) Takashi Kawai et al.   NEURON

Habenula Lesions Reveal that Multiple Mechanisms Underlie Dopamine Prediction Errors

(2015) Ju Tian et al.   NEURON

Diversity of Transgenic Mouse Models for Selective Targeting of Midbrain Dopamine Neurons

(2015) Stephan Lammel et al.   NEURON

Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat

(2015) Ling-Na Han et al.   NEUROPHARMACOLOGY

Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory

(2015) Victor Mathis et al.   NEUROPSYCHOPHARMACOLOGY

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

(2015) David H. Root et al.   PROGRESS IN NEUROBIOLOGY

Increased Excitability of Lateral Habenula Neurons in Adolescent Rats following Cocaine Self-Administration

(2015) P. A. Neumann et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies

(2014) Wei Hu et al.   Annals of the New York Academy of Sciences

Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5–B9) to the forebrain and brainstem

(2014) Aude Muzerelle et al.   Brain Structure & Function

Transcriptomic-anatomic analysis of the mouse habenula uncovers a high molecular heterogeneity among neurons in the lateral complex, while gene expression in the medial complex largely obeys subnuclear boundaries

(2014) Franziska Wagner et al.   Brain Structure & Function

The role of the habenula in drug addiction

(2014) Kenia M. Velasquez et al.   Frontiers in Human Neuroscience

Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior

(2014) Martine M. Mirrione et al.   Frontiers in Human Neuroscience

The medial habenula: still neglected

(2014) Humsini Viswanath et al.   Frontiers in Human Neuroscience

Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates

(2014) Jonas Broms et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Efferent Pathways of the Mouse Lateral Habenula

(2014) Lely A. Quina et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Correlating habenular subnuclei in rat and mouse by using topographic, morphological, and cytochemical criteria

(2014) Franziska Wagner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance

(2014) Wanpeng Cui et al.   JOURNAL OF NEUROSCIENCE

Role of Glutamatergic Projections from Ventral Tegmental Area to Lateral Habenula in Aversive Conditioning

(2014) D. H. Root et al.   JOURNAL OF NEUROSCIENCE

Intrinsic and extrinsic cues regulate the daily profile of mouse lateral habenula neuronal activity

(2014) Kanwal Sakhi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Single rodent mesohabenular axons release glutamate and GABA

(2014) David H Root et al.   NATURE NEUROSCIENCE

Reward processing by the lateral habenula in normal and depressive behaviors

(2014) Christophe D Proulx et al.   NATURE NEUROSCIENCE

The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger

(2014) Ryunosuke Amo et al.   NEURON

Expression of mu opioid receptor in dorsal diencephalic conduction system: New insights for the medial habenula

(2014) O. Gardon et al.   NEUROSCIENCE

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

(2014) S. J. Shabel et al.   SCIENCE

Mapping of the internal structure of human habenula with ex vivo MRI at 7T

(2013) Barbara Strotmann et al.   Frontiers in Human Neuroscience

Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat

(2013) Chemutai Sego et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Synchronous Activity of Lateral Habenular Neurons Is Essential for Regulating Hippocampal Theta Oscillation

(2013) H. Aizawa et al.   JOURNAL OF NEUROSCIENCE

Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways

(2013) T. C. Jhou et al.   JOURNAL OF NEUROSCIENCE

What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases

(2013) Colin M Stopper et al.   NATURE NEUROSCIENCE

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Neurodegeneration of lateral habenula efferent fibers after intermittent cocaine administration: Implications for deep brain stimulation

(2013) Elad Lax et al.   NEUROPHARMACOLOGY

Interactions between the Lateral Habenula and the Hippocampus: Implication for Spatial Memory Processes

(2013) Romain Goutagny et al.   NEUROPSYCHOPHARMACOLOGY

Role of the lateral habenula in shaping context-dependent locomotor activity during cognitive tasks

(2013) Zhengda Wang et al.   NEUROREPORT

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

(2013) T. Takeuchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

T-Type Ca2+ Channels in Normal and Abnormal Brain Functions

(2013) Eunji Cheong et al.   PHYSIOLOGICAL REVIEWS

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

(2013) J. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 CaMKII in Lateral Habenula Mediates Core Symptoms of Depression

(2013) K. Li et al.   SCIENCE

DREADDing the lateral habenula: A review of methodological approaches for studying lateral habenula function

(2012) Sunila G. Nair et al.   BRAIN RESEARCH

Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat

(2012) Uhnoh Kim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular characterization of the subnuclei in rat habenula

(2012) Hidenori Aizawa et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mapping pain activation and connectivity of the human habenula

(2012) L. Shelton et al.   JOURNAL OF NEUROPHYSIOLOGY

Serotonin Selectively Modulates Reward Value in Human Decision-Making

(2012) B. Seymour et al.   JOURNAL OF NEUROSCIENCE

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

(2012) Alice M Stamatakis et al.   NATURE NEUROSCIENCE

Encoding asymmetry within neural circuits

(2012) Miguel L. Concha et al.   NATURE REVIEWS NEUROSCIENCE

Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin

(2012) Steven J. Shabel et al.   NEURON

Unmasking the mysteries of the habenula in pain and analgesia

(2012) L. Shelton et al.   PROGRESS IN NEUROBIOLOGY

Differential projections from the lateral habenula to the rostromedial tegmental nucleus and ventral tegmental area in the rat

(2011) Luciano Gonçalves et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling

(2011) Christian Lüscher et al.   NEURON

Habenular Signaling in Nicotine Reinforcement

(2011) Christie D Fowler et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitory Inputs from Rostromedial Tegmental Neurons Regulate Spontaneous Activity of Midbrain Dopamine Cells and Their Responses to Drugs of Abuse

(2011) Salvatore Lecca et al.   NEUROPSYCHOPHARMACOLOGY

The inhibitory influence of the lateral habenula on midbrain dopamine cells: Ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus

(2010) Judith Joyce Balcita-Pedicino et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cloning, Characterization, and Distribution of a μ-Opioid Receptor in Rat Brain

(2010) Roman L. Zastawny et al.   JOURNAL OF NEUROCHEMISTRY

Coding of Task Reward Value in the Dorsal Raphe Nucleus

(2010) E. S. Bromberg-Martin et al.   JOURNAL OF NEUROSCIENCE

Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula

(2010) R. Amo et al.   JOURNAL OF NEUROSCIENCE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain

(2010) K. Brinschwitz et al.   NEUROSCIENCE

Circadian oscillators in the epithalamus

(2010) C. Guilding et al.   NEUROSCIENCE

Morphological and electrophysiological characteristics of neurons within identified subnuclei of the lateral habenula in rat brain slices

(2010) T. Weiss et al.   NEUROSCIENCE

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient

(2009) Alexander Sartorius et al.   BIOLOGICAL PSYCHIATRY

Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area

(2009) Natalia Omelchenko et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The mesopontine rostromedial tegmental nucleus and the emotional motor system: Role in basic survival behavior

(2009) Gert Holstege   JOURNAL OF COMPARATIVE NEUROLOGY

Afferents to the GABAergic tail of the ventral tegmental area in the rat

(2009) Jennifer Kaufling et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta

(2009) Thomas C. Jhou et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cerebral Activity during the Anesthesia-Like State Induced by Mesopontine Microinjection of Pentobarbital

(2009) R. Abulafia et al.   JOURNAL OF NEUROSCIENCE

Medullary Circuitry Regulating Rapid Eye Movement Sleep and Motor Atonia

(2009) R. Vetrivelan et al.   JOURNAL OF NEUROSCIENCE

Midbrain Dopamine Neurons Signal Preference for Advance Information about Upcoming Rewards

(2009) Ethan S. Bromberg-Martin et al.   NEURON

The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses

(2009) Thomas C. Jhou et al.   NEURON

Dopaminergic activation excites rat lateral habenular neurons in vivo

(2009) A.B. Kowski et al.   NEUROSCIENCE

Neurochemical phenotypes of the afferent and efferent projections of the mouse medial habenula

(2009) C. Qin et al.   NEUROSCIENCE

Nicotinic receptors in the habenula: importance for memory

(2009) D. Sanders et al.   NEUROSCIENCE

Differential projections from subfields in the lateral preoptic area to the lateral habenular complex of the rat

(2008) Alexander B. Kowski et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Role of endogenous sleep-wake and analgesic systems in anesthesia

(2008) Jun Lu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Habenula: Crossroad between the Basal Ganglia and the Limbic System

(2008) O. Hikosaka et al.   JOURNAL OF NEUROSCIENCE

Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Representation of negative motivational value in the primate lateral habenula

(2008) Masayuki Matsumoto et al.   NATURE NEUROSCIENCE

The Globus Pallidus Sends Reward-Related Signals to the Lateral Habenula

(2008) Simon Hong et al.   NEURON

The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain

(2008) I. H Bianco et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

An emerging link between general anesthesia and sleep

(2008) R. Allada   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addiction and the Brain Antireward System

(2007) George F. Koob et al.   Annual Review of Psychology

Electrolytic lesions of the habenula attenuate brain stimulation reward

(2007) Marie-Claude Morissette et al.   BEHAVIOURAL BRAIN RESEARCH