CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy

Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages

(2021) Martina Di Nunzio et al.   EPILEPSIA

Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

(2020) Paola Maffi et al.   DIABETES CARE

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?

(2020) Wolfgang Löscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors

(2020) Takahisa Hanada   Biomolecules

Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus

(2020) Nicholas H. Varvel et al.   JOURNAL OF NEUROSCIENCE

Peripheral blood gene expression signatures associated with epilepsy and its etiologic classification

(2019) Chitra Rawat et al.   GENOMICS

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis

(2019) Xiu-xiu Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cannabis Influences the Putative Cytokines-Related Pathway of Epilepsy among Egyptian Epileptic Patients

(2019) Yasmeen M. Taalab et al.   Brain Sciences

CXCL1 activates TRPV1 via Gi/o protein and actin filaments

(2018) Alexandru Florian Deftu et al.   LIFE SCIENCES

Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells

(2018) Federica Frigerio et al.   MOLECULAR NEUROBIOLOGY

Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

(2018) E. A. van Vliet et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy

(2018) Theodor Rüber et al.   BRAIN

Microglial phenotypes in the human epileptic temporal lobe

(2018) Mélanie Morin-Brureau et al.   BRAIN

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence

(2018) Andrea Arena et al.   BRAIN PATHOLOGY

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study

(2018) Luca Bartolini et al.   Frontiers in Neurology

Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury

(2017) William B. Gallentine et al.   EPILEPSIA

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

(2017) Gaetano Terrone et al.   EPILEPSIA

Chemokines as new inflammatory players in the pathogenesis of epilepsy

(2017) Chiara Cerri et al.   EPILEPSY RESEARCH

Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus

(2017) Dai-Shi Tian et al.   JOURNAL OF NEUROSCIENCE

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

CXCR1/2 pathways in paclitaxel-induced neuropathic pain

(2017) Brandolini Laura et al.   Oncotarget

A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4+ or CD8+ T Cells Using Immunodeficient NOG Mice

(2016) R. Ito et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Febrile infection-related epilepsy syndrome treated with anakinra

(2016) Daniel L. Kenney-Jung et al.   ANNALS OF NEUROLOGY

Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

(2016) Jacqueline A. Hubbard et al.   EXPERIMENTAL NEUROLOGY

Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy

(2016) Kenneth I. Strauss et al.   Journal of Neuroinflammation

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Laura Pasetto et al.   JOURNAL OF NEUROSCIENCE

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation

(2016) Chiara Cerri et al.   JOURNAL OF NEUROSCIENCE

Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy

(2016) Rosaria Pascente et al.   NEUROBIOLOGY OF DISEASE

Inflammatory mediators in human epilepsy: A systematic review and meta-analysis

(2016) Evelien E. de Vries et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats

(2016) Li-hua Yang et al.   NEUROSCIENCE LETTERS

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pilot study on reparixin, a CXCR1/2 antagonist, to assess safety and efficacy in attenuating ischaemia-reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery

(2015) P. Opfermann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling

(2015) Laura Brandolini et al.   Oncotarget

Role of Astrocytes in Epilepsy

(2015) D. A. Coulter et al.   Cold Spring Harbor Perspectives in Medicine

Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2

(2014) De-Li Cao et al.   EXPERIMENTAL NEUROLOGY

Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus

(2014) Hiroshi Sakuma et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods

(2013) Ingmar Blümcke et al.   EPILEPSIA

Fractalkine/CX3CL1 modulates GABAAcurrents in human temporal lobe epilepsy

(2013) Cristina Roseti et al.   EPILEPSIA

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue

(2013) Katharina Pernhorst et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

The TARC/sICAM5 Ratio in Patient Plasma is a Candidate Biomarker for Drug Resistant Epilepsy

(2013) John R. Pollard et al.   Frontiers in Neurology

Elevated Interleukin-8 Enhances Prefrontal Synaptic Transmission in Mice with Persistent Inflammatory Pain

(2012) Guang-Bin Cui et al.   Molecular Pain

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage

(2010) Jean-Pierre Louboutin et al.   FASEB JOURNAL

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy

(2009) Veerle De Herdt et al.   JOURNAL OF NEUROIMMUNOLOGY

Cellular injury and neuroinflammation in children with chronic intractable epilepsy

(2009) Jieun Choi et al.   Journal of Neuroinflammation

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

(2008) Genshin Mouri et al.   BRAIN RESEARCH

Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice

(2008) A Zarbock et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Chemokine CXCL1/Growth Related Oncogene Increases Sodium Currents and Neuronal Excitability in Small Diameter Sensory Neurons

(2008) Jun-Gang Wang et al.   Molecular Pain